{"id":"https://openalex.org/W50238742","doi":null,"title":"Incorporation of bacterial quorum sensing in synthetic biology","display_name":"Incorporation of bacterial quorum sensing in synthetic biology","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W50238742","mag":"50238742"},"language":"en","primary_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/12779","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/12779","pdf_url":"http://hdl.handle.net/1903/12779","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1903/12779","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061432062","display_name":"Hsuan\u2010Chen Wu","orcid":"https://orcid.org/0000-0002-7837-1333","observed_orcids":["https://orcid.org/0000-0002-7837-1333"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hsuan\u2010Chen Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7837-1333","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061432062"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.16689999401569366,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-quorum-sensing","display_name":"bacterial quorum sensing","score":0.921999990940094},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.7870000004768372},{"id":"https://openalex.org/keywords/egfr-targeting","display_name":"EGFR targeting","score":0.515999972820282},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.5080000162124634},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7509999871253967},{"id":"https://openalex.org/keywords/rna-based-drug-delivery","display_name":"RNA-based drug delivery","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cell-cycle-inhibition","display_name":"cell cycle inhibition","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.3919999897480011},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.3970000147819519},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.328000009059906},{"id":"https://openalex.org/keywords/biological-switches","display_name":"biological switches","score":0.3490000069141388},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.859256386756897},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6300842761993408},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6051301956176758},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5855451226234436},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5317835807800293},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.45623019337654114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4152989685535431},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3860774040222168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35525748133659363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33507370948791504},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2510334253311157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20011642575263977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13757896423339844},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13650751113891602}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:drum.lib.umd.edu:1903/12779","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/12779","pdf_url":"http://hdl.handle.net/1903/12779","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:50238742","doi":null,"is_oa":false,"landing_page_url":"https://drum.lib.umd.edu/bitstream/1903/12779/1/Wu_umd_0117E_13096.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/12779","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/12779","pdf_url":"http://hdl.handle.net/1903/12779","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W50238742.pdf","grobid_xml":"https://content.openalex.org/works/W50238742.grobid-xml"},"referenced_works_count":133,"referenced_works":["https://openalex.org/W71254526","https://openalex.org/W144209598","https://openalex.org/W152438524","https://openalex.org/W203925562","https://openalex.org/W1518494853","https://openalex.org/W1555714030","https://openalex.org/W1568786750","https://openalex.org/W1600101017","https://openalex.org/W1647075334","https://openalex.org/W1945505508","https://openalex.org/W1965688652","https://openalex.org/W1967117869","https://openalex.org/W1968547128","https://openalex.org/W1969541360","https://openalex.org/W1970109685","https://openalex.org/W1970139226","https://openalex.org/W1970632704","https://openalex.org/W1970762019","https://openalex.org/W1970768185","https://openalex.org/W1971042394","https://openalex.org/W1974482866","https://openalex.org/W1978119727","https://openalex.org/W1979507175","https://openalex.org/W1979579658","https://openalex.org/W1984247855","https://openalex.org/W1984899070","https://openalex.org/W1985193442","https://openalex.org/W1986373434","https://openalex.org/W1993516105","https://openalex.org/W1993707958","https://openalex.org/W1998490971","https://openalex.org/W2000004958","https://openalex.org/W2000796780","https://openalex.org/W2002216556","https://openalex.org/W2003209357","https://openalex.org/W2003744056","https://openalex.org/W2004916914","https://openalex.org/W2006906242","https://openalex.org/W2007769474","https://openalex.org/W2009197921","https://openalex.org/W2010072735","https://openalex.org/W2011742016","https://openalex.org/W2012893444","https://openalex.org/W2014486365","https://openalex.org/W2015270686","https://openalex.org/W2017348361","https://openalex.org/W2018729653","https://openalex.org/W2019462587","https://openalex.org/W2019662066","https://openalex.org/W2021099440","https://openalex.org/W2021505095","https://openalex.org/W2023083220","https://openalex.org/W2024314601","https://openalex.org/W2024600401","https://openalex.org/W2025692302","https://openalex.org/W2025971310","https://openalex.org/W2026197731","https://openalex.org/W2031149444","https://openalex.org/W2031866247","https://openalex.org/W2032515207","https://openalex.org/W2033950216","https://openalex.org/W2036228067","https://openalex.org/W2036515665","https://openalex.org/W2037376666","https://openalex.org/W2037550429","https://openalex.org/W2042352676","https://openalex.org/W2043711091","https://openalex.org/W2045609136","https://openalex.org/W2046707498","https://openalex.org/W2048955235","https://openalex.org/W2049675426","https://openalex.org/W2056333932","https://openalex.org/W2057993765","https://openalex.org/W2063787809","https://openalex.org/W2065858300","https://openalex.org/W2066444032","https://openalex.org/W2066614304","https://openalex.org/W2068865578","https://openalex.org/W2076705784","https://openalex.org/W2077374889","https://openalex.org/W2077515954","https://openalex.org/W2080237747","https://openalex.org/W2081182500","https://openalex.org/W2081568682","https://openalex.org/W2083440297","https://openalex.org/W2086758328","https://openalex.org/W2087966138","https://openalex.org/W2090115060","https://openalex.org/W2093343938","https://openalex.org/W2093410766","https://openalex.org/W2094943792","https://openalex.org/W2098370603","https://openalex.org/W2098586552","https://openalex.org/W2101807260","https://openalex.org/W2103359264","https://openalex.org/W2104941420","https://openalex.org/W2106130060","https://openalex.org/W2110286022","https://openalex.org/W2111395371","https://openalex.org/W2114228460","https://openalex.org/W2116137883","https://openalex.org/W2117986752","https://openalex.org/W2118540273","https://openalex.org/W2123630861","https://openalex.org/W2126922170","https://openalex.org/W2127626778","https://openalex.org/W2128609649","https://openalex.org/W2129695021","https://openalex.org/W2131722151","https://openalex.org/W2131869707","https://openalex.org/W2133567026","https://openalex.org/W2136246490","https://openalex.org/W2142231730","https://openalex.org/W2143337671","https://openalex.org/W2144588155","https://openalex.org/W2147203051","https://openalex.org/W2147516046","https://openalex.org/W2147926680","https://openalex.org/W2149526286","https://openalex.org/W2149871164","https://openalex.org/W2149879897","https://openalex.org/W2149953110","https://openalex.org/W2150036831","https://openalex.org/W2155739362","https://openalex.org/W2157642984","https://openalex.org/W2157815481","https://openalex.org/W2160133892","https://openalex.org/W2160237938","https://openalex.org/W2167215594","https://openalex.org/W2170270887","https://openalex.org/W2171757104","https://openalex.org/W2172162088","https://openalex.org/W2482467274"],"related_works":["https://openalex.org/W2025607954","https://openalex.org/W2023281014","https://openalex.org/W2123630861","https://openalex.org/W2008269785","https://openalex.org/W3196698463","https://openalex.org/W1813974341","https://openalex.org/W4200366546","https://openalex.org/W2298187136","https://openalex.org/W7222529758","https://openalex.org/W3120042641"],"abstract_inverted_index":{"The":[0],"global":[1],"objective":[2],"of":[3,14,140,163,182,186,201,239,256,300,350,381,404,423,436,452,466],"this":[4,141,164,343,428],"research":[5],"is":[6,417,462],"to":[7,52,64,73,87,100,151,168,275,296,311,321,362,457],"develop":[8],"a":[9,56,92,117,134,202,211,257,340,402,412,424,458],"synthetic":[10,358,437,453],"biology":[11,359],"toolkit":[12],"consisting":[13],"molecules,":[15],"cells,":[16,126],"and":[17,26,61,82,97,161,177,227,232,315,325,354,392,398,434],"devices":[18,387],"that":[19,29,49,191,205,309,331,388,395,416,444],"provide":[20],"flexible,":[21],"yet":[22],"selective":[23],"targeting,":[24],"sensing,":[25],"switching":[27,83,178],"capabilities,":[28],"in":[30,35,133,220,262,285,335,367],"turn":[31],"guide":[32,312],"biological":[33,203,414],"behavior":[34],"user-specified":[36],"manner.":[37],"We":[38,45,157,409],"employ":[39],"bacteria":[40,48,86],"as":[41,384,455],"\"smart\"":[42],"programmable":[43,385],"devices.":[44],"envision":[46,378,411],"creating":[47],"autonomously":[50],"move":[51,62],"specific":[53,76,173],"areas,":[54],"synthesize":[55],"drug,":[57,60],"deliver":[58,393],"the":[59,71,138,159,183,199,236,298,301,346,379,420,432,442,445,450,463],"on":[63,105,116,123,235,244,270,419],"new":[65,413],"sites.":[66],"\"Targeting\"":[67],"endows":[68],"bacterial":[69,130,187,254,271,382],"cells":[70,131,383],"means":[72],"dock":[74,391],"onto":[75],"surfaces":[77,170],"with":[78,155,172],"antibody-antigen":[79],"specificity.":[80],"Sensing":[81],"capability":[84],"allows":[85],"sense":[88],"and,":[89],"after":[90,210,401],"making":[91],"\"decision\",":[93],"respond":[94],"by":[95,166,305],"synthesizing":[96],"delivering":[98],"cargo":[99],"molecular":[101,258,425],"scale":[102],"features":[103,110],"displayed":[104,243],"target":[106],"surfaces.":[107],"Relevant":[108],"surface":[109,237],"may":[111,448],"include":[112],"an":[113,145,368],"overexpressed":[114],"receptor":[115,122],"tumor":[118],"cell,":[119],"glucagon-like":[120],"peptide-1":[121],"pancreatic":[124],"beta":[125],"or":[127,260,267],"even":[128],"other":[129],"resident":[132],"recalcitrant":[135],"biofilm.":[136],"Towards":[137],"realization":[139],"goal,":[142],"we":[143,179,197,225,273,290,377],"employed":[144],"antibody-binding":[146],"protein":[147,365],"G":[148],"display":[149],"strategy":[150,319],"complex":[152,165],"target-binding":[153],"antibodies":[154],"bacteria.":[156],"characterized":[158],"assembly":[160],"efficacy":[162],"binding":[167],"well-defined":[169],"decorated":[171],"antigens.":[174],"For":[175],"sensing":[176,189,231],"made":[180],"use":[181,284],"genetic":[184],"circuitry":[185],"quorum":[188],"(QS)":[190],"coordinates":[192],"multicellular":[193],"responses.":[194],"In":[195,375],"particular,":[196],"hypothesized":[198],"creation":[200],"\"switch\"":[204,415],"would":[206],"take":[207],"action":[208],"only":[209,400],"certain":[212],"threshold":[213],"\"feature\"":[214],"density":[215,238,422],"had":[216],"been":[217],"detected.":[218],"Specifically,":[219],"our":[221,318],"most":[222],"significant":[223],"demonstration":[224],"designed":[226,291],"implemented":[228],"QS":[229],"based":[230,234,418],"actuating":[233],"cancer-indicating":[240],"EGFR":[241],"receptors":[242],"epithelial":[245],"cancer":[246,286],"cell":[247,303,313,323,327,351,355,373,447],"lines.":[248],"Because":[249],"recent":[250],"reports":[251],"have":[252],"demonstrated":[253],"placement":[255],"\"cargo\"":[259],"\"payload\"":[261],"unrelated":[263],"studies":[264],"involving":[265],"vaccination":[266],"direct":[268],"attack":[269],"pathogens,":[272],"turned":[274],"developing":[276],"innovative":[277],"RNA-based":[278],"drug":[279],"syntheses":[280],"concepts":[281,440],"for":[282],"eventual":[283],"therapy.":[287],"That":[288],"is,":[289],"RNA":[292],"interfering":[293],"(RNAi)":[294],"technology":[295],"arrest":[297],"progression":[299],"eukaryotic":[302,371],"cycle":[304,352],"silencing":[306],"gateway":[307],"genes":[308],"serve":[310,361],"division":[314],"proliferation.":[316],"Thus,":[317],"serves":[320],"inhibit":[322],"growth":[324,356],"promote":[326,363],"death":[328],"-":[329,427],"actions":[330],"could":[332],"find":[333],"utility":[334],"treating":[336],"metastatic":[337],"cancer.":[338],"Through":[339],"different":[341],"lens,":[342],"same":[344],"concept,":[345],"molecularly":[347],"\"programmed\"":[348],"manipulation":[349],"status":[353],"via":[357],"can":[360,389],"recombinant":[364],"production":[366],"industrially":[369],"relevant":[370],"insect":[372],"line.":[374],"summary,":[376],"exploitation":[380],"smart":[386],"target,":[390],"cargoes":[394],"are":[396,407],"synthesized":[397,459],"delivered":[399],"set":[403],"predetermined":[405],"parameters":[406],"met.":[408],"also":[410],"area-based":[421],"feature":[426],"will":[429],"dramatically":[430],"expand":[431],"capabilities":[433],"reach":[435],"biology.":[438],"Our":[439],"embrace":[441],"notion":[443],"individual":[446],"be":[449],"product":[451,465],"biology,":[454],"opposed":[456],"molecule":[460],"which":[461],"prevailing":[464],"choice.":[467]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
