{"id":"https://openalex.org/W51373122","doi":null,"title":"Defensive behavior and hypertension induced by glutamate in the midbrain central gray of the rat.","display_name":"Defensive behavior and hypertension induced by glutamate in the midbrain central gray of the rat.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W51373122","mag":"51373122","pmid":"https://pubmed.ncbi.nlm.nih.gov/4063549"},"language":"en","primary_location":{"id":"pmid:4063549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4063549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088604083","display_name":"Jos\u00e9 Eduardo Krieger","orcid":"https://orcid.org/0000-0001-5464-1792","observed_orcids":["https://orcid.org/0000-0001-5464-1792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Krieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086794252","display_name":"Frederico Guilherme Graeff","orcid":"https://orcid.org/0000-0002-0746-3118","observed_orcids":["https://orcid.org/0000-0002-0746-3118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F G Graeff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3988,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.87960906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"61","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.25999999046325684,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.25999999046325684,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.24950000643730164,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/defensive-behavior","display_name":"defensive behavior","score":0.8799999952316284},{"id":"https://openalex.org/keywords/glutamate-microinjection","display_name":"glutamate microinjection","score":0.7379999756813049},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9049999713897705},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.675000011920929},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7459999918937683},{"id":"https://openalex.org/keywords/freezing-behavior","display_name":"freezing behavior","score":0.9010000228881836},{"id":"https://openalex.org/keywords/flight-behavior","display_name":"flight behavior","score":0.8880000114440918},{"id":"https://openalex.org/keywords/autonomic-responses","display_name":"autonomic responses","score":0.550000011920929},{"id":"https://openalex.org/keywords/midbrain-tegmentum","display_name":"midbrain tegmentum","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.8703269958496094},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.8374077677726746},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.8235132694244385},{"id":"https://openalex.org/C2909233451","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjections","level":3,"score":0.6075021624565125},{"id":"https://openalex.org/C2778074680","wikidata":"https://www.wikidata.org/wiki/Q2125439","display_name":"Cannula","level":2,"score":0.5889599919319153},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5652731657028198},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.5208178758621216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5084940195083618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47112321853637695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46878373622894287},{"id":"https://openalex.org/C24566897","wikidata":"https://www.wikidata.org/wiki/Q943621","display_name":"Tegmentum","level":4,"score":0.4387856721878052},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4105070233345032},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38334324955940247},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3566770553588867},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3253522515296936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3218957483768463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30034762620925903},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07882943749427795},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004924","descriptor_name":"Escape Reaction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4063549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4063549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas","raw_type":"Journal Article"},{"id":"mag:51373122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4063549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088582596","https://openalex.org/W2003991837","https://openalex.org/W2043557913","https://openalex.org/W2020627198","https://openalex.org/W2047195123","https://openalex.org/W2092455062","https://openalex.org/W2024533531","https://openalex.org/W2133319067","https://openalex.org/W2092058060","https://openalex.org/W2009233599"],"abstract_inverted_index":{"In":[0,42,86],"order":[1],"to":[2],"localize":[3],"groups":[4],"of":[5,12,29,64,119,176,210,216,224],"neurons":[6,217],"commanding":[7],"the":[8,26,65,83,98,114,150,155,170,174,177,183,207,211,225],"defense":[9,148,226],"reaction,":[10],"microinjections":[11],"L-glutamate":[13],"(GLU,":[14],"5":[15],"nmol":[16],"in":[17,60,113,140,143,161,169],"0.2":[18],"microliter,":[19],"during":[20],"20":[21],"s)":[22],"were":[23,153,167],"made":[24],"inside":[25,154,182],"dorsal":[27,156,208],"midbrain":[28,171],"unanesthetized":[30],"rats":[31,142],"provided":[32],"with":[33],"an":[34],"intra-arterial":[35],"cannula":[36],"for":[37],"blood":[38],"pressure":[39],"(BP)":[40],"recording.":[41],"9":[43,87],"rats,":[44,89],"GLU":[45,66,90,145,163,189],"microinjection":[46,91],"induced":[47,146],"freezing":[48],"behavior":[49,96],"or":[50,181],"flight,":[51],"accompanied":[52],"by":[53,132],"a":[54,147,214],"30.1":[55],"+/-":[56,70,77,103],"4.8":[57],"mmHg":[58],"increase":[59,100],"BP.":[61],"The":[62],"latency":[63],"effect":[67],"was":[68,101,165],"16":[69],"2":[71],"s":[72],"and":[73,97,129,194,221],"its":[74],"duration":[75],"89":[76],"8":[78],"s,":[79],"as":[80],"measured":[81],"from":[82],"BP":[84,99,131],"recordings.":[85],"other":[88],"did":[92,124],"not":[93,125,199],"evoke":[94],"defensive":[95],"6.0":[102],"0.9":[104],"mmHg,":[105],"significantly":[106],"lower":[107],"(P":[108],"less":[109,133],"than":[110,112,134],"0.001)":[111],"former":[115],"group.":[116],"Control":[117],"injections":[118],"artificial":[120],"cerebrospinal":[121],"fluid":[122],"(CSF)":[123],"cause":[126],"behavioral":[127,220],"changes":[128],"increased":[130],"3":[135],"mmHg.":[136],"Histology":[137],"revealed":[138],"that":[139,206,218],"all":[141],"which":[144,162],"reaction":[149],"injection":[151,164],"sites":[152],"periaqueductal":[157],"gray":[158],"(PAG).":[159],"Sites":[160],"ineffective":[166],"localized":[168],"tegmentum,":[172],"outside":[173],"borders":[175],"PAG":[178,185,209],"(8":[179],"rats),":[180],"ventral":[184],"(1":[186],"rat).":[187],"Since":[188],"stimulates":[190],"neuron":[191],"cell":[192],"bodies":[193],"their":[195],"dendritic":[196],"processes":[197],"but":[198],"passing":[200],"axons,":[201],"these":[202],"results":[203],"strongly":[204],"suggest":[205],"rat":[212],"contains":[213],"group":[215],"controls":[219],"autonomic":[222],"manifestations":[223],"reaction.":[227]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
