{"id":"https://openalex.org/W51359046","doi":null,"title":"Lower airways remodeling in nonasthmatic subjects with allergic rhinitis.","display_name":"Lower airways remodeling in nonasthmatic subjects with allergic rhinitis.","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W51359046","mag":"51359046","pmid":"https://pubmed.ncbi.nlm.nih.gov/8941218"},"language":"en","primary_location":{"id":"pmid:8941218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8941218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000657922","display_name":"Jamila Chakir","orcid":"https://orcid.org/0000-0002-6628-8743","observed_orcids":["https://orcid.org/0000-0002-6628-8743"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Chakir","raw_affiliation_strings":["Unit\u00e9 de Recherche, Centre de Pneumologie de l'H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche, Centre de Pneumologie de l'H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084946954","display_name":"Michel Laviolette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Laviolette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108459096","display_name":"Michel Boutet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Boutet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Lalibert\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Lalibert\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Dub\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Dub\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110330139","display_name":"LP Boulet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L P Boulet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6616,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.89454569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"5","first_page":"735","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/subepithelial-fibrosis","display_name":"subepithelial fibrosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7919999957084656},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":1.0},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.875},{"id":"https://openalex.org/keywords/bronchial-mucosa","display_name":"bronchial mucosa","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8252849578857422},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.8074710369110107},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.7732038497924805},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.6109527349472046},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5661869645118713},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.557417631149292},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5376698970794678},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.505406379699707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49522557854652405},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4836381673812866},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.46572014689445496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46206697821617126},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3742409348487854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3153248727321625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06771916151046753}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8941218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8941218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Comparative Study"},{"id":"mag:51359046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8941218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2095796890","https://openalex.org/W2061853352","https://openalex.org/W2090154737","https://openalex.org/W2081034984","https://openalex.org/W6908099770","https://openalex.org/W2002432755","https://openalex.org/W2019164546","https://openalex.org/W2117691369","https://openalex.org/W7164349025","https://openalex.org/W2515278576"],"abstract_inverted_index":{"We":[0],"analyzed":[1],"by":[2,202],"immunohistochemistry":[3],"the":[4,20,77,99,125,148,165,177,190,208,216],"distribution":[5],"of":[6,24,57,135,156,162,192,210,219],"types":[7],"I,":[8],"II,":[9,137],"III,":[10],"IV,":[11,138],"V,":[12,139],"and":[13,17,34,49,60,112,115,120,140,143,153,195,198],"VII":[14,141],"collagens,":[15],"laminin,":[16],"fibronectin":[18,89,105,116],"in":[19,41,65,76,91,96,131,147,167,170,183,215,226,231],"bronchial":[21,157,203],"biopsy":[22],"specimens":[23],"nonasthmatic":[25],"subjects":[26,67,83,184,222],"with":[27,38,69,84,185],"seasonal":[28],"allergic":[29,44,85,186,220],"rhinitis":[30,86,168,187],"(n":[31,46,52],"=":[32,47,53],"8)":[33],"compared":[35,68],"these":[36],"results":[37,188,206],"those":[39],"found":[40],"mild":[42],"stable":[43],"asthmatics":[45],"6)":[48],"normal":[50],"controls":[51],"5).":[54],"The":[55],"content":[56],"type":[58,110,136,193],"I":[59,111,194],"III":[61,113,196],"collagens":[62,72,114,142,197],"was":[63],"increased":[64],"rhinitic":[66,132,221],"controls.":[70],"These":[71,173,205],"were":[73,117,130,145],"focally":[74],"deposited":[75],"reticular":[78],"basement":[79,93,126],"membrane":[80,127],"area.":[81],"Three":[82],"had":[87,102],"no":[88],"deposition":[90,191],"their":[92],"membrane,":[94],"as":[95,169],"controls,":[97],"whereas":[98],"other":[100],"five":[101],"a":[103,160],"focal":[104],"deposition.":[106],"In":[107],"asthmatic":[108],"patients,":[109],"more":[118,121],"abundant":[119],"uniformly":[122],"distributed":[123,179],"underneath":[124],"than":[128],"they":[129],"subjects.":[133,172],"Expression":[134],"laminin":[144],"similar":[146,225],"three":[149],"groups.":[150],"Electron":[151],"microscopic":[152],"immunohistochemical":[154],"analyses":[155],"mucosa":[158],"showed":[159],"network":[161],"myofibroblasts":[163],"beneath":[164],"epithelium":[166],"asthma":[171],"data":[174],"show":[175],"that":[176,223,229],"irregularly":[178],"subepithelial":[180],"fibrosis":[181],"observed":[182],"from":[189],"fibronectin,":[199],"probably":[200],"produced":[201],"myofibroblasts.":[204],"suggest":[207],"presence":[209],"an":[211],"active":[212],"structural":[213],"remodeling":[214],"lower":[217],"airways":[218],"is":[224],"nature":[227],"to":[228],"seen":[230],"asthma,":[232],"although":[233],"less":[234],"marked.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}