{"id":"https://openalex.org/W50703418","doi":null,"title":"A Study of the Aetiology and Epidemiology of Cancers in Teenagers and Young Adults","display_name":"A Study of the Aetiology and Epidemiology of Cancers in Teenagers and Young Adults","publication_year":2011,"publication_date":"2011-03-28","ids":{"openalex":"https://openalex.org/W50703418","mag":"50703418"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/effc3dd6-6655-47cd-af95-6eb26cb055c8","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/effc3dd6-6655-47cd-af95-6eb26cb055c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Doctor of Medicine"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019194593","display_name":"Ramandeep Singh Arora","orcid":"https://orcid.org/0000-0002-2613-4539","observed_orcids":["https://orcid.org/0000-0002-2613-4539"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramandeep Singh Arora","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2613-4539","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019194593"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00631378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescents-and-young-adults","display_name":"adolescents and young adults","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.8399999737739563},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/germ-cell-tumors","display_name":"germ cell tumors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bone-tumors","display_name":"bone tumors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pilocytic-astrocytoma","display_name":"pilocytic astrocytoma","score":0.7850000262260437},{"id":"https://openalex.org/keywords/embryonal-tumors","display_name":"embryonal tumors","score":0.6290000081062317},{"id":"https://openalex.org/keywords/pituitary-tumors","display_name":"pituitary tumors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pleomorphic-xanthoastrocytoma","display_name":"pleomorphic xanthoastrocytoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/testicular-cancer","display_name":"testicular cancer","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.45399999618530273},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.4399999976158142},{"id":"https://openalex.org/keywords/colon-and-rectum-cancer","display_name":"colon and rectum cancer","score":0.5740000009536743},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.5210000276565552},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6578229069709778},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6403005123138428},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6169009208679199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5962205529212952},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5876694917678833},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5545689463615417},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.48065221309661865},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.4678047001361847},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4433954060077667},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4122955799102783},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39837104082107544},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3937492072582245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38838082551956177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38131362199783325},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36643874645233154},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08409926295280457},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/effc3dd6-6655-47cd-af95-6eb26cb055c8","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/effc3dd6-6655-47cd-af95-6eb26cb055c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Doctor of Medicine"},{"id":"mag:50703418","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538429","pdf_url":null,"source":{"id":"https://openalex.org/S4306532716","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2011.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2011.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":168,"referenced_works":["https://openalex.org/W93927356","https://openalex.org/W125193443","https://openalex.org/W140268124","https://openalex.org/W181324718","https://openalex.org/W435793688","https://openalex.org/W1480878209","https://openalex.org/W1492157159","https://openalex.org/W1512765211","https://openalex.org/W1515178591","https://openalex.org/W1529983368","https://openalex.org/W1582554697","https://openalex.org/W1594566016","https://openalex.org/W1677573439","https://openalex.org/W1844671708","https://openalex.org/W1863005346","https://openalex.org/W1885667275","https://openalex.org/W1932428064","https://openalex.org/W1964513986","https://openalex.org/W1965227983","https://openalex.org/W1965745036","https://openalex.org/W1968370267","https://openalex.org/W1969608508","https://openalex.org/W1971108120","https://openalex.org/W1973020397","https://openalex.org/W1974196659","https://openalex.org/W1978319863","https://openalex.org/W1982585616","https://openalex.org/W1984535150","https://openalex.org/W1985455449","https://openalex.org/W1985550793","https://openalex.org/W1985841941","https://openalex.org/W1987029250","https://openalex.org/W1988836428","https://openalex.org/W1989851932","https://openalex.org/W1993989713","https://openalex.org/W1994514632","https://openalex.org/W1997389854","https://openalex.org/W1997648913","https://openalex.org/W1999479708","https://openalex.org/W2000217892","https://openalex.org/W2000259265","https://openalex.org/W2001808061","https://openalex.org/W2004264592","https://openalex.org/W2006053987","https://openalex.org/W2006691249","https://openalex.org/W2008183667","https://openalex.org/W2010018343","https://openalex.org/W2010039539","https://openalex.org/W2011289542","https://openalex.org/W2015167298","https://openalex.org/W2020830322","https://openalex.org/W2025148927","https://openalex.org/W2025543199","https://openalex.org/W2025989401","https://openalex.org/W2026084160","https://openalex.org/W2028354370","https://openalex.org/W2028485234","https://openalex.org/W2030969771","https://openalex.org/W2031484405","https://openalex.org/W2031829239","https://openalex.org/W2036694127","https://openalex.org/W2037328559","https://openalex.org/W2037555056","https://openalex.org/W2041210343","https://openalex.org/W2041889165","https://openalex.org/W2044414901","https://openalex.org/W2046895737","https://openalex.org/W2047287091","https://openalex.org/W2049419026","https://openalex.org/W2050249291","https://openalex.org/W2051365292","https://openalex.org/W2051611229","https://openalex.org/W2052231391","https://openalex.org/W2052917591","https://openalex.org/W2053563324","https://openalex.org/W2055312920","https://openalex.org/W2056401063","https://openalex.org/W2059238995","https://openalex.org/W2061069756","https://openalex.org/W2061655178","https://openalex.org/W2061713456","https://openalex.org/W2065876208","https://openalex.org/W2067570591","https://openalex.org/W2069351898","https://openalex.org/W2069856178","https://openalex.org/W2075037489","https://openalex.org/W2077241223","https://openalex.org/W2077691937","https://openalex.org/W2078317192","https://openalex.org/W2079051189","https://openalex.org/W2080725243","https://openalex.org/W2081606003","https://openalex.org/W2086313837","https://openalex.org/W2090728148","https://openalex.org/W2091525701","https://openalex.org/W2091891960","https://openalex.org/W2093946326","https://openalex.org/W2094246631","https://openalex.org/W2095075675","https://openalex.org/W2096208059","https://openalex.org/W2096758188","https://openalex.org/W2098438435","https://openalex.org/W2100246928","https://openalex.org/W2107328434","https://openalex.org/W2109085434","https://openalex.org/W2109680952","https://openalex.org/W2110150980","https://openalex.org/W2110475285","https://openalex.org/W2110579981","https://openalex.org/W2111229057","https://openalex.org/W2112489360","https://openalex.org/W2113250301","https://openalex.org/W2113751957","https://openalex.org/W2114761476","https://openalex.org/W2115081384","https://openalex.org/W2118055149","https://openalex.org/W2119272857","https://openalex.org/W2120343071","https://openalex.org/W2121120778","https://openalex.org/W2122911655","https://openalex.org/W2125435699","https://openalex.org/W2130297731","https://openalex.org/W2130885525","https://openalex.org/W2131111598","https://openalex.org/W2131871201","https://openalex.org/W2132255205","https://openalex.org/W2132595749","https://openalex.org/W2135513858","https://openalex.org/W2138819243","https://openalex.org/W2144589754","https://openalex.org/W2144991904","https://openalex.org/W2146098561","https://openalex.org/W2146818253","https://openalex.org/W2152525323","https://openalex.org/W2153662176","https://openalex.org/W2154683287","https://openalex.org/W2156253770","https://openalex.org/W2157075165","https://openalex.org/W2157636873","https://openalex.org/W2158633101","https://openalex.org/W2158922990","https://openalex.org/W2161888675","https://openalex.org/W2162996009","https://openalex.org/W2164157837","https://openalex.org/W2168502324","https://openalex.org/W2168595549","https://openalex.org/W2169370687","https://openalex.org/W2170152883","https://openalex.org/W2170521505","https://openalex.org/W2171442390","https://openalex.org/W2172063734","https://openalex.org/W2182638277","https://openalex.org/W2189295655","https://openalex.org/W2224171426","https://openalex.org/W2225370588","https://openalex.org/W2232773455","https://openalex.org/W2290326436","https://openalex.org/W2313149597","https://openalex.org/W2336407947","https://openalex.org/W2339501506","https://openalex.org/W2399800064","https://openalex.org/W2405537595","https://openalex.org/W2413198262","https://openalex.org/W2413873989","https://openalex.org/W2416068498","https://openalex.org/W2466489612","https://openalex.org/W2472553326","https://openalex.org/W2490949445"],"related_works":["https://openalex.org/W2135513858","https://openalex.org/W7096410199","https://openalex.org/W2782191699","https://openalex.org/W1999699838","https://openalex.org/W2071067418","https://openalex.org/W2604799227","https://openalex.org/W4220685048","https://openalex.org/W2553118769","https://openalex.org/W3108145228","https://openalex.org/W1995117457"],"abstract_inverted_index":{"IntroductionLittle":[0],"is":[1,21,99,730],"known":[2],"about":[3],"the":[4,22,78,87,146,149,176,199,224,233,310,365,419,430,461,504,518,526,529,538,556,560,564,581,592,601,639,642,672,715,733],"aetiology":[5,131],"of":[6,26,70,81,128,132,148,161,183,198,235,239,255,263,272,285,309,332,341,357,370,373,388,402,473,498,500,503,521,528,537,544,559,569,594,600,613,641,661,670,677,683,692,698,711,735],"cancer":[7,20,119,133,153,167,192,264,595,651],"in":[8,18,29,84,94,111,113,122,134,179,265,268,322,327,362,364,385,393,398,411,429,436,441,454,465,481,493,525,534,596,609,627,644,666,674,686,732],"teenagers":[9],"and":[10,47,64,86,93,104,170,204,211,241,290,292,299,314,335,353,367,372,378,418,445,449,457,468,483,615,630,635,705,717],"young":[11],"adults":[12],"(TYA)":[13],"aged":[14],"15-24":[15],"years,":[16],"although":[17],"England,":[19,324],"most":[23,34,279],"common":[24,35,681],"cause":[25],"disease-related":[27],"mortality":[28,121],"this":[30,38,74,135,305,587,736],"age":[31,39,136,480,492],"group.":[32],"The":[33,52,97,495,541,567,708],"cancers":[36,83,284,294,308,663],"at":[37,56,260,424,475,487,513,548,563,572,580,724],"are":[40],"lymphomas,":[41],"central":[42,530],"nervous":[43],"system":[44],"(CNS)":[45],"tumours":[46,50,106,257,326,337,359,464,685],"germ":[48],"cell":[49],"(GCT).":[51],"commonest":[53],"carcinomas":[54],"seen":[55,89,423,665],"older":[57,616,667],"ages":[58,163,401],"including":[59,282,295],"lung,":[60,286],"breast,":[61,288],"large":[62],"bowel":[63],"prostate":[65],"account":[66],"for":[67,196,278,752],"only":[68],"3-4%":[69],"TYA":[71,85,114,266,328,466,597],"cancers.":[72,618],"In":[73],"thesis":[75,588],"I":[76,589],"describe":[77],"incidence":[79,112,177,207,262,319,363,384,399,421,474,497,520,645,709],"patterns":[80,178,646,676,710],"selected":[82],"variation":[88],"with":[90,164,181,237,258,546,574,653,689,714,720],"geography,":[91],"time":[92],"population":[95,190,227],"subgroups.":[96],"focus":[98],"on":[100,158,249],"CNS":[101,325,343,358,374],"tumours,":[102,346,349],"GCT":[103,392],"bone":[105,463,728],"as":[107,695],"they":[108],"either":[109],"peak":[110,361,383,397,420,472,486,496,519],"and/or":[115],"contribute":[116],"disproportionately":[117],"to":[118,223,304,404,426,433,439,451,477,489,552,624,650,658,746],"related":[120],"TYA.":[123,386],"This":[124,274,413],"will":[125],"allow":[126],"formulation":[127],"hypotheses":[129],"regarding":[130],"group":[137],"which":[138,251,380,407,604,742],"can":[139,637],"then":[140],"be":[141,553,744,750],"tested":[142],"by":[143,416],"further":[144],"research.MethodsFor":[145],"majority":[147,640],"analysis,":[150],"anonymised":[151],"national":[152],"registration":[154],"data":[155,185],"from":[156,186],"England":[157,180,269,394,634],"individual":[159,280],"patients":[160,545],"all":[162],"newly":[165],"diagnosed":[166],"between":[168,400,633],"1979":[169],"2003":[171],"were":[172,194,209,221,307,329,460],"used.":[173],"To":[174,231],"contrast":[175],"that":[182,271,360,512,727],"India,":[184],"five":[187],"Indian":[188],"urban":[189],"based":[191],"registries":[193],"used":[195,608],"part":[197],"analysis.":[200],"Age,":[201],"sex,":[202],"site":[203,389,417,516],"histology":[205],"specific":[206],"rates":[208,691],"calculated":[210],"expressed":[212],"per":[213],"million":[214],"person":[215],"years.":[216],"All":[217],"rates,":[218],"where":[219,318],"appropriate,":[220],"adjusted":[222],"world":[225],"standard":[226],"using":[228,598],"direct":[229],"methods.":[230],"explore":[232],"link":[234],"growth":[236,729,747],"development":[238,734],"osteosarcoma":[240,499,547,712],"Ewing":[242,458,522,575,753],"sarcoma,":[243],"a":[244,330,382,396,470,484,680,696,721],"random-effects":[245],"meta-analysis":[246],"was":[247,275,320,408,422,507,550,577],"undertaken":[248],"studies":[250,620],"investigated":[252],"an":[253],"association":[254,568,719],"these":[256,684],"height":[259,543,558,571,723],"diagnosisResultsThe":[261],"overall":[267],"exceeded":[270,532],"India.":[273],"also":[276,578,749],"true":[277],"sites":[281],"epithelial":[283],"colon/rectum,":[287],"ovary":[289],"cervix,":[291],"non-epithelial":[293],"melanoma,":[296],"Hodgkin":[297],"lymphoma":[298],"testicular":[300,455],"cancer.":[301],"Notable":[302],"exceptions":[303],"pattern":[306],"mouth,":[311],"gall":[312],"bladder":[313],"stomach":[315],"(females":[316],"only)":[317],"higher":[321],"India.In":[323],"composite":[331],"pilocytic":[333],"astrocytomas":[334,352],"embryonal":[336],"(representing":[338,355],"tail":[339],"end":[340],"childhood":[342,614],"tumours),":[344],"pituitary":[345],"nerve":[347],"sheath":[348],"high":[350],"grade":[351],"meningiomas":[354],"early-onset":[356],"6th":[366],"7th":[368],"decade":[369],"life),":[371],"GCTs,":[375],"pleomorphic":[376],"xanthoastrocytomas":[377],"neurocytomas":[379],"show":[381],"Irrespective":[387],"or":[390,701],"histology,":[391],"showed":[395,469],"10":[403,425,476],"39":[405],"years":[406,428,435,453,479,491],"more":[409,510],"marked":[410],"males.":[412,494],"however":[414],"varied":[415],"14":[427,478],"CNS,":[431],"15":[432,488],"19":[434,490],"ovary,":[437],"25":[438],"29":[440],"mediastinum":[442],"&":[443,447],"thorax":[444],"abdomen":[446],"pelvis,":[448],"30":[450],"34":[452],"tumours.Osteosarcoma":[456],"sarcoma":[459,576],"predominant":[462],"inEngland":[467],"distinct":[471],"females":[482],"larger":[485],"long":[501,535],"bones":[502,527,536],"lower":[505,539],"limb":[506],"six":[508],"times":[509],"than":[511],"any":[514],"other":[515],"while":[517,738],"sarcomas":[523],"located":[524],"axis":[531],"those":[533],"limb.":[540],"average":[542,557],"diagnosis":[549,573,725],"found":[551],"significantly":[554],"above":[555],"reference":[561],"population,":[562],"95%":[565,582],"level.":[566],"greater":[570,722],"significant":[579],"level":[583],"but":[584],"much":[585],"weaker.ConclusionIn":[586],"have":[590,605],"explored":[591],"epidemiology":[593],"some":[599,622,662],"established":[602],"methodologies":[603],"previously":[606],"been":[607],"advancing":[610],"our":[611],"knowledge":[612],"adult":[617],"These":[619],"provide":[621],"clues":[623],"aetiology.":[625],"Variation":[626],"environmental":[628],"exposures":[629],"lifestyle":[631],"factors":[632,700],"India":[636],"explain":[638],"differences":[643],"observed.":[647],"Genetic":[648],"predisposition":[649],"along":[652,713],"carcinogen":[654],"exposure":[655],"could":[656,748],"lead":[657],"early":[659],"onset":[660],"generally":[664],"adults.":[668],"Regardless":[669],"site,":[671],"similarity":[673],"age-incidence":[675],"GCT,":[678],"suggests":[679],"initiation":[682],"embryonic/foetal":[687],"life":[688],"variable":[690],"tumour":[693,737],"progression":[694],"result":[697],"local":[699],"events":[702],"during":[703],"postnatal":[704],"pubertal":[706],"period.":[707],"strong":[716],"consistent":[718],"indicate":[726],"important":[731],"different":[739],"biological":[740],"pathways":[741],"may":[743],"unrelated":[745],"relevant":[751],"sarcoma.":[754]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}