{"id":"https://openalex.org/W50800539","doi":null,"title":"Pharmacokinetic and metabolic interrelationships among branched-chain keto and amino acids in humans.","display_name":"Pharmacokinetic and metabolic interrelationships among branched-chain keto and amino acids in humans.","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W50800539","mag":"50800539","pmid":"https://pubmed.ncbi.nlm.nih.gov/4067381"},"language":"en","primary_location":{"id":"pmid:4067381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4067381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019689835","display_name":"PETER SCHAUDER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P Schauder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019689835"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8508,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.68315757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"106","issue":"6","first_page":"701","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/branched-chain-keto-acids","display_name":"branched-chain keto acids","score":0.9769999980926514},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-ketoisocaproate","display_name":"alpha-ketoisocaproate","score":0.972000002861023},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":0.902999997138977},{"id":"https://openalex.org/keywords/isoleucine","display_name":"isoleucine","score":1.0},{"id":"https://openalex.org/keywords/valine","display_name":"valine","score":0.875},{"id":"https://openalex.org/keywords/alpha-ketoisovaleric-acid","display_name":"alpha-ketoisovaleric acid","score":0.871999979019165},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7900000214576721},{"id":"https://openalex.org/keywords/blood-levels","display_name":"blood concentration","score":0.42500001192092896},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.574999988079071},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.9245127439498901},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.9159003496170044},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.8902360200881958},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.8155970573425293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6570932865142822},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6348055601119995},{"id":"https://openalex.org/C2780677274","wikidata":"https://www.wikidata.org/wiki/Q420726","display_name":"Branched-chain amino acid","level":4,"score":0.537483811378479},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5042670965194702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48908287286758423}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000597","descriptor_name":"Amino Acids, Branched-Chain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007651","descriptor_name":"Keto Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007651","descriptor_name":"Keto Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D045782","descriptor_name":"Hemiterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4067381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4067381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:50800539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4067381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W112437049","https://openalex.org/W255152658","https://openalex.org/W647509150","https://openalex.org/W1492348364","https://openalex.org/W1524146987","https://openalex.org/W1577717356","https://openalex.org/W1768353332","https://openalex.org/W1817506345","https://openalex.org/W1984442616","https://openalex.org/W1984442721","https://openalex.org/W1998920564","https://openalex.org/W2030704099","https://openalex.org/W2033524205","https://openalex.org/W2059499117","https://openalex.org/W2060314080","https://openalex.org/W2090123913","https://openalex.org/W2155055881","https://openalex.org/W2284209170","https://openalex.org/W2292008797","https://openalex.org/W2340570451","https://openalex.org/W2402099890","https://openalex.org/W2408810978","https://openalex.org/W2411146669","https://openalex.org/W2412404109","https://openalex.org/W4298048563"],"related_works":["https://openalex.org/W2412404109","https://openalex.org/W2061193929","https://openalex.org/W2094247716","https://openalex.org/W2109432526","https://openalex.org/W2426112911","https://openalex.org/W2167158735","https://openalex.org/W2316033842","https://openalex.org/W2465688886","https://openalex.org/W2084687918","https://openalex.org/W2088829482"],"abstract_inverted_index":{"Equimolar":[0],"loads":[1,116],"(0.55":[2],"mmol/kg)":[3],"of":[4,44,57,66,81,114,117,141],"alpha-ketoisocaproic":[5],"acid":[6,10,23,27,76],"(KICA)":[7],"or":[8,13,74,109,119,130,134,157],"alpha-keto-beta-methyl-n-valeric":[9],"(KMVA),":[11],"leucine,":[12,155],"isoleucine":[14,101,110],"were":[15,47],"given":[16,151],"to":[17,107,112,152],"healthy":[18],"human":[19],"subjects.":[20],"Branched-chain":[21],"keto":[22,69,73,147],"(BCKA)":[24],"and":[25,42,62,86,94,100,143],"amino":[26,60,63,75,168],"(BCAA)":[28],"blood":[29],"levels":[30],"increased":[31,102],"severalfold":[32],"within":[33],"minutes":[34],"for":[35,49,167],"greater":[36],"than":[37,111,166],"3":[38],"hours.":[39],"Time":[40],"course":[41],"magnitude":[43],"the":[45,55,67,82,139,160],"increments":[46],"different":[48],"each":[50],"substance.":[51],"Keto":[52],"acids":[53,64],"augmented":[54],"concentrations":[56,96],"their":[58],"corresponding":[59],"acids,":[61],"those":[65],"respective":[68],"acids.":[70],"Each":[71],"individual":[72],"affected":[77],"all":[78],"other":[79],"constituents":[80],"BCKA-BCAA":[83],"pool.":[84],"KICA":[85,118,129],"leucine":[87,108,131],"greatly":[88],"diminished":[89],"KMVA,":[90],"isoleucine,":[91,156],"alpha-ketoisovaleric":[92],"acid,":[93],"valine":[95,158],"in":[97,105,128,132],"blood.":[98],"Leucine":[99],"significantly":[103,164],"more":[104],"response":[106],"administration":[113],"equimolar":[115],"KMVA.":[120],"The":[121],"data":[122],"suggest":[123],"that":[124],"an":[125],"inappropriate":[126],"increase":[127,153],"BCKA-":[133],"BCAA-containing":[135],"supplements":[136,149],"may":[137],"stimulate":[138],"catabolism":[140],"BCKAs":[142],"BCAAs.":[144],"Furthermore,":[145],"if":[146],"acid-containing":[148,169],"are":[150],"low":[154],"concentrations,":[159],"dose":[161],"must":[162],"be":[163],"higher":[165],"supplements.":[170]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
