{"id":"https://openalex.org/W51224289","doi":null,"title":"Plasma thrombopoietin levels in patients with aplastic anemia and idiopathic thrombocytopenic purpura.","display_name":"Plasma thrombopoietin levels in patients with aplastic anemia and idiopathic thrombocytopenic purpura.","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W51224289","mag":"51224289","pmid":"https://pubmed.ncbi.nlm.nih.gov/12150725"},"language":"en","primary_location":{"id":"pmid:12150725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12150725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100524973","display_name":"Jing Gu","orcid":"https://orcid.org/0000-0002-0744-5964","observed_orcids":["https://orcid.org/0000-0002-0744-5964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Gu","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Nantong Medical College, Nantong Medical College, Nantong 226001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Nantong Medical College, Nantong Medical College, Nantong 226001, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lu Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077764073","display_name":"Ruirong Xu","orcid":"https://orcid.org/0000-0002-9871-1542","observed_orcids":["https://orcid.org/0000-0002-9871-1542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruirong Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101710169","display_name":"Xiufang Chen","orcid":"https://orcid.org/0000-0002-8795-6923","observed_orcids":["https://orcid.org/0000-0002-8795-6923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiufang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.0046188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"115","issue":"7","first_page":"983","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":1.0},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8100000023841858},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.9621243476867676},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.7577898502349854},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7486109733581543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7412381768226624},{"id":"https://openalex.org/C2779771385","wikidata":"https://www.wikidata.org/wiki/Q6132707","display_name":"Thrombocytopenic purpura","level":3,"score":0.7008811831474304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.644683301448822},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6056469082832336},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3936142325401306},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36517277359962463},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32534259557724},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.11675170063972473},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.08088016510009766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12150725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12150725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2998057928","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/10020440344","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:51224289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12150725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W59348996","https://openalex.org/W4399486413","https://openalex.org/W2079807050","https://openalex.org/W1982526924","https://openalex.org/W2033248764","https://openalex.org/W3024007481","https://openalex.org/W2032966235","https://openalex.org/W2006004940","https://openalex.org/W2028378683","https://openalex.org/W131887615"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,9,18,51,101,170],"role":[4],"of":[5,11,22,160,172],"thrombopoietin":[6],"(TPO)":[7],"in":[8,24,33,60,68,154],"pathology":[10],"chronic":[12],"thrombocytopenic":[13,38],"disease.":[14],"METHODS:":[15],"We":[16],"measured":[17],"endogenous":[19],"plasma":[20,90,134],"concentration":[21],"TPO":[23,55,91,102,135,141,161],"40":[25],"patients":[26,35,62,97],"with":[27,36,70,98,121],"acquired":[28],"aplastic":[29],"anaemia":[30],"(AA)":[31],"and":[32,49,81,93,114,137,156,158,168],"32":[34],"idiopathic":[37],"purpura":[39],"(ITP)":[40],"by":[41,148,152],"a":[42,84],"sensitive":[43],"Sandwich":[44],"enzyme-linked":[45],"immunosorbent":[46],"assay":[47],"(ELISA)":[48],"compared":[50,120],"results.":[52],"RESULTS:":[53],"Plasma":[54],"concentrations":[56,92],"were":[57,104],"significantly":[58],"higher":[59],"AA":[61,155],"(774":[63],"+/-":[64,75,111],"393":[65],"pg/":[66],"ml)":[67],"comparison":[69],"healthy":[71,122],"control":[72],"subjects":[73],"(55":[74],"34":[76],"pg/ml,":[77],"P":[78],"<":[79],"0.001),":[80],"there":[82,115],"was":[83,116,128],"significant":[85,118],"negative":[86],"correlation":[87],"between":[88,132],"their":[89,133],"platelet":[94,138],"counts.":[95,139],"In":[96],"ITP,":[99,157],"however,":[100],"levels":[103,136,142,162],"normal":[105],"or":[106],"only":[107,147],"slightly":[108],"elevated":[109],"(73":[110],"36":[112],"pg/ml),":[113],"no":[117,130],"difference":[119],"controls":[123],"(P":[124],">":[125],"0.05).":[126],"There":[127],"also":[129,151],"relationship":[131],"CONCLUSIONS:":[140],"may":[143],"be":[144],"regulated":[145],"not":[146],"platelets":[149],"but":[150],"megakaryocytes":[153],"measurement":[159],"is":[163],"useful":[164],"for":[165],"diagnosing":[166],"thrombocytopenia":[167],"understanding":[169],"pathophysiology":[171],"thrombocytopenia.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}