{"id":"https://openalex.org/W51540510","doi":"https://doi.org/10.1042/bj2660545","title":"19F-n.m.r. studies of ligand binding to 5-fluorotryptophan- and 3-fluorotyrosine-containing cyclic AMP receptor protein from Escherichia coli","display_name":"19F-n.m.r. studies of ligand binding to 5-fluorotryptophan- and 3-fluorotyrosine-containing cyclic AMP receptor protein from Escherichia coli","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W51540510","doi":"https://doi.org/10.1042/bj2660545","mag":"51540510","pmid":"https://pubmed.ncbi.nlm.nih.gov/2156500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131166"},"language":"en","primary_location":{"id":"doi:10.1042/bj2660545","doi":"https://doi.org/10.1042/bj2660545","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2660545","pdf_url":"https://portlandpress.com/biochemj/article-pdf/266/2/545/598470/bj2660545.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/266/2/545/598470/bj2660545.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041473423","display_name":"F Sixl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F Sixl","raw_affiliation_strings":["Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111600190","display_name":"Rodney William King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R W King","raw_affiliation_strings":["Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043803143","display_name":"Matthew L. Bracken","orcid":"https://orcid.org/0000-0003-2336-1469","observed_orcids":["https://orcid.org/0000-0003-2336-1469"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Bracken","raw_affiliation_strings":["Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113512320","display_name":"James Feeney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Feeney","raw_affiliation_strings":["Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Biochemistry Division, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K","institution_ids":["https://openalex.org/I4405285715"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405285715"],"apc_list":null,"apc_paid":null,"fwci":3.0708,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.91425456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"266","issue":"2","first_page":"545","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.2273000031709671,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-amp-receptor-protein","display_name":"cyclic AMP receptor protein","score":0.9779999852180481},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7080000042915344},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9660000205039978},{"id":"https://openalex.org/keywords/5-fluorotryptophan","display_name":"5-fluorotryptophan","score":0.968999981880188},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.921999990940094},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tubercidin","display_name":"tubercidin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.6863213777542114},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.6674602031707764},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.664569616317749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6205174326896667},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6003087162971497},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5951231122016907},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5240119695663452},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46642762422561646},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.4482899308204651},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.43876123428344727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33874762058258057},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3215307593345642},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0868421196937561},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011953","descriptor_name":"Receptors, Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj2660545","doi":"https://doi.org/10.1042/bj2660545","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2660545","pdf_url":"https://portlandpress.com/biochemj/article-pdf/266/2/545/598470/bj2660545.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4425355","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131166","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1131166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1131166","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2156500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2156500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2660545","doi":"https://doi.org/10.1042/bj2660545","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2660545","pdf_url":"https://portlandpress.com/biochemj/article-pdf/266/2/545/598470/bj2660545.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W51540510.pdf","grobid_xml":"https://content.openalex.org/works/W51540510.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W191474238","https://openalex.org/W1522960621","https://openalex.org/W1594497161","https://openalex.org/W1675260448","https://openalex.org/W1974579873","https://openalex.org/W1979027602","https://openalex.org/W1981262848","https://openalex.org/W1985339961","https://openalex.org/W1989051169","https://openalex.org/W1997689415","https://openalex.org/W1999219397","https://openalex.org/W2005476334","https://openalex.org/W2021563901","https://openalex.org/W2026362296","https://openalex.org/W2027087381","https://openalex.org/W2038530511","https://openalex.org/W2039567118","https://openalex.org/W2055611111","https://openalex.org/W2057646733","https://openalex.org/W2065149562","https://openalex.org/W2066637826","https://openalex.org/W2084038555","https://openalex.org/W2093876265","https://openalex.org/W2108519118","https://openalex.org/W2139972801","https://openalex.org/W2156439743","https://openalex.org/W2165748041","https://openalex.org/W4234219166"],"related_works":["https://openalex.org/W2271189536","https://openalex.org/W2025877455","https://openalex.org/W2016433378","https://openalex.org/W2002701440","https://openalex.org/W2014284437","https://openalex.org/W2087985351","https://openalex.org/W2146184449","https://openalex.org/W1585951595","https://openalex.org/W1973082118","https://openalex.org/W4242154252"],"abstract_inverted_index":{"Two":[0],"fluorine-containing":[1],"analogues":[2,73],"of":[3,18,27,41,66,70,81,89,94,96,105,133,158,164,167,205,209,240,253,275,291,317,326],"the":[4,28,35,42,51,67,71,75,79,86,97,113,156,165,178,185,198,203,210,232,238,249,267,276,287,292,315,321,327,332,335,340,343,349],"cyclic":[5,82,136,146,159,186,219,268,318],"AMP":[6,83,187,220,234],"receptor":[7],"protein":[8,294],"(CRP)":[9],"from":[10,126,142],"Escherichia":[11],"coli":[12],"were":[13,285],"prepared":[14],"by":[15,145,155,197,314],"biosynthetic":[16],"incorporation":[17],"5-fluorotryptophan":[19],"(5-F-Trp)":[20],"and":[21,39,77,93,217,280,309,334],"3-fluorotyrosine":[22],"(3-F-Tyr).":[23],"The":[24,130,161,324],"19F-n.m.r.":[25,68,131,162,223,282,328],"spectrum":[26,163,224],"[5-F-Trp]CRP":[29],"showed":[30,44,138,176],"two":[31,36,95],"signals":[32,46],"corresponding":[33,49],"to":[34,50,307,311,320],"tryptophan":[37,91],"residues,":[38,279],"that":[40,85,149,190,225,230,237,262,339],"[3-F-Tyr]CRP":[43,168,201,254],"six":[45,52,98,277],"(two":[47],"overlapping)":[48],"tyrosine":[53,99,250,278],"residues:":[54],"these":[55,106,121],"results":[56],"are":[57,153],"as":[58,182,289,346],"expected":[59],"for":[60,184,231,296],"a":[61,258,264],"symmetrical":[62],"dimer.":[63],"A":[64],"comparison":[65],"spectra":[69,132],"CRP":[72,337],"in":[74,78,109,202,331,348],"presence":[76,204],"absence":[80],"reveals":[84],"chemical":[87,283,329],"shifts":[88,284,330],"both":[90],"residues":[92,100,107],"show":[101],"differences.":[102],"Since":[103],"none":[104],"is":[108,118,263],"direct":[110],"contact":[111],"with":[112,135,169,229,255],"bound":[114],"nucleotide":[115,199,319],"(although":[116],"Trp-85":[117],"fairly":[119],"close),":[120],"shift":[122],"changes":[123,152,181,193,247],"must":[124],"arise":[125],"induced":[127,154,196],"conformational":[128,151,192,246],"effects.":[129],"complexes":[134],"GMP":[137],"chemical-shift":[139,180],"perturbations":[140],"different":[141,150],"those":[143,290],"caused":[144],"AMP,":[147],"indicating":[148,189,236],"binding":[157,239,316],"GMP.":[160],"complex":[166],"tubercidin":[170],"3',5'-(cyclic)monophosphate":[171],"(which":[172],"can":[173],"activate":[174],"transcription)":[175],"essentially":[177,286],"same":[179,288,344],"seen":[183],"complex,":[188,235],"similar":[191],"have":[194],"been":[195],"binding.":[200],"an":[206,222],"equimolar":[207],"amount":[208],"20":[211],"bp":[212],"self-complementary":[213],"DNA":[214,241],"oligomer":[215],"5'-AATGTGAGTTAACTCACATT-3'":[216],"excess":[218],"gave":[221],"was":[226],"almost":[227],"identical":[228],"[3-F-Tyr]CRP-cyclic":[233],"does":[242],"not":[243],"induce":[244],"significant":[245],"involving":[248],"residues.":[251],"Proteolysis":[252],"chymotrypsin":[256],"produced":[257],"31":[259],"kDa":[260],"fragment":[261,272],"dimer":[265],"containing":[266],"AMP-binding":[269],"domain.":[270],"This":[271],"contains":[273],"five":[274],"its":[281],"intact":[293,322,336,350],"except":[295],"one":[297],"missing":[298],"signal":[299,303],"(signal":[300],"F):":[301],"this":[302],"could":[304],"be":[305,312],"assigned":[306],"Tyr-206":[308],"shown":[310],"unperturbed":[313],"[3-F-Tyr]CRP.":[323],"similarity":[325],"alpha-fragment":[333,341],"indicates":[338],"retains":[342],"structure":[345],"found":[347],"protein.(ABSTRACT":[351],"TRUNCATED":[352],"AT":[353],"400":[354],"WORDS)":[355]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
