{"id":"https://openalex.org/W5038923","doi":"https://doi.org/10.1007/bfb0114312","title":"Biosensors based on surface concentration measuring devices \u2014 The concept of surface concentration","display_name":"Biosensors based on surface concentration measuring devices \u2014 The concept of surface concentration","publication_year":2007,"publication_date":"2007-12-04","ids":{"openalex":"https://openalex.org/W5038923","doi":"https://doi.org/10.1007/bfb0114312","mag":"5038923"},"language":"en","primary_location":{"id":"doi:10.1007/bfb0114312","doi":"https://doi.org/10.1007/bfb0114312","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bfb0114312","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Colloid & Polymer Science","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W619198006","display_name":"Surfactants, Adsorption, Surface Spectroscopy and Disperse Systems"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113656085","display_name":"Ulf J\u00f6nsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291458624","display_name":"Swedish Defence Research Agency","ror":"https://ror.org/0470cgs30","country_code":"SE","type":"funder","lineage":["https://openalex.org/I1291458624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"U. J\u00f6nsson","raw_affiliation_strings":["Laboratory of Applied Physics, National Defence Research Institute, Department 4, S-90182, Ume\u00e5, Sweden","Laboratory of Applied Physics, National Defence Research Institute, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Physics, National Defence Research Institute, Department 4, S-90182, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]},{"raw_affiliation_string":"Laboratory of Applied Physics, National Defence Research Institute, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010259351","display_name":"Magnus Malmqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291458624","display_name":"Swedish Defence Research Agency","ror":"https://ror.org/0470cgs30","country_code":"SE","type":"funder","lineage":["https://openalex.org/I1291458624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Malmqvist","raw_affiliation_strings":["Division of Radiation Biology, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","Division of Radiation Biology, National Defence Research Institute, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biology, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]},{"raw_affiliation_string":"Division of Radiation Biology, National Defence Research Institute, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023498392","display_name":"Inger R\u00f6nnberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291458624","display_name":"Swedish Defence Research Agency","ror":"https://ror.org/0470cgs30","country_code":"SE","type":"funder","lineage":["https://openalex.org/I1291458624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"I. R\u00f6nnberg","raw_affiliation_strings":["Division of Experimental Medicine, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","Division of Experimental Medicine, National Defence Research Institute, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Medicine, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]},{"raw_affiliation_string":"Division of Experimental Medicine, National Defence Research Institute, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037094810","display_name":"Lars E. R. BERGHEM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291458624","display_name":"Swedish Defence Research Agency","ror":"https://ror.org/0470cgs30","country_code":"SE","type":"funder","lineage":["https://openalex.org/I1291458624"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Berghem","raw_affiliation_strings":["Division of Experimental Medicine, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","Division of Experimental Medicine, National Defence Research Institute, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Medicine, National Defence Research Institute, Department 4, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]},{"raw_affiliation_string":"Division of Experimental Medicine, National Defence Research Institute, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I1291458624"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1291458624"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.00142542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"96","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosensor","display_name":"immunosensor","score":0.824999988079071},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.753000020980835},{"id":"https://openalex.org/keywords/antibody-immobilization","display_name":"antibody immobilization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antibody-antigen-interaction","display_name":"antigen-antibody reaction","score":0.7680000066757202},{"id":"https://openalex.org/keywords/in-situ-ellipsometry","display_name":"in situ ellipsometry","score":0.8870000243186951},{"id":"https://openalex.org/keywords/multivalency","display_name":"multivalency","score":0.6809999942779541},{"id":"https://openalex.org/keywords/antibody-purification","display_name":"antibody purification","score":0.6949999928474426},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.7668373584747314},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7355546355247498},{"id":"https://openalex.org/C18293161","wikidata":"https://www.wikidata.org/wiki/Q898774","display_name":"Ellipsometry","level":3,"score":0.7027007937431335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6117949485778809},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5420239567756653},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4886966049671173},{"id":"https://openalex.org/C2994054872","wikidata":"https://www.wikidata.org/wiki/Q3489404","display_name":"Solid surface","level":2,"score":0.4449552595615387},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4198690950870514},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38511133193969727},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3657134771347046},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29356682300567627},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2384921908378601},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19709378480911255},{"id":"https://openalex.org/C19067145","wikidata":"https://www.wikidata.org/wiki/Q1137203","display_name":"Thin film","level":2,"score":0.09760305285453796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09726408123970032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07736411690711975},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.07089468836784363},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.06086766719818115},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/bfb0114312","doi":"https://doi.org/10.1007/bfb0114312","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bfb0114312","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Colloid & Polymer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W72670338","https://openalex.org/W1569512084","https://openalex.org/W1614173972","https://openalex.org/W1773975057","https://openalex.org/W1948792875","https://openalex.org/W1963680493","https://openalex.org/W2008411066","https://openalex.org/W2010953277","https://openalex.org/W2014870763","https://openalex.org/W2015303565","https://openalex.org/W2018163846","https://openalex.org/W2034010375","https://openalex.org/W2056774292","https://openalex.org/W2060516954","https://openalex.org/W2065948470","https://openalex.org/W2067726083","https://openalex.org/W2081917674","https://openalex.org/W2084471063","https://openalex.org/W2084855813","https://openalex.org/W2156313755","https://openalex.org/W2316145694"],"related_works":["https://openalex.org/W2010509445","https://openalex.org/W2097200209","https://openalex.org/W4210808150","https://openalex.org/W1984668005","https://openalex.org/W2102283981","https://openalex.org/W2102501548","https://openalex.org/W2076905781","https://openalex.org/W1986679684","https://openalex.org/W1992274324","https://openalex.org/W2079628431"],"abstract_inverted_index":{"Surface":[0],"concentration":[1,15,44,79,150],"measuring":[2,45,80],"devices":[3,11],"allow":[4],"direct":[5],"measurement":[6],"of":[7,31,49,54,87,129,151,166,168],"biomolecular":[8],"interactions.":[9],"These":[10],"measure":[12],"the":[13,29,52,61,64,83,115,119,127,140,164,169,174],"surface":[14,43,78,93,149],"of,":[16],"for":[17,42,51],"example,":[18],"interacting":[19,153],"antigens":[20],"or":[21],"antibodies":[22,50,109,120,156,170],"at":[23,91],"solid":[24],"surfaces.":[25],"We":[26],"here":[27],"exemplify":[28],"importance":[30],"using":[32],"highly":[33],"purified":[34],"molecules":[35],"together":[36],"with":[37,108,154],"an":[38,76],"optimized":[39],"immobilization":[40,48,175],"technique":[41,81],"immunosensors.":[46],"The":[47,68,148],"detection":[53],"human":[55],"plasma":[56],"fibronectin":[57,101,135,152],"was":[58,66,70,97,124,157],"compared":[59,113,138],"to":[60,102,114,139,159],"reverse":[62,116],"where":[63,118],"antigen":[65,142],"immobilized.":[67,122],"result":[69],"evaluated":[71],"by":[72,126],"in":[73,85,110],"situ":[74],"ellipsometry,":[75],"optical":[77],"whereby":[82],"changes":[84],"polarization":[86],"light":[88],"on":[89,133,145,163,173],"reflection":[90],"a":[92,103],"is":[94],"measured.":[95],"It":[96],"found":[98,158],"that":[99],"immobilized":[100,155],"much":[104],"greater":[105],"extent":[106],"interacted":[107],"solution":[111],"as":[112,137],"situation":[117],"were":[121],"This":[123],"explained":[125],"multivalency":[128],"antibody":[130],"binding":[131,143],"sites":[132,144],"each":[134,146],"molecule":[136],"two":[141],"antibody.":[147],"depend":[160],"not":[161],"only":[162],"degree":[165],"purification":[167],"but":[171],"also":[172],"technique.":[176]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}