{"id":"https://openalex.org/W508831","doi":null,"title":"Tryptophan in the treatment of late luteal phase dysphoric disorder: a pilot study.","display_name":"Tryptophan in the treatment of late luteal phase dysphoric disorder: a pilot study.","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W508831","mag":"508831","pmid":"https://pubmed.ncbi.nlm.nih.gov/8204563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188575"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1188575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188575","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084337689","display_name":"Susanne Inez Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802905097","display_name":"St Mary's Hospital Centre","ror":"https://ror.org/03s3dhf22","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802905097"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S Steinberg","raw_affiliation_strings":["St. Mary's Hospital, Montr\u00e9al, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Mary's Hospital, Montr\u00e9al, Quebec, Canada","institution_ids":["https://openalex.org/I2802905097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076932433","display_name":"Lawrence Annable","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Annable","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077418824","display_name":"Simon N. Young","orcid":"https://orcid.org/0000-0001-9666-8096","observed_orcids":["https://orcid.org/0000-0001-9666-8096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068113505","display_name":"Mich\u00e8le B\u00e9langer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C B\u00e9langer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.9687,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.96572327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"2","first_page":"114","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.8629999756813049},{"id":"https://openalex.org/keywords/late-luteal-phase-dysphoric-disorder","display_name":"late luteal phase dysphoric disorder","score":0.9399999976158142},{"id":"https://openalex.org/keywords/premenstrual-dysphoric-disorder","display_name":"premenstrual dysphoric disorder","score":0.9409999847412109},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.46000000834465027},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.9210000038146973},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.859000027179718},{"id":"https://openalex.org/keywords/carbohydrate-craving","display_name":"carbohydrate craving","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.4560000002384186},{"id":"https://openalex.org/keywords/symptom-relief","display_name":"symptom relief","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2780820931","wikidata":"https://www.wikidata.org/wiki/Q29299","display_name":"Irritability","level":3,"score":0.8675699830055237},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.8092737793922424},{"id":"https://openalex.org/C2778015638","wikidata":"https://www.wikidata.org/wiki/Q2728811","display_name":"Premenstrual dysphoric disorder","level":4,"score":0.6498299837112427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5363458395004272},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.5288302302360535},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5255640745162964},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4767238199710846},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4663509428501129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4591308534145355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4030757248401642},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.380854994058609},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.36823397874832153},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34096717834472656},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.16853046417236328},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1352909803390503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1090078055858612},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.07704335451126099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008183","descriptor_name":"Luteal Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008183","descriptor_name":"Luteal Phase","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011293","descriptor_name":"Premenstrual Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1188575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},{"id":"pmid:8204563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8204563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatry & neuroscience : JPN","raw_type":"Journal Article"},{"id":"mag:508831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8204563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1188575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1188575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W127217274","https://openalex.org/W215046151","https://openalex.org/W1867338670","https://openalex.org/W1895781480","https://openalex.org/W2013808315","https://openalex.org/W2060486377","https://openalex.org/W2065754499","https://openalex.org/W2067495470","https://openalex.org/W2071487569","https://openalex.org/W2086020698","https://openalex.org/W2110791163","https://openalex.org/W2119850496","https://openalex.org/W2274148752","https://openalex.org/W2405375223","https://openalex.org/W2416958134"],"related_works":["https://openalex.org/W2065754499","https://openalex.org/W148129437","https://openalex.org/W1982016000","https://openalex.org/W81697875","https://openalex.org/W2085681173","https://openalex.org/W193318537","https://openalex.org/W2388081177","https://openalex.org/W7097777378","https://openalex.org/W1252066459","https://openalex.org/W2016415645"],"abstract_inverted_index":{"Thirteen":[0],"patients":[1,44,91],"diagnosed":[2],"during":[3],"two":[4],"menstrual":[5],"cycles":[6],"as":[7,103],"suffering":[8],"from":[9,100],"late":[10,93],"luteal":[11,94],"phase":[12,95],"dysphoric":[13,96],"disorder":[14,97],"were":[15,36,45],"then":[16],"followed":[17],"in":[18,86,90],"an":[19],"open":[20],"pilot":[21],"study":[22,89],"for":[23],"a":[24,58,77,87],"further":[25],"three":[26,41],"cycles.":[27],"During":[28,38],"one":[29],"complete":[30],"cycle,":[31],"baseline":[32],"levels":[33],"of":[34,61,79,82,115],"symptoms":[35,62,101],"obtained.":[37],"the":[39,43],"next":[40],"cycles,":[42],"treated":[46],"with":[47,57,63,92],"L-tryptophan,":[48],"six":[49,80],"grams":[50,81],"per":[51,84],"day.":[52],"L-tryptophan":[53,72,83],"treatment":[54],"was":[55],"associated":[56],"significant":[59],"amelioration":[60],"only":[64],"mild":[65],"side":[66],"effects.":[67],"These":[68],"data":[69],"suggest":[70],"that":[71],"should":[73],"be":[74],"tested":[75],"at":[76],"dose":[78],"day":[85],"placebo-controlled":[88],"who":[98],"suffer":[99],"such":[102],"depression,":[104],"irritability,":[105],"insomnia":[106],"and":[107],"carbohydrate":[108],"craving,":[109],"which":[110],"may":[111],"respond":[112],"to":[113],"potentiation":[114],"serotonin":[116],"function.":[117]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}