{"id":"https://openalex.org/W50777772","doi":"https://doi.org/10.1093/jnen/63.2.97","title":"PKR Activation in Neurodegenerative Disease","display_name":"PKR Activation in Neurodegenerative Disease","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W50777772","doi":"https://doi.org/10.1093/jnen/63.2.97","mag":"50777772","pmid":"https://pubmed.ncbi.nlm.nih.gov/14989595"},"language":"en","primary_location":{"id":"doi:10.1093/jnen/63.2.97","doi":"https://doi.org/10.1093/jnen/63.2.97","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/63.2.97","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017960026","display_name":"Alyson L. Peel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alyson L. Peel","raw_affiliation_strings":["The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA. www.buckinstitute.org","The Buck Institute for Age Research, Novato, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA. www.buckinstitute.org","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"The Buck Institute for Age Research, Novato, California","institution_ids":["https://openalex.org/I1337826666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017960026"],"corresponding_institution_ids":["https://openalex.org/I1337826666"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":0.3988,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.32326821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"63","issue":"2","first_page":"97","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9160000085830688},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8209999799728394},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.9545938372612},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7522984743118286},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5440970063209534},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4911615550518036},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4884745180606842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48341095447540283},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4646785855293274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45100322365760803},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.43494850397109985},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42840784788131714},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.42790770530700684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30455872416496277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2675972878932953},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.17624515295028687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11617773771286011},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.08657574653625488}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnen/63.2.97","doi":"https://doi.org/10.1093/jnen/63.2.97","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/63.2.97","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:14989595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14989595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W25895018","https://openalex.org/W65867874","https://openalex.org/W1488480791","https://openalex.org/W1504003784","https://openalex.org/W1584834830","https://openalex.org/W1596467522","https://openalex.org/W1720681720","https://openalex.org/W1899927719","https://openalex.org/W1934976150","https://openalex.org/W1964173713","https://openalex.org/W1964780858","https://openalex.org/W1973688847","https://openalex.org/W1982832390","https://openalex.org/W1993087535","https://openalex.org/W1996271689","https://openalex.org/W2001558423","https://openalex.org/W2002984957","https://openalex.org/W2007699219","https://openalex.org/W2013806485","https://openalex.org/W2022969546","https://openalex.org/W2042088526","https://openalex.org/W2043349602","https://openalex.org/W2047391267","https://openalex.org/W2048625405","https://openalex.org/W2072595228","https://openalex.org/W2072753625","https://openalex.org/W2073688657","https://openalex.org/W2074783627","https://openalex.org/W2077198961","https://openalex.org/W2080546451","https://openalex.org/W2082245964","https://openalex.org/W2084326871","https://openalex.org/W2084849755","https://openalex.org/W2085622324","https://openalex.org/W2090603241","https://openalex.org/W2092393699","https://openalex.org/W2097096575","https://openalex.org/W2099673459","https://openalex.org/W2100275934","https://openalex.org/W2104502435","https://openalex.org/W2115205812","https://openalex.org/W2121637209","https://openalex.org/W2125172225","https://openalex.org/W2135339028","https://openalex.org/W2135429740","https://openalex.org/W2144475886","https://openalex.org/W2149444093","https://openalex.org/W2164104132","https://openalex.org/W2288430548","https://openalex.org/W2318793010","https://openalex.org/W2330103665"],"related_works":["https://openalex.org/W4409289122","https://openalex.org/W3157053189","https://openalex.org/W1978262065","https://openalex.org/W2113028121","https://openalex.org/W2093616544","https://openalex.org/W2939415331","https://openalex.org/W2623856411","https://openalex.org/W1934976150","https://openalex.org/W2248553755","https://openalex.org/W2090603241"],"abstract_inverted_index":{"Interferon-inducible,":[0],"double-stranded":[1],"RNA-dependent":[2],"protein":[3,39],"kinase":[4],"PKR":[5,19,59,81,94],"is":[6,85],"well":[7],"known":[8,91],"as":[9],"an":[10],"early":[11],"cellular":[12],"responder":[13],"to":[14],"viral":[15],"infection.":[16],"Activation":[17],"of":[18,26,38,42,52,58,93],"has":[20,60],"been":[21,62],"associated":[22],"with":[23],"a":[24,35],"number":[25],"downstream":[27],"cell":[28,31],"stress":[29],"and":[30,47,73,82,95],"death":[32],"events,":[33],"including":[34,68],"generalized":[36],"shutdown":[37],"translation,":[40],"activation":[41,51,57],"caspase-8,":[43],"participation":[44],"in":[45,64,100],"JNK":[46],"p38":[48],"MAPK":[49],"pathways,":[50],"NF-kappaB,":[53],"etc.":[54],"Recently,":[55],"the":[56,78,88],"also":[61],"described":[63],"several":[65],"neurodegenerative":[66],"diseases,":[67],"Huntington":[69],"disease,":[70,72],"Alzheimer":[71],"amyotrophic":[74],"lateral":[75],"sclerosis.":[76],"Although":[77],"relationship":[79],"between":[80,90],"these":[83,101],"diseases":[84],"still":[86],"unclear,":[87],"overlap":[89],"functions":[92],"biochemical":[96],"events":[97],"that":[98],"occur":[99],"neuropathologies":[102],"are":[103],"discussed":[104],"here.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
