{"id":"https://openalex.org/W51522959","doi":null,"title":"Splicing and Multiple Binding Proteins in the Corticotropin-Releasing Hormone Stress System.","display_name":"Splicing and Multiple Binding Proteins in the Corticotropin-Releasing Hormone Stress System.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W51522959","mag":"51522959"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.9027","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.9027","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/86399/evansrt_1.pdf%3Bjsessionid%3D3CE1E0254A437A90506153398F997313?sequence%3D1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ryan Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ryan Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00696203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.24060000479221344,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":1.0},{"id":"https://openalex.org/keywords/crh-receptor-2","display_name":"CRH receptor 2","score":0.753000020980835},{"id":"https://openalex.org/keywords/crh-receptor-1","display_name":"CRH receptor 1","score":0.7710000276565552},{"id":"https://openalex.org/keywords/crh-binding-protein","display_name":"CRH-binding protein","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7789999842643738},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ligand-binding-kinetics","display_name":"ligand binding kinetics","score":0.7910000085830688},{"id":"https://openalex.org/keywords/nonsense-mediated-mrna-decay","display_name":"nonsense-mediated mRNA decay","score":0.7760000228881836},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.7319999933242798},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/receptor-inhibition","display_name":"receptor inhibition","score":0.4180000126361847},{"id":"https://openalex.org/keywords/stress-biology","display_name":"stress biology","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6166589856147766},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6018860936164856},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5910028219223022},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.5400726199150085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5279868245124817},{"id":"https://openalex.org/C2779179475","wikidata":"https://www.wikidata.org/wiki/Q3545649","display_name":"Decoy","level":3,"score":0.5214487910270691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5158583521842957},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.47674477100372314},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4536442756652832},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.43279439210891724},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.4187619090080261},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.4109548032283783},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3236497640609741},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31487640738487244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28037673234939575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24242925643920898},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.20915022492408752}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.9027","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.9027","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/86399/evansrt_1.pdf%3Bjsessionid%3D3CE1E0254A437A90506153398F997313?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/86399","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/86399/1/evansrt_1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:51522959","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/86399","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":263,"referenced_works":["https://openalex.org/W61407429","https://openalex.org/W152612465","https://openalex.org/W1486788208","https://openalex.org/W1495277562","https://openalex.org/W1505918285","https://openalex.org/W1522975530","https://openalex.org/W1524192703","https://openalex.org/W1531005638","https://openalex.org/W1540969441","https://openalex.org/W1558625773","https://openalex.org/W1572525448","https://openalex.org/W1578920705","https://openalex.org/W1594183867","https://openalex.org/W1594254388","https://openalex.org/W1659705459","https://openalex.org/W1661124518","https://openalex.org/W1662654526","https://openalex.org/W1763193602","https://openalex.org/W1848229294","https://openalex.org/W1933900219","https://openalex.org/W1951492130","https://openalex.org/W1960866690","https://openalex.org/W1964889875","https://openalex.org/W1966507830","https://openalex.org/W1966681494","https://openalex.org/W1966904260","https://openalex.org/W1967133523","https://openalex.org/W1968807977","https://openalex.org/W1971598401","https://openalex.org/W1972956730","https://openalex.org/W1973787362","https://openalex.org/W1973873048","https://openalex.org/W1975029917","https://openalex.org/W1975190412","https://openalex.org/W1975498688","https://openalex.org/W1977827530","https://openalex.org/W1977900030","https://openalex.org/W1978000199","https://openalex.org/W1979516391","https://openalex.org/W1981690975","https://openalex.org/W1984325789","https://openalex.org/W1985186821","https://openalex.org/W1985278711","https://openalex.org/W1985362971","https://openalex.org/W1985821149","https://openalex.org/W1986061203","https://openalex.org/W1986576876","https://openalex.org/W1986882197","https://openalex.org/W1986981233","https://openalex.org/W1987852700","https://openalex.org/W1988520394","https://openalex.org/W1988664153","https://openalex.org/W1989918919","https://openalex.org/W1991161616","https://openalex.org/W1991192480","https://openalex.org/W1991224812","https://openalex.org/W1992074719","https://openalex.org/W1993003470","https://openalex.org/W1993176825","https://openalex.org/W1993288925","https://openalex.org/W1993512624","https://openalex.org/W1993539031","https://openalex.org/W1993855849","https://openalex.org/W1994134409","https://openalex.org/W1994615343","https://openalex.org/W1996252484","https://openalex.org/W1997603202","https://openalex.org/W1999536713","https://openalex.org/W2001443391","https://openalex.org/W2002428435","https://openalex.org/W2002456558","https://openalex.org/W2003973797","https://openalex.org/W2003991729","https://openalex.org/W2004469232","https://openalex.org/W2004716084","https://openalex.org/W2004954728","https://openalex.org/W2005285770","https://openalex.org/W2005325329","https://openalex.org/W2005731408","https://openalex.org/W2007539214","https://openalex.org/W2007896659","https://openalex.org/W2008311225","https://openalex.org/W2009388623","https://openalex.org/W2009516385","https://openalex.org/W2011232802","https://openalex.org/W2012416101","https://openalex.org/W2013160020","https://openalex.org/W2013639852","https://openalex.org/W2014457539","https://openalex.org/W2015529328","https://openalex.org/W2016693654","https://openalex.org/W2017124573","https://openalex.org/W2017168736","https://openalex.org/W2018282412","https://openalex.org/W2018841004","https://openalex.org/W2019409747","https://openalex.org/W2019500639","https://openalex.org/W2019723988","https://openalex.org/W2021336190","https://openalex.org/W2022138356","https://openalex.org/W2022626941","https://openalex.org/W2022679721","https://openalex.org/W2022912683","https://openalex.org/W2023118502","https://openalex.org/W2023344951","https://openalex.org/W2023506303","https://openalex.org/W2023507956","https://openalex.org/W2024802935","https://openalex.org/W2025585440","https://openalex.org/W2026530461","https://openalex.org/W2027669774","https://openalex.org/W2028710649","https://openalex.org/W2028997551","https://openalex.org/W2030900991","https://openalex.org/W2032725109","https://openalex.org/W2033932995","https://openalex.org/W2034321834","https://openalex.org/W2034767261","https://openalex.org/W2036523102","https://openalex.org/W2037593319","https://openalex.org/W2039201808","https://openalex.org/W2039370934","https://openalex.org/W2041787174","https://openalex.org/W2041845056","https://openalex.org/W2043409393","https://openalex.org/W2043701428","https://openalex.org/W2043889971","https://openalex.org/W2043915483","https://openalex.org/W2044331640","https://openalex.org/W2046013541","https://openalex.org/W2046225097","https://openalex.org/W2046906266","https://openalex.org/W2047002583","https://openalex.org/W2048845625","https://openalex.org/W2048976709","https://openalex.org/W2049376754","https://openalex.org/W2051618430","https://openalex.org/W2051931991","https://openalex.org/W2052444839","https://openalex.org/W2052930863","https://openalex.org/W2052973557","https://openalex.org/W2053166015","https://openalex.org/W2055926767","https://openalex.org/W2056502129","https://openalex.org/W2058348206","https://openalex.org/W2059474567","https://openalex.org/W2059523990","https://openalex.org/W2060135457","https://openalex.org/W2060431393","https://openalex.org/W2061025691","https://openalex.org/W2062175922","https://openalex.org/W2063371064","https://openalex.org/W2063684521","https://openalex.org/W2067603887","https://openalex.org/W2068818952","https://openalex.org/W2069187419","https://openalex.org/W2070065061","https://openalex.org/W2071767667","https://openalex.org/W2071783417","https://openalex.org/W2071903454","https://openalex.org/W2072590456","https://openalex.org/W2073282022","https://openalex.org/W2074005421","https://openalex.org/W2074198695","https://openalex.org/W2074446107","https://openalex.org/W2076243093","https://openalex.org/W2076569615","https://openalex.org/W2077376040","https://openalex.org/W2078240329","https://openalex.org/W2078573448","https://openalex.org/W2079190456","https://openalex.org/W2079560131","https://openalex.org/W2080764093","https://openalex.org/W2081196613","https://openalex.org/W2081264545","https://openalex.org/W2081501475","https://openalex.org/W2081705863","https://openalex.org/W2082146795","https://openalex.org/W2083006633","https://openalex.org/W2083836198","https://openalex.org/W2089601285","https://openalex.org/W2089762123","https://openalex.org/W2090557381","https://openalex.org/W2090779643","https://openalex.org/W2091036574","https://openalex.org/W2091654745","https://openalex.org/W2091784278","https://openalex.org/W2092829453","https://openalex.org/W2093466882","https://openalex.org/W2093677355","https://openalex.org/W2094481749","https://openalex.org/W2095646540","https://openalex.org/W2095870212","https://openalex.org/W2096809080","https://openalex.org/W2096898812","https://openalex.org/W2098517630","https://openalex.org/W2102204014","https://openalex.org/W2103018436","https://openalex.org/W2103897951","https://openalex.org/W2104200952","https://openalex.org/W2104244040","https://openalex.org/W2105402655","https://openalex.org/W2107337535","https://openalex.org/W2108244474","https://openalex.org/W2108743747","https://openalex.org/W2110748165","https://openalex.org/W2112699297","https://openalex.org/W2114794569","https://openalex.org/W2115078524","https://openalex.org/W2115236606","https://openalex.org/W2116191377","https://openalex.org/W2116900183","https://openalex.org/W2118238128","https://openalex.org/W2119766596","https://openalex.org/W2120835858","https://openalex.org/W2121472302","https://openalex.org/W2127552596","https://openalex.org/W2128635872","https://openalex.org/W2130167598","https://openalex.org/W2130189270","https://openalex.org/W2131044939","https://openalex.org/W2132782816","https://openalex.org/W2132856391","https://openalex.org/W2133386615","https://openalex.org/W2134818464","https://openalex.org/W2136942244","https://openalex.org/W2137239773","https://openalex.org/W2141926683","https://openalex.org/W2143629083","https://openalex.org/W2144369724","https://openalex.org/W2144464892","https://openalex.org/W2145696892","https://openalex.org/W2146283474","https://openalex.org/W2147846603","https://openalex.org/W2148165244","https://openalex.org/W2148984531","https://openalex.org/W2149670166","https://openalex.org/W2150639208","https://openalex.org/W2152713646","https://openalex.org/W2152885509","https://openalex.org/W2154597715","https://openalex.org/W2157398451","https://openalex.org/W2158871620","https://openalex.org/W2160830028","https://openalex.org/W2161216221","https://openalex.org/W2161746138","https://openalex.org/W2161901724","https://openalex.org/W2162181411","https://openalex.org/W2164624484","https://openalex.org/W2166983778","https://openalex.org/W2170174733","https://openalex.org/W2171243908","https://openalex.org/W2171574059","https://openalex.org/W2171846995","https://openalex.org/W2186821170","https://openalex.org/W2279162254","https://openalex.org/W2281502357","https://openalex.org/W2301920008","https://openalex.org/W2401047377","https://openalex.org/W2419069634","https://openalex.org/W2951457310","https://openalex.org/W2952450708","https://openalex.org/W3021509188"],"related_works":["https://openalex.org/W2007896659","https://openalex.org/W2609552445","https://openalex.org/W2296366259","https://openalex.org/W2079122766","https://openalex.org/W3153878485","https://openalex.org/W7097993601","https://openalex.org/W2083836198","https://openalex.org/W2390328414","https://openalex.org/W2188614733","https://openalex.org/W2046906266"],"abstract_inverted_index":{"Corticotropin-releasing":[0],"hormone":[1],"(CRH)":[2],"is":[3,29,202,268],"an":[4,47,167,269],"important":[5,48],"mediator":[6],"of":[7,56,67,80,91,108,140,183,213,229,289,297,310,319,328,344],"the":[8,52,59,65,72,83,104,114,137,157,176,180,227,285,290,295,305,308,317,326,330,337],"mammalian":[9],"stress":[10,348],"response.":[11],"Functioning":[12],"both":[13,76,329],"as":[14,98,206],"a":[15,38,149,207],"neurotransmitter":[16],"and":[17,26,54,82,125,171,195,220,232,252,259,287,312,332,340],"endocrine":[18],"hormone,":[19],"it":[20],"signals":[21],"through":[22],"two":[23],"receptors,":[24,60,306],"CRH-R1":[25],"CRH-R2.":[27],"CRH":[28,73,249,256,338],"also":[30],"bound":[31],"with":[32,185,250,300],"high-affinity":[33],"by":[34,175],"CRH-Binding":[35],"Protein":[36],"(CRH-BP),":[37],"secreted":[39],"glycoprotein.":[40],"As":[41],"soluble":[42,121,208],"binding":[43,69,334],"proteins":[44,70,129,335],"can":[45],"play":[46],"role":[49,327],"in":[50,71,145,281,315,336,347],"modulating":[51],"availability":[53],"activity":[55],"ligands":[57],"at":[58],"this":[61,238],"thesis":[62],"focuses":[63],"on":[64,294],"characterization":[66],"multiple":[68],"system,":[74],"including":[75],"truncated":[77],"splice":[78,89,118],"forms":[79],"CRH-R2":[81,92,109,122,279],"classical":[84],"CRH-BP.":[85,320],"First,":[86],"we":[87,274],"identified":[88],"variants":[90],"that":[93,136,218,255,276],"were":[94,240],"predicted":[95,150],"to":[96,113,166,204,237,303],"serve":[97],"soluble-decoy":[99],"receptors":[100],"because":[101],"they":[102],"encode":[103,127],"extracellular,":[105],"ligand-binding":[106],"domain":[107],"but":[110,130],"terminate":[111],"prior":[112,302],"transmembrane":[115],"domains.":[116],"These":[117],"variants,":[119],"called":[120],"(sCRH-R2)":[123],"\u03b1":[124,138],"\u03b2,":[126],"similar":[128],"have":[131],"unique":[132,187],"N-termini.":[133],"We":[134,243],"demonstrated":[135,275],"isoform":[139,182],"sCRH-R2":[141],"was":[142,160,172,190,292],"efficiently":[143],"translated":[144],"vivo,":[146],"despite":[147],"being":[148],"substrate":[151],"for":[152,163,193,223,248,263],"nonsense-mediated":[153],"RNA":[154],"decay;":[155],"however,":[156],"resulting":[158],"protein":[159],"not":[161,241],"trafficked":[162,192],"secretion":[164,194],"due":[165],"ineffective":[168],"signal":[169,188],"peptide,":[170,189],"consequently":[173],"degraded":[174],"proteasome.":[177],"In":[178],"contrast,":[179],"\u03b2":[181],"sCRH-R2,":[184],"its":[186],"properly":[191],"escaped":[196],"degradation.":[197],"Therefore,":[198],"unlike":[199],"sCRH-R2\u03b1,":[200],"sCRH-R2\u03b2":[201],"positioned":[203],"function":[205,318,346],"CRH-binding":[209],"protein.":[210],"For":[211],"analysis":[212],"CRH-BP,":[214,264],"current":[215],"models":[216],"suggest":[217],"CRH-BP":[219,251,267,277,301],"CRH-receptors":[221],"compete":[222],"available":[224],"ligand,":[225],"yet":[226],"rate":[228],"ligand":[230,271,298],"association":[231],"dissociation,":[233],"which":[234,265],"are":[235],"paramount":[236],"competition,":[239],"established.":[242],"determined":[244],"these":[245,322],"kinetic":[246,311],"parameters":[247],"CRH-R2,":[253],"showing":[254],"binds":[257],"faster":[258],"releases":[260],"more":[261],"slowly":[262],"suggests":[266],"efficient":[270],"trap.":[272],"Furthermore,":[273],"inhibits":[278],"activation":[280],"cell":[282],"culture.":[283],"Strikingly,":[284],"amplitude":[286],"duration":[288],"inhibition":[291],"dependent":[293],"time":[296],"interaction":[299],"encountering":[304],"highlighting":[307],"importance":[309],"temporal":[313],"considerations":[314],"defining":[316],"Together,":[321],"studies":[323],"further":[324],"characterize":[325],"classic":[331],"alternative":[333],"system":[339],"advance":[341],"our":[342],"understanding":[343],"their":[345],"biology.":[349]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}