{"id":"https://openalex.org/W50504535","doi":null,"title":"Genetic variants detected among 106 lymphocyte polypeptides observed in two-dimensional gels.","display_name":"Genetic variants detected among 106 lymphocyte polypeptides observed in two-dimensional gels.","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W50504535","mag":"50504535","pmid":"https://pubmed.ncbi.nlm.nih.gov/3766538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1683961"},"language":"en","primary_location":{"id":"pmid:3766538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3766538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040156444","display_name":"Samir Hanash","orcid":"https://orcid.org/0000-0002-4210-1593","observed_orcids":["https://orcid.org/0000-0002-4210-1593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Hanash","raw_affiliation_strings":["Clinical Cancer Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cancer Prevention","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041569085","display_name":"Leslie J. Baier","orcid":"https://orcid.org/0000-0002-8773-9670","observed_orcids":["https://orcid.org/0000-0002-8773-9670"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L J Baier","raw_affiliation_strings":["University of Michigan , Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan , Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056217370","display_name":"Danny R. Welch","orcid":"https://orcid.org/0000-0002-1951-4947","observed_orcids":["https://orcid.org/0000-0002-1951-4947"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Welch","raw_affiliation_strings":["University of Michigan , Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan , Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059668814","display_name":"Rork D. Kuick","orcid":"https://orcid.org/0000-0002-8817-5192","observed_orcids":["https://orcid.org/0000-0002-8817-5192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kuick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109945938","display_name":"M M Galteau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Galteau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5323,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88442103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"3","first_page":"317","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7120000123977661},{"id":"https://openalex.org/keywords/protein-variants","display_name":"protein variants","score":0.6389999985694885},{"id":"https://openalex.org/keywords/two-dimensional-electrophoresis","display_name":"two-dimensional gel electrophoresis","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7689242362976074},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.6193141341209412},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.6107454895973206},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.6085543036460876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5503841042518616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5429053902626038},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4604772627353668},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.4338746666908264},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.4294756352901459},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.42385879158973694},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4216718375682831},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3835030794143677},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.33937567472457886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2521268129348755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22148945927619934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18263086676597595},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07930338382720947}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3766538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3766538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:50504535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3766538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3350296581","display_name":"PROTEIN PATTERNS IN LEUKEMIC CELLS","funder_award_id":"R01CA032146","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5128817692","display_name":"HUMAN MUTATION","funder_award_id":"P01CA026803","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W104700123","https://openalex.org/W124976166","https://openalex.org/W1044048047","https://openalex.org/W1606423922","https://openalex.org/W1880918882","https://openalex.org/W1893971962","https://openalex.org/W1951959739","https://openalex.org/W2010147467","https://openalex.org/W2014321075","https://openalex.org/W2085354511","https://openalex.org/W2092297202","https://openalex.org/W2343297194","https://openalex.org/W2396062707","https://openalex.org/W4300519049"],"related_works":["https://openalex.org/W2085354511","https://openalex.org/W2034318888","https://openalex.org/W124976166","https://openalex.org/W2977869754","https://openalex.org/W2343297194","https://openalex.org/W2092297202","https://openalex.org/W2117903086","https://openalex.org/W2122643138","https://openalex.org/W104700123","https://openalex.org/W1437687654"],"abstract_inverted_index":{"Peripheral":[0],"blood":[1],"lymphocytes":[2],"from":[3,35,43],"40":[4,37],"children":[5],"have":[6],"been":[7],"examined":[8,48],"for":[9],"genetic":[10,29,52,74,124],"variation":[11,125],"in":[12,33,76,104,126],"their":[13],"protein":[14,128],"constituents":[15],"by":[16],"two-dimensional":[17],"polyacrylamide":[18],"gel":[19],"electrophoresis.":[20],"One":[21,83],"hundred":[22,84],"six":[23],"polypeptides":[24,72,88],"chosen":[25],"without":[26],"respect":[27],"to":[28,49],"variability":[30],"were":[31,46,102],"scored":[32,67,89],"gels":[34,42],"the":[36,51,58,71,81,91,109,112],"children.":[38,82],"For":[39],"each":[40],"child,":[41],"both":[44],"parents":[45,110],"also":[47],"substantiate":[50],"basis":[53],"of":[54,60,70,80,86,93,108,111,116],"variants":[55,75,101],"observed.":[56],"Of":[57],"total":[59],"4,240":[61],"polypeptides,":[62],"23":[63],"could":[64],"not":[65],"be":[66],"unambiguously.":[68],"Fourteen":[69],"showed":[73],"one":[77,107],"or":[78],"more":[79],"twenty-nine":[85],"4,217":[87],"exhibited":[90],"combination":[92],"a":[94,97],"normal":[95],"and":[96],"variant":[98],"polypeptide.":[99],"All":[100],"present":[103],"at":[105],"least":[106],"subject.":[113],"The":[114],"index":[115],"heterozygosity":[117],"observed":[118],"(3.05%":[119],"+/-":[120],".23%)":[121],"indicates":[122],"substantial":[123],"cellular":[127],"constituents.":[129]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
