{"id":"https://openalex.org/W51439519","doi":"https://doi.org/10.1007/978-1-59259-239-5_14","title":"Promoting Articular Cartilage Repair","display_name":"Promoting Articular Cartilage Repair","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W51439519","doi":"https://doi.org/10.1007/978-1-59259-239-5_14","mag":"51439519"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-239-5_14","doi":"https://doi.org/10.1007/978-1-59259-239-5_14","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-239-5_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Therapeutics in Rheumatic Diseases","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4406347238","display_name":"Modern Therapeutics in Rheumatic Diseases"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-1-59259-239-5_14","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064323409","display_name":"Joseph A. Buckwalter","orcid":"https://orcid.org/0000-0003-4308-7583","observed_orcids":["https://orcid.org/0000-0003-4308-7583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Buckwalter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015592017","display_name":"James A. Martin","orcid":"https://orcid.org/0000-0001-5085-0108","observed_orcids":["https://orcid.org/0000-0001-5085-0108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A. Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7666,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79069767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"201","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-cartilage-repair","display_name":"articular cartilage repair","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.9269999861717224},{"id":"https://openalex.org/keywords/osteochondral-lesions","display_name":"osteochondral defects","score":0.8700000047683716},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/articular-cartilage-degeneration","display_name":"articular cartilage degeneration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5529999732971191},{"id":"https://openalex.org/keywords/perichondrium","display_name":"perichondrium","score":0.8019999861717224},{"id":"https://openalex.org/keywords/periosteum","display_name":"periosteum","score":0.925000011920929},{"id":"https://openalex.org/keywords/chondrocyte-transplantation","display_name":"chondrocyte transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.8460000157356262},{"id":"https://openalex.org/keywords/joint-distraction","display_name":"joint distraction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/osteotomy","display_name":"osteotomy","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6513699889183044},{"id":"https://openalex.org/C25515809","wikidata":"https://www.wikidata.org/wiki/Q663949","display_name":"Perichondrium","level":3,"score":0.6442010402679443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5566754341125488},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5119031667709351},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5070807933807373},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.49419596791267395},{"id":"https://openalex.org/C2777564180","wikidata":"https://www.wikidata.org/wiki/Q3109230","display_name":"Articular cartilage repair","level":5,"score":0.4874275028705597},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.4702630937099457},{"id":"https://openalex.org/C3017587775","wikidata":"https://www.wikidata.org/wiki/Q9644","display_name":"Articular surface","level":2,"score":0.42026031017303467},{"id":"https://openalex.org/C2779663596","wikidata":"https://www.wikidata.org/wiki/Q2741512","display_name":"Synovial joint","level":5,"score":0.4164014458656311},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38257747888565063},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.37947067618370056},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3460890054702759},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3290789723396301},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2590632140636444},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2052055299282074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15060856938362122},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-59259-239-5_14","doi":"https://doi.org/10.1007/978-1-59259-239-5_14","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-239-5_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Therapeutics in Rheumatic Diseases","raw_type":"book-chapter"},{"id":"mag:51439519","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-239-5_14.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/978-1-59259-239-5_14","doi":"https://doi.org/10.1007/978-1-59259-239-5_14","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-239-5_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Therapeutics in Rheumatic Diseases","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W10734947","https://openalex.org/W155490374","https://openalex.org/W185095087","https://openalex.org/W658115929","https://openalex.org/W1522229466","https://openalex.org/W1535380624","https://openalex.org/W1712241578","https://openalex.org/W1751474090","https://openalex.org/W1825470077","https://openalex.org/W1899567144","https://openalex.org/W1943677324","https://openalex.org/W1969196646","https://openalex.org/W1969760903","https://openalex.org/W1978035620","https://openalex.org/W1978478023","https://openalex.org/W1979639779","https://openalex.org/W1984155551","https://openalex.org/W1988592246","https://openalex.org/W1988873510","https://openalex.org/W1992074071","https://openalex.org/W1999092107","https://openalex.org/W1999449667","https://openalex.org/W2003388024","https://openalex.org/W2006078662","https://openalex.org/W2006566021","https://openalex.org/W2007211438","https://openalex.org/W2010723436","https://openalex.org/W2012619102","https://openalex.org/W2013534129","https://openalex.org/W2016363042","https://openalex.org/W2018169305","https://openalex.org/W2019176288","https://openalex.org/W2023815284","https://openalex.org/W2026664906","https://openalex.org/W2027549197","https://openalex.org/W2032168208","https://openalex.org/W2036553623","https://openalex.org/W2037997875","https://openalex.org/W2051589104","https://openalex.org/W2058514588","https://openalex.org/W2058719729","https://openalex.org/W2061438378","https://openalex.org/W2061491319","https://openalex.org/W2065497694","https://openalex.org/W2078006107","https://openalex.org/W2082955838","https://openalex.org/W2082977231","https://openalex.org/W2083482485","https://openalex.org/W2085110580","https://openalex.org/W2100562749","https://openalex.org/W2100973934","https://openalex.org/W2103765130","https://openalex.org/W2104327876","https://openalex.org/W2104635917","https://openalex.org/W2106128380","https://openalex.org/W2107478870","https://openalex.org/W2112735634","https://openalex.org/W2119436088","https://openalex.org/W2128844449","https://openalex.org/W2137320484","https://openalex.org/W2139048422","https://openalex.org/W2139771120","https://openalex.org/W2140607870","https://openalex.org/W2160730596","https://openalex.org/W2160768625","https://openalex.org/W2164870722","https://openalex.org/W2175515551","https://openalex.org/W2228774988","https://openalex.org/W2269741659","https://openalex.org/W2281256922","https://openalex.org/W2291873350","https://openalex.org/W2323505059","https://openalex.org/W2332526426","https://openalex.org/W2336728522","https://openalex.org/W2346124523","https://openalex.org/W2399721782","https://openalex.org/W2411094306","https://openalex.org/W2417010238","https://openalex.org/W2418454501","https://openalex.org/W2426350210","https://openalex.org/W2469475898","https://openalex.org/W2769251443","https://openalex.org/W4233136586","https://openalex.org/W4240067091","https://openalex.org/W4244069863","https://openalex.org/W4245067015","https://openalex.org/W4245616144","https://openalex.org/W4285719527","https://openalex.org/W4299574698","https://openalex.org/W4318599416","https://openalex.org/W4323874393"],"related_works":["https://openalex.org/W2103765130","https://openalex.org/W2043893714","https://openalex.org/W40933133","https://openalex.org/W2143224845","https://openalex.org/W2779602449","https://openalex.org/W124350502","https://openalex.org/W2468344214","https://openalex.org/W7171525859","https://openalex.org/W2506587804","https://openalex.org/W1985392836"],"abstract_inverted_index":{"For":[0],"more":[1],"than":[2],"250":[3,71],"years,":[4,72],"physicians":[5],"and":[6,45,80,95,98,120,126,131,168,171,208,216,234],"scientists":[7],"have":[8,84,222],"been":[9],"seeking":[10],"ways":[11],"to":[12,27,52,158,218,226,235],"repair":[13,136],"or":[14,22],"regenerate":[15],"synovial-joint":[16,109],"articular":[17,31,48,59,124,183],"surfaces":[18,184,197],"following":[19],"articular-cartilage":[20],"loss":[21],"degeneration":[23],"(1\u20133).":[24],"(Repair":[25],"refers":[26,51],"restoring":[28,231],"a":[29],"damaged":[30],"surface":[32],"with":[33],"new":[34,54,182],"tissue":[35,55,107],"that":[36,86,117,132,143,175],"resembles":[37],"but":[38,73],"does":[39],"not":[40],"duplicate":[41],"the":[42,67,75,135,141,203,211],"structure,":[43],"composition,":[44],"function":[46,233],"of":[47,69,88,105,140,146,153,165,181,188,195,205,214],"cartilage;":[49],"regeneration":[50],"forming":[53],"indistinguishable":[56],"from":[57],"normal":[58],"cartilage":[60,125],"[4\u20136].)":[61],"They":[62],"made":[63,223],"little":[64],"progress":[65],"for":[66,192],"majority":[68],"these":[70,176,189],"in":[74,108,138,230],"last":[76],"three":[77],"decades":[78],"clinical":[79,241],"basic":[81],"scientific":[82],"investigations":[83],"shown":[85,174],"implantation":[87],"artificial":[89],"matrices,":[90],"growth":[91],"factors,":[92],"perichondrium,":[93],"periosteum":[94],"transplanted":[96],"chondrocytes,":[97],"mesenchymal":[99],"stem":[100],"cells":[101],"can":[102,122,178],"stimulate":[103,179],"formation":[104,180,194],"cartilaginous":[106],"osteochondral":[110],"defects":[111],"(6\u201310).":[112],"Other":[113],"work":[114],"has":[115,173,198],"demonstrated":[116],"joint":[118,127,169,232],"loading":[119],"motion":[121],"influence":[123],"healing":[128],"(11\u201313)":[129],",":[130],"mechanical-loading":[133],"influences":[134],"process":[137],"all":[139],"tissues":[142],"form":[144],"parts":[145],"synovial":[147],"joints":[148],"(5,14,15).":[149],"In":[150],"addition,":[151],"review":[152],"several":[154],"operative":[155],"procedures":[156,177],"used":[157],"treat":[159],"osteoarthrosis":[160],"(OA),":[161],"including":[162],"osteotomies,":[163],"penetration":[164],"subchondral":[166],"bone,":[167],"distraction":[170],"motion,":[172],"(9).The":[185],"apparent":[186],"potential":[187],"multiple":[190],"methods":[191,215],"stimulating":[193],"cartilaginous-articular":[196],"created":[199],"great":[200],"interest":[201],"on":[202],"part":[204],"patients,":[206],"physicians,":[207],"scientists,":[209],"however":[210],"wide":[212],"variety":[213],"approaches":[217],"assessing":[219],"their":[220,228,237],"results":[221],"it":[224],"difficult":[225],"evaluate":[227],"success":[229],"define":[236],"most":[238],"appropriate":[239],"current":[240],"applications.":[242]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
