{"id":"https://openalex.org/W50652269","doi":null,"title":"Behaviour of osteoclasts in vitro: contact behaviour of osteoclasts with osteoblast-like cells and networking of osteoclasts for 3D orientation.","display_name":"Behaviour of osteoclasts in vitro: contact behaviour of osteoclasts with osteoblast-like cells and networking of osteoclasts for 3D orientation.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W50652269","mag":"50652269","pmid":"https://pubmed.ncbi.nlm.nih.gov/1295866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259723"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1523163","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259723","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026235186","display_name":"Pavel Vesel\u00fd","orcid":"https://orcid.org/0000-0003-3420-395X","observed_orcids":["https://orcid.org/0000-0003-3420-395X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Vesely","raw_affiliation_strings":["Department of Anatomy and Developmental Biology, University College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Developmental Biology, University College London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091749009","display_name":"ALAN BOYDE","orcid":"https://orcid.org/0000-0002-9871-5498","observed_orcids":["https://orcid.org/0000-0002-9871-5498","https://orcid.org/0000-0001-7136-4694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Boyde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103467611","display_name":"Sheila J. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2235,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.38998338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"181 ( Pt 2)","issue":null,"first_page":"277","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/osteoblast-like-cells","display_name":"osteoblast-like cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.9079999923706055},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/contact-guidance","display_name":"contact guidance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cell-orientation","display_name":"cell orientation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.8320000171661377},{"id":"https://openalex.org/keywords/rat-bone","display_name":"rat bone","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.8606470823287964},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6917999982833862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6334673762321472},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5252601504325867},{"id":"https://openalex.org/C64979461","wikidata":"https://www.wikidata.org/wiki/Q3151077","display_name":"Contact inhibition","level":3,"score":0.5211796164512634},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4872550070285797},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.4826672375202179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47175198793411255},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.4602813124656677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2997424006462097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08970513939857483}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014741","descriptor_name":"Video Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:europepmc.org:1523163","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:1295866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1295866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anatomy","raw_type":"Journal Article"},{"id":"mag:50652269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1295866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1523163","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1259723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1424085260","https://openalex.org/W1986085679","https://openalex.org/W1997878596","https://openalex.org/W2018634464","https://openalex.org/W2034977978","https://openalex.org/W2038532074","https://openalex.org/W2040337853","https://openalex.org/W2049327162","https://openalex.org/W2060292013","https://openalex.org/W2065620148","https://openalex.org/W2066488281","https://openalex.org/W2070271067","https://openalex.org/W2083706866","https://openalex.org/W2141541585","https://openalex.org/W2397451144","https://openalex.org/W2412770704","https://openalex.org/W2412816629","https://openalex.org/W2417734181","https://openalex.org/W2426842961","https://openalex.org/W2473001910","https://openalex.org/W4254656286"],"related_works":["https://openalex.org/W3034973495","https://openalex.org/W2063345796","https://openalex.org/W2035723046","https://openalex.org/W2034319040","https://openalex.org/W2071767963","https://openalex.org/W2094859878","https://openalex.org/W1988529265","https://openalex.org/W2154216995","https://openalex.org/W2914366761","https://openalex.org/W2162997702"],"abstract_inverted_index":{"The":[0,155,189],"cell-cell":[1],"contact-induced":[2],"behaviour":[3,53,193],"of":[4,17,35,43,48,68,86,91,105,118,134,163,182,191,199,207],"osteoclasts":[5,18,56,110,124,200],"and":[6,46,57,89,130,136,139,178],"osteoblasts":[7],"in":[8,66,102,112,114,147,210],"vitro":[9],"was":[10],"investigated":[11],"by":[12,94,109,128],"time-lapse":[13],"videomicroscopy.":[14],"Contact":[15],"interactions":[16],"with":[19],"autologous":[20,58],"cells,":[21,45,165],"derived":[22],"mostly":[23],"from":[24,28],"chick":[25],"but":[26],"also":[27],"rat":[29],"bones,":[30],"included":[31],"contact":[32,36,38,52],"inhibition,":[33,37],"failure":[34],"guidance":[39],"along":[40,144],"stabilised":[41],"edges":[42],"other":[44,49,164],"underlapping":[47],"cells.":[50,120],"Message-mediated":[51],"(MMCB)":[54],"between":[55],"osteoblastic":[59,107],"cells":[60],"resulted,":[61],"after":[62,78],"a":[63,100,173,197],"time":[64],"delay,":[65],"zeiosis":[67],"the":[69,79,87,95,103,106,115,145,161,168,180,183,186,204],"osteoblast-like":[70],"cell":[71,88,184],"which":[72],"could":[73,142],"continue,":[74],"or":[75,122,150,166],"even":[76],"begin,":[77],"osteoclast":[80],"broke":[81],"contact,":[82],"leading":[83],"to":[84,160,167,185],"retraction":[85],"occupation":[90],"its":[92],"position":[93],"osteoclast.":[96],"MMCB":[97],"may":[98],"play":[99],"part":[101],"breaching":[104],"sheet":[108],"and,":[111],"general,":[113],"malignant":[116],"spread":[117],"neoplastic":[119],"Two":[121],"more":[123],"were":[125],"often":[126],"joined":[127],"connecting":[129],"coordinating":[131],"tubules":[132],"(CCTs)":[133],"varied,":[135],"varying,":[137],"lengths":[138],"widths.":[140],"Osteoclasts":[141],"travel":[143],"CCTs":[146,156],"both":[148],"directions,":[149],"send":[151],"nuclei":[152],"through":[153],"them.":[154],"became":[157],"temporarily":[158],"attached":[159],"surface":[162],"substrate,":[169],"then":[170],"acting":[171],"as":[172],"temporary":[174],"anchorage":[175],"for":[176,179,203],"orientation":[177],"return":[181],"same":[187],"spot.":[188],"dynamics":[190],"osteoclastic":[192],"suggest":[194],"that":[195],"such":[196],"networking":[198],"is":[201],"valuable":[202],"3D":[205],"coordination":[206],"their":[208],"role":[209],"bone":[211],"turnover.":[212]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}