{"id":"https://openalex.org/W50329103","doi":"https://doi.org/10.1186/1472-6750-13-61","title":"Functional characterization of cinnamyl alcohol dehydrogenase and caffeic acid O-methyltransferase in Brachypodium distachyon","display_name":"Functional characterization of cinnamyl alcohol dehydrogenase and caffeic acid O-methyltransferase in Brachypodium distachyon","publication_year":2013,"publication_date":"2013-07-31","ids":{"openalex":"https://openalex.org/W50329103","doi":"https://doi.org/10.1186/1472-6750-13-61","mag":"50329103","pmid":"https://pubmed.ncbi.nlm.nih.gov/23902793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734214"},"language":"en","primary_location":{"id":"doi:10.1186/1472-6750-13-61","doi":"https://doi.org/10.1186/1472-6750-13-61","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6750-13-61","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/1472-6750-13-61","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/1472-6750-13-61","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082943427","display_name":"Gina M. Trabucco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina M Trabucco","raw_affiliation_strings":["Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082658630","display_name":"Dominick A. Matos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominick A Matos","raw_affiliation_strings":["Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA","Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101579780","display_name":"Scott Lee","orcid":"https://orcid.org/0000-0002-2913-3777","observed_orcids":["https://orcid.org/0000-0002-2913-3777"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J Lee","raw_affiliation_strings":["Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA","Plant Biology Graduate Program, University of Massachusetts, Amherst, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Plant Biology Graduate Program, University of Massachusetts, Amherst, MA, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071728493","display_name":"Aaron J. Saathoff","orcid":"https://orcid.org/0000-0001-8715-9978","observed_orcids":["https://orcid.org/0000-0001-8715-9978"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]},{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J Saathoff","raw_affiliation_strings":["USDA-ARS, Grain, Forage, and Bioenergy Research Unit, University of Nebraska-Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA-ARS, Grain, Forage, and Bioenergy Research Unit, University of Nebraska-Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901","https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059049622","display_name":"Henry D. Priest","orcid":"https://orcid.org/0000-0002-0998-8137","observed_orcids":["https://orcid.org/0000-0002-0998-8137"]},"institutions":[{"id":"https://openalex.org/I2799511691","display_name":"Donald Danforth Plant Science Center","ror":"https://ror.org/000cyem11","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799511691"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry D Priest","raw_affiliation_strings":["The Donald Danforth Plant Science Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Donald Danforth Plant Science Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I2799511691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044815595","display_name":"Todd C. Mockler","orcid":"https://orcid.org/0000-0002-0462-5775","observed_orcids":["https://orcid.org/0000-0002-0462-5775"]},"institutions":[{"id":"https://openalex.org/I2799511691","display_name":"Donald Danforth Plant Science Center","ror":"https://ror.org/000cyem11","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799511691"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd C Mockler","raw_affiliation_strings":["The Donald Danforth Plant Science Center, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Donald Danforth Plant Science Center, St. Louis, MO, USA","institution_ids":["https://openalex.org/I2799511691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000768953","display_name":"Gautam Sarath","orcid":"https://orcid.org/0000-0002-3145-9493","observed_orcids":["https://orcid.org/0000-0002-3145-9493"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]},{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gautam Sarath","raw_affiliation_strings":["USDA-ARS, Grain, Forage, and Bioenergy Research Unit, University of Nebraska-Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA-ARS, Grain, Forage, and Bioenergy Research Unit, University of Nebraska-Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901","https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089920583","display_name":"Samuel P. Hazen","orcid":"https://orcid.org/0000-0001-9131-8994","observed_orcids":["https://orcid.org/0000-0001-9131-8994"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel P Hazen","raw_affiliation_strings":["Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of Massachusetts 221 Morrill Science Center III, Amherst, MA, 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5089920583"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00279643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"1","first_page":"61","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cinnamyl-alcohol-dehydrogenase","display_name":"cinnamyl alcohol dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caffeic-acid-o-methyltransferase","display_name":"caffeic acid O-methyltransferase","score":0.996999979019165},{"id":"https://openalex.org/keywords/brachypodium-distachyon","display_name":"Brachypodium distachyon","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lignin-biosynthesis","display_name":"lignin biosynthesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lignin-modification","display_name":"lignin modification","score":0.5440000295639038},{"id":"https://openalex.org/keywords/syringyl-guaiacyl-ratio","display_name":"syringyl/guaiacyl ratio","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bioethanol-production","display_name":"bioethanol production","score":0.6510000228881836},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.5099999904632568},{"id":"https://openalex.org/keywords/flowering-time","display_name":"flowering time","score":0.5740000009536743},{"id":"https://openalex.org/keywords/stem-biomass","display_name":"stem biomass","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2777911459","wikidata":"https://www.wikidata.org/wiki/Q2352209","display_name":"Brachypodium distachyon","level":4,"score":0.904695987701416},{"id":"https://openalex.org/C2777749068","wikidata":"https://www.wikidata.org/wiki/Q157770","display_name":"Brachypodium","level":4,"score":0.6556545495986938},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.4972744286060333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4727547764778137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43650874495506287},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.06908532977104187},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018547","descriptor_name":"Plant Stems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018547","descriptor_name":"Plant Stems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D045868","descriptor_name":"Sorghum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058431","descriptor_name":"Brachypodium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D058431","descriptor_name":"Brachypodium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1472-6750-13-61","doi":"https://doi.org/10.1186/1472-6750-13-61","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6750-13-61","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/1472-6750-13-61","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2728109","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3734214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3734214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnol","raw_type":"Text"},{"id":"pmid:23902793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23902793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:works.bepress.com:samuel_hazen-1027","doi":null,"is_oa":false,"landing_page_url":"https://works.bepress.com/samuel_hazen/14","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Samuel P Hazen","raw_type":"text"},{"id":"mag:50329103","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/agronomyfacpub/687/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1472-6750-13-61","doi":"https://doi.org/10.1186/1472-6750-13-61","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6750-13-61","pdf_url":"https://bmcbiotechnol.biomedcentral.com/counter/pdf/10.1186/1472-6750-13-61","source":{"id":"https://openalex.org/S53489610","display_name":"BMC Biotechnology","issn_l":"1472-6750","issn":["1472-6750"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6735000014305115,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G222768804","display_name":null,"funder_award_id":"DE\u2010FG02\u2010","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W50329103.pdf","grobid_xml":"https://content.openalex.org/works/W50329103.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W238008956","https://openalex.org/W1273510369","https://openalex.org/W1481674534","https://openalex.org/W1506391974","https://openalex.org/W1521782672","https://openalex.org/W1549987037","https://openalex.org/W1580356584","https://openalex.org/W1598028551","https://openalex.org/W1972171731","https://openalex.org/W1975210341","https://openalex.org/W1979974711","https://openalex.org/W1980763040","https://openalex.org/W1998101208","https://openalex.org/W2002988274","https://openalex.org/W2009506727","https://openalex.org/W2011567004","https://openalex.org/W2013697149","https://openalex.org/W2014543358","https://openalex.org/W2016022129","https://openalex.org/W2019847443","https://openalex.org/W2020974916","https://openalex.org/W2023349042","https://openalex.org/W2028526344","https://openalex.org/W2035632664","https://openalex.org/W2039452276","https://openalex.org/W2040767957","https://openalex.org/W2040891760","https://openalex.org/W2044085217","https://openalex.org/W2045998325","https://openalex.org/W2055544560","https://openalex.org/W2056851667","https://openalex.org/W2057239399","https://openalex.org/W2058867396","https://openalex.org/W2059406847","https://openalex.org/W2059890422","https://openalex.org/W2060141033","https://openalex.org/W2064589531","https://openalex.org/W2064672862","https://openalex.org/W2071198352","https://openalex.org/W2072478286","https://openalex.org/W2077257346","https://openalex.org/W2086187764","https://openalex.org/W2091348851","https://openalex.org/W2104273276","https://openalex.org/W2106882534","https://openalex.org/W2106911146","https://openalex.org/W2113935469","https://openalex.org/W2117855730","https://openalex.org/W2117880514","https://openalex.org/W2119220115","https://openalex.org/W2120745885","https://openalex.org/W2127908346","https://openalex.org/W2127936231","https://openalex.org/W2128663241","https://openalex.org/W2130358932","https://openalex.org/W2130869997","https://openalex.org/W2131463690","https://openalex.org/W2132632499","https://openalex.org/W2140546650","https://openalex.org/W2142329758","https://openalex.org/W2142594546","https://openalex.org/W2145916464","https://openalex.org/W2147221916","https://openalex.org/W2147740905","https://openalex.org/W2149521176","https://openalex.org/W2150303148","https://openalex.org/W2151061998","https://openalex.org/W2152626489","https://openalex.org/W2155038677","https://openalex.org/W2155840061","https://openalex.org/W2157959147","https://openalex.org/W2158714788","https://openalex.org/W2165278495","https://openalex.org/W2167220491","https://openalex.org/W2167331806","https://openalex.org/W2175564726","https://openalex.org/W2413228664","https://openalex.org/W4234308538","https://openalex.org/W4235387963","https://openalex.org/W4250894847","https://openalex.org/W4256399090"],"related_works":["https://openalex.org/W42983302","https://openalex.org/W2005172971","https://openalex.org/W2145916464","https://openalex.org/W2080276314","https://openalex.org/W2077257346","https://openalex.org/W7009991554","https://openalex.org/W2039452276","https://openalex.org/W2142594546","https://openalex.org/W2009627793","https://openalex.org/W2206413993"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lignin":[1],"is":[2],"a":[3,121,135,157,175],"significant":[4],"barrier":[5],"in":[6,26,36,74,134,146,159,167,177,188,197,208,213,221],"the":[7,27,75,82,126,168,209],"conversion":[8],"of":[9,29,84,118,185],"plant":[10],"biomass":[11,224],"to":[12,100],"bioethanol.":[13],"Cinnamyl":[14],"alcohol":[15],"dehydrogenase":[16],"(CAD)":[17],"and":[18,39,58,64,71,111,115,149,154,163,181,226],"caffeic":[19],"acid":[20],"O-methyltransferase":[21],"(COMT)":[22],"catalyze":[23],"key":[24,206],"steps":[25],"pathway":[28,212],"lignin":[30,56,142,160,179,210],"monomer":[31],"biosynthesis.":[32],"Brown":[33],"midrib":[34,124],"mutants":[35],"Zea":[37],"mays":[38],"Sorghum":[40],"bicolor":[41],"with":[42,81],"impaired":[43],"CAD":[44,70],"or":[45,103],"COMT":[46,72],"activity":[47],"have":[48,203],"attracted":[49],"considerable":[50],"agronomic":[51],"interest":[52],"for":[53,87],"their":[54],"altered":[55,108],"composition":[57],"improved":[59],"digestibility.":[60],"Here,":[61],"we":[62],"identified":[63],"functionally":[65],"characterized":[66],"candidate":[67],"genes":[68,207],"encoding":[69],"enzymes":[73],"grass":[76],"model":[77],"species":[78],"Brachypodium":[79],"distachyon":[80,215],"aim":[83],"improving":[85],"crops":[86],"efficient":[88],"biofuel":[89],"production.":[90],"RESULTS:":[91],"We":[92],"developed":[93],"transgenic":[94,169],"plants":[95,173],"overexpressing":[96],"artificial":[97],"microRNA":[98],"designed":[99],"silence":[101],"BdCAD1":[102,119,147],"BdCOMT4.":[104],"Both":[105],"transgenes":[106],"caused":[107,120],"flowering":[109],"time":[110,128],"increased":[112],"stem":[113,223],"count":[114],"weight.":[116],"Downregulation":[117],"leaf":[122],"brown":[123],"phenotype,":[125],"first":[127],"this":[129],"phenotype":[130],"has":[131],"been":[132],"observed":[133],"C3":[136],"plant.":[137],"While":[138],"acetyl":[139],"bromide":[140],"soluble":[141],"measurements":[143],"were":[144],"equivalent":[145],"downregulated":[148,172],"control":[150],"plants,":[151],"histochemical":[152],"staining":[153,184],"thioacidolysis":[155],"indicated":[156],"decrease":[158],"syringyl":[161,186],"units":[162,187],"reduced":[164],"syringyl/guaiacyl":[165],"ratio":[166],"plants.":[170,199],"BdCOMT4":[171],"exhibited":[174],"reduction":[176],"total":[178],"content":[180],"decreased":[182],"Maule":[183],"stem.":[189],"Ethanol":[190],"yield":[191,225],"by":[192],"microbial":[193],"fermentation":[194],"was":[195],"enhanced":[196],"amiR-cad1-8":[198],"CONCLUSION:":[200],"These":[201],"results":[202],"elucidated":[204],"two":[205],"biosynthetic":[211],"B.":[214],"that,":[216],"when":[217],"perturbed,":[218],"may":[219],"result":[220],"greater":[222],"bioconversion":[227],"efficiency.":[228]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}