{"id":"https://openalex.org/W50928386","doi":null,"title":"Ambient Light Intensity, Actigraphy, Sleep and Respiration, Circadian Temperature and Melatonin Rhythms and Daytime Performance of Crew Members During Space Flight on STS-90 and STS-95 Missions","display_name":"Ambient Light Intensity, Actigraphy, Sleep and Respiration, Circadian Temperature and Melatonin Rhythms and Daytime Performance of Crew Members During Space Flight on STS-90 and STS-95 Missions","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W50928386","mag":"50928386"},"language":"en","primary_location":{"id":"pmh:oai:casi.ntrs.nasa.gov:20000020659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2060/20000020659","pdf_url":"http://hdl.handle.net/2060/20000020659","source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1305493378","host_organization_name":"NASA Headquarters","host_organization_lineage":["https://openalex.org/I1305493378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CASI","raw_type":"Proceedings of the First Biennial Space Biomedical Investigators' Workshop; 544-546"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2060/20000020659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087686970","display_name":"Charles Andrew Czeisler","orcid":"https://orcid.org/0000-0002-7408-1849","observed_orcids":["https://orcid.org/0000-0002-7408-1849"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Czeisler","raw_affiliation_strings":["Brigham and Women'S Hospital Boston MA United States"],"raw_orcid":"https://orcid.org/0000-0002-7408-1849","affiliations":[{"raw_affiliation_string":"Brigham and Women'S Hospital Boston MA United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080896827","display_name":"Derk\u2010Jan Dijk","orcid":"https://orcid.org/0000-0001-5314-1008","observed_orcids":["https://orcid.org/0000-0001-5314-1008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derk\u2010Jan Dijk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5314-1008","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072563217","display_name":"David F. Neri","orcid":"https://orcid.org/0000-0003-1393-1181","observed_orcids":["https://orcid.org/0000-0003-1393-1181"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Neri","raw_affiliation_strings":["California Univ. San Diego, CA, United States"],"raw_orcid":"https://orcid.org/0000-0003-1393-1181","affiliations":[{"raw_affiliation_string":"California Univ. San Diego, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004161051","display_name":"Rod J. Hughes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rod J. Hughes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036155950","display_name":"Joseph M. Ronda","orcid":"https://orcid.org/0000-0003-3878-7673","observed_orcids":["https://orcid.org/0000-0003-3878-7673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph M. Ronda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3878-7673","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090817416","display_name":"James K. Wyatt","orcid":"https://orcid.org/0000-0001-6454-1736","observed_orcids":["https://orcid.org/0000-0001-6454-1736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James K. Wyatt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6454-1736","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076031696","display_name":"John B. West","orcid":"https://orcid.org/0000-0002-7123-482X","observed_orcids":["https://orcid.org/0000-0002-7123-482X"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. West","raw_affiliation_strings":["California Univ. Santa Barbara, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Univ. Santa Barbara, CA, United States","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052375468","display_name":"G. Kim Prisk","orcid":"https://orcid.org/0000-0002-6344-4720","observed_orcids":["https://orcid.org/0000-0002-6344-4720"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Kim Prisk","raw_affiliation_strings":["California Univ. San Diego, CA, United States"],"raw_orcid":"https://orcid.org/0000-0002-6344-4720","affiliations":[{"raw_affiliation_string":"California Univ. San Diego, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014605000","display_name":"Ann R. Elliott","orcid":"https://orcid.org/0000-0002-7959-3376","observed_orcids":["https://orcid.org/0000-0002-7959-3376"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann R. Elliott","raw_affiliation_strings":["California Univ. San Diego, CA, United States"],"raw_orcid":"https://orcid.org/0000-0002-7959-3376","affiliations":[{"raw_affiliation_string":"California Univ. San Diego, CA, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112065809","display_name":"Laurence R. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. R. Young","raw_affiliation_strings":["Massachusetts Institute of Technology, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, MA, United States","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01344017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.16259999573230743,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.6299999952316284},{"id":"https://openalex.org/keywords/sleep-disruption","display_name":"sleep disruption","score":0.9340000152587891},{"id":"https://openalex.org/keywords/astronauts","display_name":"astronauts","score":0.6819999814033508},{"id":"https://openalex.org/keywords/space-shuttle-missions","display_name":"Space Shuttle missions","score":0.746999979019165},{"id":"https://openalex.org/keywords/sts-95","display_name":"STS-95","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurolab","display_name":"Neurolab","score":0.781000018119812},{"id":"https://openalex.org/keywords/ambient-light-intensity","display_name":"ambient light intensity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/actigraphy","display_name":"actigraphy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/daytime-alertness","display_name":"daytime alertness","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.9470000267028809},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.5239999890327454},{"id":"https://openalex.org/keywords/sleep-efficiency","display_name":"sleep efficiency","score":0.703000009059906},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4519999921321869},{"id":"https://openalex.org/keywords/circadian-pacemaker","display_name":"circadian pacemaker","score":0.5619999766349792},{"id":"https://openalex.org/keywords/sleep-eeg","display_name":"sleep EEG","score":0.37400001287460327},{"id":"https://openalex.org/keywords/neurobehavioral-performance","display_name":"neurobehavioral performance","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C200678441","wikidata":"https://www.wikidata.org/wiki/Q1423044","display_name":"Alertness","level":2,"score":0.7938225269317627},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7811877131462097},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.7512368559837341},{"id":"https://openalex.org/C2780179797","wikidata":"https://www.wikidata.org/wiki/Q345844","display_name":"Crew","level":2,"score":0.632185697555542},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5122136473655701},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45963603258132935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4317645728588104},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.42945486307144165},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.42787057161331177},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.41901031136512756},{"id":"https://openalex.org/C6439246","wikidata":"https://www.wikidata.org/wiki/Q3332475","display_name":"Aviation medicine","level":2,"score":0.4127802550792694},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3926454186439514},{"id":"https://openalex.org/C178802073","wikidata":"https://www.wikidata.org/wiki/Q8421","display_name":"Aeronautics","level":1,"score":0.21018707752227783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2051520049571991},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17781952023506165},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1551494598388672},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:casi.ntrs.nasa.gov:20000020659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2060/20000020659","pdf_url":"http://hdl.handle.net/2060/20000020659","source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1305493378","host_organization_name":"NASA Headquarters","host_organization_lineage":["https://openalex.org/I1305493378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CASI","raw_type":"Proceedings of the First Biennial Space Biomedical Investigators' Workshop; 544-546"},{"id":"mag:50928386","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20000020659/downloads/20000020659.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1305493378","host_organization_name":"NASA Headquarters","host_organization_lineage":["https://openalex.org/I1305493378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:casi.ntrs.nasa.gov:20000020659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2060/20000020659","pdf_url":"http://hdl.handle.net/2060/20000020659","source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1305493378","host_organization_name":"NASA Headquarters","host_organization_lineage":["https://openalex.org/I1305493378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CASI","raw_type":"Proceedings of the First Biennial Space Biomedical Investigators' Workshop; 544-546"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W50928386.pdf","grobid_xml":"https://content.openalex.org/works/W50928386.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7024528469","https://openalex.org/W1905507378","https://openalex.org/W2074684555","https://openalex.org/W2151805266","https://openalex.org/W152090558","https://openalex.org/W806578597","https://openalex.org/W2159960100","https://openalex.org/W1548328383","https://openalex.org/W7220906331","https://openalex.org/W111483531"],"abstract_inverted_index":{"Sleep":[0],"disruption":[1,134],"and":[2,6,31,65,97,102,167,171,178,214,221,227,237,290,309,328,338,342],"associated":[3,144],"waking":[4,224,339],"sleepiness":[5],"fatigue":[7],"are":[8,84,376],"common":[9],"during":[10,80,179,202,217,286,315],"space":[11,21,136,181,198,208,274,334,367],"flight.":[12],"A":[13],"survey":[14],"of":[15,36,42,49,59,68,115,118,135,152,207,234,243,251,257,270,273,279,304,312,333,366,393],"58":[16],"crew":[17,232],"members":[18,233],"from":[19,28],"nine":[20],"shuttle":[22,182,199],"missions":[23,64,292],"revealed":[24],"that":[25,112,149],"most":[26],"suffered":[27],"sleep":[29,105,133,158,162,165,211,307,316,337],"disruption,":[30,163],"reportedly":[32],"slept":[33],"an":[34,47,370],"average":[35,48],"only":[37],"6.1":[38],"hours":[39,51],"per":[40,52],"day":[41,53],"flight":[43,137,209,335,368],"as":[44,86,245,281,320,322],"compared":[45,348],"to":[46,362,379],"7.9":[50],"on":[54,61,210,254,306,325,336,369],"the":[55,69,119,125,132,140,180,197,205,235,241,255,258,271,277,287,302,313,331,360,364,374,380,394],"ground.":[56],"Nineteen":[57],"percent":[58,67],"crewmembers":[60,70],"single":[62],"shift":[63,73],"50":[66],"in":[71,104,156,175,190,231,262,293,344,352,382],"dual":[72],"operations":[74],"reported":[75],"sleeping":[76],"pill":[77],"usage":[78],"(benzodiazepines)":[79],"their":[81],"missions.":[82,183],"Benzodiazepines":[83],"effective":[85],"hypnotics,":[87],"however,":[88],"not":[89],"without":[90,138],"adverse":[91,141],"side":[92,142],"effects":[93,143,253,303,324,365],"including":[94],"carryover":[95],"sedation":[96],"performance":[98,173,228,343],"impairment,":[99],"anterograde":[100],"amnesia,":[101],"alterations":[103],"EEG.":[106],"Our":[107],"preliminary":[108,387],"ground-based":[109,176,263],"data":[110],"suggest":[111],"pre-sleep":[113,150],"administration":[114,151],"0.3":[116],"mg":[117],"pineal":[120],"hormone":[121],"melatonin":[122,153,222,244,280,305],"may":[123],"have":[124,186],"acute":[126],"hypnotic":[127,247,283],"properties":[128],"needed":[129],"for":[130],"treating":[131],"producing":[139],"with":[145,349],"benzodiazepines.":[146],"We":[147],"hypothesize":[148],"will":[154,317,389],"result":[155],"decreased":[157],"latency,":[159],"reduced":[160],"nocturnal":[161],"improved":[164],"efficiency,":[166],"enhanced":[168],"next-day":[169],"alertness":[170,226,327,341],"cognitive":[172],"both":[174,299],"simulations":[177],"Specifically,":[184],"we":[185],"carried":[187],"out":[188],"experiments":[189],"which:":[191],"(1)":[192],"ambient":[193],"light":[194],"intensity":[195],"aboard":[196],"is":[200,229,248,284,347,359],"assessed":[201,230,249,285],"flight;":[203,275],"(2)":[204],"impact":[206,332,351],"(assessed":[212],"polysomnographically":[213],"actigraphically),":[215],"respiration":[216],"sleep,":[218],"circadian":[219,260],"temperature":[220],"rhythms,":[223],"neurobehavioral":[225,340],"Neurolab":[236],"STS-95":[238,291],"missions;":[239],"(3)":[240],"effectiveness":[242,278],"a":[246,266,282,294,353],"independently":[250],"its":[252,323,350],"phase":[256],"endogenous":[259],"pacemaker":[261],"studies,":[264],"using":[265],"powerful":[267],"experimental":[268],"model":[269],"dyssomnia":[272],"(4)":[276],"STS-90":[288],"(Neurolab)":[289],"double-blind":[295],"placebo-controlled":[296,385],"trial.":[297],"In":[298],"flight-based":[300],"experiments,":[301],"stages":[308],"spectral":[310],"composition":[311],"EEG":[314],"be":[318,390],"determined":[319],"well":[321],"daytime":[326],"performance;":[329],"(5)":[330],"30-45-year-old":[345],"astronauts":[346],"77-year-old":[354],"astronaut.":[355],"This":[356],"case":[357],"study":[358],"first":[361],"assess":[363],"older":[371],"individual.":[372],"Because":[373],"investigators":[375],"still":[377],"blind":[378],"treatment":[381],"this":[383],"double-blind,":[384],"trial,":[386],"results":[388],"presented":[391],"independent":[392],"drug":[395],"condition.":[396]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}