{"id":"https://openalex.org/W50296391","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","title":"Abstract 1889: Cardiac Resynchronization Therapy With Biventricular Pacing Improves Renal Function in Heart Failure Patients With Reduced Glomerular Filtration Rate","display_name":"Abstract 1889: Cardiac Resynchronization Therapy With Biventricular Pacing Improves Renal Function in Heart Failure Patients With Reduced Glomerular Filtration Rate","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W50296391","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","mag":"50296391"},"language":"en","primary_location":{"id":"doi:10.1161/circ.116.suppl_16.ii_405-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049262407","display_name":"Guido Boerrigter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Boerrigter","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064435807","display_name":"Lisa C. Costello\u2010Boerrigter","orcid":"https://orcid.org/0000-0002-6534-1629","observed_orcids":["https://orcid.org/0000-0002-6534-1629"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa C Costello-Boerrigter","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066384461","display_name":"William T. Abraham","orcid":"https://orcid.org/0000-0003-4805-1037","observed_orcids":["https://orcid.org/0000-0003-4805-1037"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T Abraham","raw_affiliation_strings":["Ohio State Univ Heart Cntr, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ Heart Cntr, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113543553","display_name":"Martin G. St. John Sutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin G St. John Sutton","raw_affiliation_strings":["Univ of Pennsylvania Med Cntr, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania Med Cntr, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048111190","display_name":"Denise M. Heublein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise M Heublein","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040952017","display_name":"Kristin M. Kruger","orcid":"https://orcid.org/0009-0002-1999-0991","observed_orcids":["https://orcid.org/0009-0002-1999-0991"]},"institutions":[{"id":"https://openalex.org/I4210091810","display_name":"Medtronic (United States)","ror":"https://ror.org/00grd1h17","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin M Kruger","raw_affiliation_strings":["Medtronic, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medtronic, Minneapolis, MN","institution_ids":["https://openalex.org/I4210091810"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael R Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091810","display_name":"Medtronic (United States)","ror":"https://ror.org/00grd1h17","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R Hill","raw_affiliation_strings":["Medtronic, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medtronic, Minneapolis, MN","institution_ids":["https://openalex.org/I4210091810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008382551","display_name":"Peter Andrew McCullough","orcid":"https://orcid.org/0000-0002-0997-6355","observed_orcids":["https://orcid.org/0000-0002-0997-6355"]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A McCullough","raw_affiliation_strings":["William Beaumont Hosp, Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Beaumont Hosp, Royal Oak, MI","institution_ids":["https://openalex.org/I2799370151","https://openalex.org/I4210128757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101494602","display_name":"John C. Jr Burnett","orcid":"https://orcid.org/0000-0002-3414-1659","observed_orcids":["https://orcid.org/0000-0002-3414-1659"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C Burnett","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"suppl_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8629999756813049},{"id":"https://openalex.org/keywords/reduced-glomerular-filtration-rate","display_name":"reduced glomerular filtration rate","score":0.9179999828338623},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neurohormonal-activation","display_name":"neurohormonal activation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.8140000104904175},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.6690000295639038},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ventricular-dyssynchrony","display_name":"ventricular dyssynchrony","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9523876905441284},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.8286148309707642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7688515186309814},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7681859731674194},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7651135921478271},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7647494077682495},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6936737895011902},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.46619004011154175},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4432624280452728},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4285811185836792},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.4118277132511139},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.16818225383758545}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.116.suppl_16.ii_405-a","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_405-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029289523","https://openalex.org/W2095491035","https://openalex.org/W1967040999","https://openalex.org/W2601217873","https://openalex.org/W2131418980","https://openalex.org/W1481516130","https://openalex.org/W2389113411","https://openalex.org/W2156960995","https://openalex.org/W2790439805","https://openalex.org/W2037517320"],"abstract_inverted_index":{"Background:":[0],"Renal":[1],"dysfunction":[2],"has":[3],"emerged":[4],"as":[5,45],"an":[6],"important":[7],"independent":[8],"prognostic":[9],"factor":[10],"in":[11,29,53,76,136,143,146,178,195,208,225,235,243,281],"patients":[12,31,54,78,283],"with":[13,32,55,79,141,156,223,228,241,260,284],"heart":[14],"failure":[15],"(HF).":[16],"Cardiac":[17],"resynchronization":[18],"therapy":[19],"(CRT)":[20],"improves":[21],"functional":[22],"status":[23],"and":[24,89,98,126,163,171,175,186,202,220,252,268,276,304],"left":[25],"ventricular":[26,33],"(LV)":[27],"function":[28],"HF":[30,77,282],"dyssynchrony.":[34],"We":[35],"hypothesized":[36],"that":[37],"CRT":[38,75,110,166,182,224,273,292],"would":[39],"also":[40,139],"improve":[41,295],"glomerular":[42],"filtration":[43],"rate":[44],"estimated":[46],"by":[47],"the":[48,65,299,309],"abbreviated":[49],"MDRD":[50],"equation":[51],"(eGFR)":[52],"reduced":[56,152,187,217,261,277,285],"eGFR.":[57,230,287],"Methods:":[58],"This":[59],"is":[60],"a":[61,257],"retrospective":[62],"analysis":[63],"of":[64,301,312],"Multicenter":[66],"InSync":[67],"Randomized":[68],"Clinical":[69],"Evaluation":[70],"(MIRACLE)":[71],"study,":[72],"which":[73],"evaluated":[74,95],"NYHA":[80],"class":[81],"III\u2013IV,":[82],"ejection":[83,169],"fraction":[84,170],"\u226435%,":[85],"QRS":[86],"\u2265130":[87],"ms,":[88],"stable":[90],"medical":[91],"regimen.":[92],"Patients":[93,112],"were":[94,113,138],"before":[96],"implantation":[97],"6":[99],"months":[100],"after":[101],"randomization":[102],"to":[103,116,193,265],"control":[104,194],"(CRT":[105],"device":[106],"OFF,":[107],"n=225)":[108],"or":[109],"(n=228).":[111],"categorized":[114],"according":[115],"their":[117],"baseline":[118,286],"eGFR:":[119],"\u226590":[120],"(category":[121,124,128],"A),":[122],"60\u2264eGFR<90":[123],"B),":[125],"30\u2264eGFR<60":[127],"C)":[129],"mL/min":[130],"per":[131],"1.73m":[132],"2":[133],".":[134],"Changes":[135],"eGFR":[137,153,184,236,275],"correlated":[140,237],"changes":[142,234,242],"other":[144],"parameters":[145],"univariate":[147,232],"analysis.":[148],"Results:":[149],"At":[150],"baseline,":[151],"was":[154],"associated":[155],"ischemic":[157],"etiology,":[158],"increased":[159,167,266,274],"age,":[160],"mitral":[161,176],"regurgitation,":[162],"neurohumoral":[164,262],"activation.":[165],"LV":[168,173],"decreased":[172],"volumes":[174],"regurgitation":[177],"all":[179],"categories.":[180],"Importantly,":[181],"improved":[183],"(p=0.003)":[185],"blood":[188,254,278],"urea":[189,279],"nitrogen":[190,280],"(p=0.008)":[191],"compared":[192],"category":[196,209],"C,":[197],"but":[198,239],"not":[199],"A":[200],"(p=0.75/p=0.41)":[201],"B":[203],"(p=0.43/p=0.89).":[204],"In":[205,231],"addition,":[206],"only":[207],"C":[210],"did":[211],"atrial":[212,218],"natriuretic":[213],"peptide":[214],"decrease,":[215],"suggesting":[216],"distention":[219],"filling":[221],"pressures":[222],"this":[226],"group":[227],"impaired":[229],"analysis,":[233],"weakly":[238],"significantly":[240],"aldosterone":[244],"(r=\u22120.22),":[245],"plasma":[246],"renin":[247],"activity":[248],"(r=\u22120.19,":[249],"norepinephrine":[250],"(r=\u22120.16),":[251],"mean":[253],"pressure":[255],"(r=+0.14),":[256],"pattern":[258],"consistent":[259],"activation":[263],"due":[264],"systemic":[267],"renal":[269,296],"perfusion":[270],"pressure.":[271],"Conclusions:":[272],"By":[288],"improving":[289],"cardiac":[290],"function,":[291,297],"can":[293],"indirectly":[294],"underscoring":[298],"importance":[300],"cardiorenal":[302],"interaction":[303],"providing":[305],"another":[306],"mechanism":[307],"for":[308],"beneficial":[310],"effects":[311],"CRT.":[313]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
