{"id":"https://openalex.org/W50353905","doi":null,"title":"Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model.","display_name":"Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W50353905","mag":"50353905","pmid":"https://pubmed.ncbi.nlm.nih.gov/15517889"},"language":"en","primary_location":{"id":"pmid:15517889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15517889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109301332","display_name":"Christian Liebau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160608","display_name":"Asklepios","ror":"https://ror.org/055tk9p53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210160608"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Liebau","raw_affiliation_strings":["Department of Orthopaedic Surgery, Asklepios Clinic, 38667 Bad Harzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Asklepios Clinic, 38667 Bad Harzburg, Germany","institution_ids":["https://openalex.org/I4210160608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048990052","display_name":"Christian Roesel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Roesel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sebastian Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052965071","display_name":"Christiaan Karreman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christiaan Karreman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000005212","display_name":"Johannes Bernd Prisack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes Bernd Prisack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039660568","display_name":"Hans Bojar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Bojar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083637762","display_name":"Harry Rudolf Merk","orcid":"https://orcid.org/0000-0002-2002-2608","observed_orcids":["https://orcid.org/0000-0002-2002-2608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry Merk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010359340","display_name":"Neumann Wolfram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neumann Wolfram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109961409","display_name":"Axel W.A. Baltzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel W A Baltzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6902,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.65852284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"5A","first_page":"2861","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.18459999561309814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokine-gene-therapy","display_name":"cytokine gene therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9210000038146973},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.8809999823570251},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-gamma-induction","display_name":"interferon-gamma induction","score":0.800000011920929},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/plasmid-transfection","display_name":"plasmid transfection","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7474991679191589},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6284488439559937},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6192972660064697},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5946105718612671},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5866010189056396},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5761333107948303},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.5164585113525391},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.498232364654541},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.48881933093070984},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4798423945903778},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45690053701400757},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.43138790130615234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39220088720321655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3741719126701355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22055351734161377},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21897652745246887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15517889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15517889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:50353905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15517889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W150745307","https://openalex.org/W1487549623","https://openalex.org/W1514942862","https://openalex.org/W1517678415","https://openalex.org/W1522816379","https://openalex.org/W1600694014","https://openalex.org/W1607695063","https://openalex.org/W1609710757","https://openalex.org/W1905805852","https://openalex.org/W1943387679","https://openalex.org/W1964977785","https://openalex.org/W1973632864","https://openalex.org/W1977817262","https://openalex.org/W1991524518","https://openalex.org/W1995127434","https://openalex.org/W2024418426","https://openalex.org/W2028688116","https://openalex.org/W2039109401","https://openalex.org/W2041748576","https://openalex.org/W2052895824","https://openalex.org/W2062346175","https://openalex.org/W2084538691","https://openalex.org/W2087905758","https://openalex.org/W2092768308","https://openalex.org/W2100510996","https://openalex.org/W2115310513","https://openalex.org/W2119969523","https://openalex.org/W2126263115","https://openalex.org/W2134472621","https://openalex.org/W2134768631","https://openalex.org/W2151707711","https://openalex.org/W2152098493","https://openalex.org/W2168115358","https://openalex.org/W2171831396","https://openalex.org/W4313308240","https://openalex.org/W4313310005"],"related_works":["https://openalex.org/W150745307","https://openalex.org/W1744949806","https://openalex.org/W6982021353","https://openalex.org/W2023367330","https://openalex.org/W4308397174","https://openalex.org/W3106917602","https://openalex.org/W1974802506","https://openalex.org/W2116435090","https://openalex.org/W2121744182","https://openalex.org/W2044629857"],"abstract_inverted_index":{"BACKGROUND:":[0],"Osteosarcomas":[1],"are":[2],"primary":[3],"malignant":[4],"tumors":[5],"of":[6,41,81,94,104,117,129,178],"bone":[7],"or":[8],"soft":[9],"parts":[10],"arising":[11],"from":[12],"bone-forming":[13],"mesenchymal":[14],"cells.":[15],"Despite":[16],"dramatic":[17],"therapeutic":[18],"advances,":[19],"namely":[20],"neo-adjuvant":[21],"and":[22,60,78,135,153,182],"adjuvant":[23,176],"chemotherapy,":[24],"progress":[25],"is":[26,67],"at":[27],"a":[28,35,126,171],"plateau.":[29],"Cytokine-mediated":[30],"gene":[31],"therapy":[32,40],"might":[33],"represent":[34],"further":[36],"advance":[37],"in":[38],"the":[39,42,75,140,158],"osteosarcoma.":[43],"MATERIALS":[44],"AND":[45],"METHODS:":[46],"We":[47],"transfected":[48,133],"UMR":[49,97],"108":[50,98],"osteosarcoma":[51],"cells":[52,99],"with":[53],"different":[54],"plasmids":[55],"encoding":[56],"IL-12,":[57],"IL-23,":[58],"proIL-18":[59],"ICE":[61],"(Interleukin-converting":[62],"enzyme).":[63],"IFN-gamma":[64,130,141,148,159,187],"induction,":[65],"which":[66,111],"known":[68],"to":[69,101,122,156,169],"induce":[70],"antitumor":[71],"effects":[72,80,106],"mediated":[73,107,143],"by":[74,96,108,114,144,164],"immune":[76],"system,":[77],"cytotoxic":[79,105],"various":[82],"cytokine":[83],"combination":[84],"were":[85,112],"investigated.":[86],"RESULTS:":[87],"Our":[88],"results":[89],"show":[90],"that":[91,161],"local":[92],"secretion":[93],"IL-12":[95,181],"led":[100],"an":[102],"induction":[103,131,142,149,188],"mononuclear":[109],"cells,":[110],"enhanced":[113,147],"additional":[115],"administration":[116],"recombinant":[118],"IL-18.":[119],"In":[120],"contrast":[121],"IL-18,":[123,183],"IL-23":[124,167],"showed":[125],"moderate":[127],"increase":[128,139,157],"when":[132,150,184],"alone":[134,152],"could":[136],"only":[137,186],"slightly":[138],"IL-12.":[145,165],"IL-18":[146],"applied":[151],"was":[154,162],"able":[155],"production":[160],"induced":[163],"CONCLUSION:":[166],"seems":[168],"be":[170],"less":[172],"effective":[173],"immuno-therapeutic":[174],"for":[175],"treatment":[177],"osteosarcomas":[179],"than":[180],"taking":[185],"into":[189],"consideration.":[190]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
