{"id":"https://openalex.org/W51261484","doi":null,"title":"The Interaction of Targeted and Non-Targeted Nanoparticles with Cells and Model Membranes.","display_name":"The Interaction of Targeted and Non-Targeted Nanoparticles with Cells and Model Membranes.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W51261484","mag":"51261484"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/58463","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/58463","pdf_url":"https://hdl.handle.net/2027.42/58463","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/58463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041932148","display_name":"Pascale R. Leroueil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pascale R. Leroueil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041932148"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.8980000019073486},{"id":"https://openalex.org/keywords/folate-binding-protein","display_name":"folate binding protein","score":0.6520000100135803},{"id":"https://openalex.org/keywords/multivalent-binding","display_name":"multivalent binding","score":0.6330000162124634},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nanoparticle-cell-interactions","display_name":"nanoparticle-cell interactions","score":0.5389999747276306},{"id":"https://openalex.org/keywords/polycationic-polymers","display_name":"polycationic polymers","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pore-formation","display_name":"pore formation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/supported-lipid-bilayers","display_name":"supported lipid bilayers","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dimyristoylphosphatidylcholine","display_name":"dimyristoylphosphatidylcholine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nanoparticle-cytotoxicity","display_name":"nanoparticle cytotoxicity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/surface-area-effect","display_name":"surface area effect","score":0.39100000262260437},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.4490000009536743},{"id":"https://openalex.org/keywords/silica-nanoparticles","display_name":"silica nanoparticles","score":0.4099999964237213},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5816653966903687},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5258491635322571},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44610515236854553},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34790897369384766},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.32392019033432007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29533153772354126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08392545580863953}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/58463","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/58463","pdf_url":"https://hdl.handle.net/2027.42/58463","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:51261484","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/58463","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/58463","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/58463","pdf_url":"https://hdl.handle.net/2027.42/58463","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W51261484.pdf","grobid_xml":"https://content.openalex.org/works/W51261484.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W1087259","https://openalex.org/W1175056953","https://openalex.org/W1485490516","https://openalex.org/W1489018618","https://openalex.org/W1512898834","https://openalex.org/W1535728477","https://openalex.org/W1555450157","https://openalex.org/W1565425041","https://openalex.org/W1601577933","https://openalex.org/W1647609745","https://openalex.org/W1863914224","https://openalex.org/W1928718614","https://openalex.org/W1965800158","https://openalex.org/W1966875882","https://openalex.org/W1969497292","https://openalex.org/W1973710057","https://openalex.org/W1974745277","https://openalex.org/W1978653530","https://openalex.org/W1979110040","https://openalex.org/W1979839814","https://openalex.org/W1980285981","https://openalex.org/W1980323956","https://openalex.org/W1980395831","https://openalex.org/W1980441330","https://openalex.org/W1981152200","https://openalex.org/W1981705717","https://openalex.org/W1981792803","https://openalex.org/W1982117697","https://openalex.org/W1992095148","https://openalex.org/W1992627415","https://openalex.org/W1994628935","https://openalex.org/W1995980440","https://openalex.org/W1996545689","https://openalex.org/W1999449340","https://openalex.org/W2001263656","https://openalex.org/W2001582257","https://openalex.org/W2002338306","https://openalex.org/W2004533106","https://openalex.org/W2006622749","https://openalex.org/W2007651537","https://openalex.org/W2010655741","https://openalex.org/W2013086386","https://openalex.org/W2013470095","https://openalex.org/W2016085763","https://openalex.org/W2017003131","https://openalex.org/W2019526697","https://openalex.org/W2019877102","https://openalex.org/W2022856181","https://openalex.org/W2028440527","https://openalex.org/W2029532796","https://openalex.org/W2030855909","https://openalex.org/W2034210172","https://openalex.org/W2034416799","https://openalex.org/W2036995103","https://openalex.org/W2037048276","https://openalex.org/W2037452464","https://openalex.org/W2037789918","https://openalex.org/W2038040669","https://openalex.org/W2039208932","https://openalex.org/W2040170408","https://openalex.org/W2041072987","https://openalex.org/W2042493999","https://openalex.org/W2043521465","https://openalex.org/W2047037071","https://openalex.org/W2047176776","https://openalex.org/W2048680502","https://openalex.org/W2049133733","https://openalex.org/W2050085273","https://openalex.org/W2051643294","https://openalex.org/W2052603036","https://openalex.org/W2056286679","https://openalex.org/W2058784226","https://openalex.org/W2059160261","https://openalex.org/W2063668324","https://openalex.org/W2064169997","https://openalex.org/W2065946609","https://openalex.org/W2068067779","https://openalex.org/W2068416744","https://openalex.org/W2069631908","https://openalex.org/W2072229818","https://openalex.org/W2077530741","https://openalex.org/W2080005848","https://openalex.org/W2080031538","https://openalex.org/W2080343780","https://openalex.org/W2080726302","https://openalex.org/W2080923544","https://openalex.org/W2081100721","https://openalex.org/W2083437069","https://openalex.org/W2086069830","https://openalex.org/W2087193499","https://openalex.org/W2092045871","https://openalex.org/W2092492380","https://openalex.org/W2093050875","https://openalex.org/W2095248480","https://openalex.org/W2096406493","https://openalex.org/W2096442705","https://openalex.org/W2097007428","https://openalex.org/W2097535374","https://openalex.org/W2100600921","https://openalex.org/W2101621191","https://openalex.org/W2105678378","https://openalex.org/W2107205997","https://openalex.org/W2107807737","https://openalex.org/W2110111661","https://openalex.org/W2110621232","https://openalex.org/W2112632406","https://openalex.org/W2114340483","https://openalex.org/W2115378502","https://openalex.org/W2117326659","https://openalex.org/W2117998009","https://openalex.org/W2120710734","https://openalex.org/W2122872625","https://openalex.org/W2124898246","https://openalex.org/W2125044103","https://openalex.org/W2126630077","https://openalex.org/W2129732513","https://openalex.org/W2130513806","https://openalex.org/W2133215388","https://openalex.org/W2138129903","https://openalex.org/W2142177142","https://openalex.org/W2145921425","https://openalex.org/W2146707480","https://openalex.org/W2148726864","https://openalex.org/W2150953709","https://openalex.org/W2151642983","https://openalex.org/W2153262958","https://openalex.org/W2154033456","https://openalex.org/W2155118487","https://openalex.org/W2157489799","https://openalex.org/W2162001660","https://openalex.org/W2163010987","https://openalex.org/W2163294691","https://openalex.org/W2163701045","https://openalex.org/W2165418613","https://openalex.org/W2167812052","https://openalex.org/W2169781816","https://openalex.org/W2170543410","https://openalex.org/W2481759204","https://openalex.org/W3022515699","https://openalex.org/W3148913165","https://openalex.org/W4313309889"],"related_works":["https://openalex.org/W4298340650","https://openalex.org/W3157250442","https://openalex.org/W1986876300","https://openalex.org/W2413565536","https://openalex.org/W2898749317","https://openalex.org/W2805779861","https://openalex.org/W2911551229","https://openalex.org/W1968945227","https://openalex.org/W1966313604","https://openalex.org/W2096406493"],"abstract_inverted_index":{"The":[0,165,276,301],"first":[1],"component":[2,167],"of":[3,9,68,84,116,138,141,162,168,174,177,269,283,313,328],"the":[4,7,32,65,69,82,98,103,106,136,139,155,172,298,306,314,318],"thesis":[5,170],"examines":[6,171],"binding":[8,78],"a":[10,40,61,72,109,114,146,159,175,259,281],"multivalent,":[11],"folic":[12],"acid":[13],"(FA)":[14],"receptor":[15,75],"targeted,":[16],"generation":[17],"5":[18],"(G5)":[19],"PAMAM":[20,192,290],"dendrimer":[21],"using":[22,297],"force":[23,99,130,233],"pulling":[24,91],"spectroscopy.":[25],"This":[26,256],"targeted":[27],"nanoparticle,":[28],"when":[29],"conjugated":[30],"to":[31,38,46,96,101,135,153,158,204,322,344],"therapeutic":[33],"methotrexate":[34],"and":[35,108,124,183,190,199,215,242,280,292,336],"then":[36,94],"acetylated":[37],"form":[39],"neutral":[41,238],"complex,":[42],"has":[43],"been":[44],"shown":[45,203,343],"be":[47],"effective":[48],"at":[49],"reducing":[50],"FA-receptor":[51],"expressing":[52],"KB":[53],"cell":[54],"tumors.":[55],"Surface":[56],"plasmon":[57],"resonance":[58],"(SPR)":[59],"showed":[60],"100,000-fold":[62],"decrease":[63],"in":[64,128,209,222,251,348],"dissociation":[66],"rate":[67],"G5-FAn":[70,111,117,144],"from":[71,88,113,305],"model":[73,184],"FA":[74],"surface,":[76],"folate":[77],"protein":[79],"(FBP),":[80],"as":[81,211,219,221,229],"number":[83,140,161],"FAs":[85,142],"(n)":[86],"increased":[87],"1-12.":[89],"Force":[90],"spectroscopy":[92],"was":[93,131,150],"used":[95],"compare":[97],"required":[100],"rupture":[102,129],"interaction":[104,173,277],"between":[105,278],"FBP":[107],"single":[110],"taken":[112,304],"solution":[115],"where":[118],"n":[119],"=":[120],"0,":[121],"4.7,":[122],"2.7,":[123],"7.2.":[125],"A":[126],"difference":[127],"measured":[132,156,212,230],"but":[133],"due":[134],"heterogeneity":[137],"per":[143],"within":[145],"given":[147],"solution,":[148],"it":[149],"not":[151,246],"possible":[152,260],"assign":[154],"forces":[157],"specific":[160],"FA-FBP":[163],"interactions.":[164],"second":[166],"this":[169],"variety":[176,282],"non-targeted,":[178],"charged":[179,285,329],"nanoparticles":[180,286,316],"with":[181],"cells":[182,210,252,270],"membranes.":[185],"Five":[186],"polycationic":[187,263,315],"polymers":[188,239],"(G5":[189],"G7":[191],"dendrimer,":[193],"branched":[194],"polyethylenimine":[195],"(PEI),":[196],"poly-L-lysine":[197],"(PLL)":[198],"diethylaminoethyl-dextran":[200],"(DEAE-DEX))":[201],"were":[202,294,341],"induce":[205,247,345],"nanoscale":[206,248,273],"hole":[207,249,274,346],"formation":[208,250,347],"by":[213,231],"enzyme":[214],"dye":[216],"diffusion":[217],"assays,":[218],"well":[220],"dimyristoylphosphatidylcholine":[223],"(DMPC)":[224],"supported":[225],"lipid":[226],"bilayers":[227],"(SLB)":[228],"atomic":[232],"microscopy":[234],"(AFM).":[235],"In":[236,325],"contrast,":[237],"polyethylene":[240],"glycol":[241],"polyvinyl":[243],"alcohol":[244],"did":[245],"or":[253],"DMPC":[254],"SLBs.":[255,349],"suggests":[257],"that":[258,310],"mechanism":[261],"for":[262],"polymer":[264],"internalization":[265],"and/or":[266],"nanoparticle-induced":[267],"cytotoxicity":[268],"is":[271,309,317],"through":[272],"formation.":[275],"SLBs":[279],"other":[284],"(MSI-78,":[287],"Au-NH2,":[288],"G3-NH2":[289],"dendron,":[291],"silica-NH2":[293],"also":[295,342],"investigated":[296],"AFM-SLB":[299,307],"assay.":[300],"general":[302],"trend":[303],"studies":[308],"surface":[311],"area":[312],"largest":[319],"contributing":[320],"factor":[321],"membrane":[323],"disruption.":[324],"addition,":[326],"micelles":[327],"detergents":[330],"cetyl":[331],"trimethylammonium":[332],"bromide":[333,334],"(CTAB)":[335],"sodium":[337],"dodecyl":[338],"sulfate":[339],"(SDS)":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}