{"id":"https://openalex.org/W50217149","doi":null,"title":"An optimized colony forming assay for low-dose- radiation cell survival measurement","display_name":"An optimized colony forming assay for low-dose- radiation cell survival measurement","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W50217149","mag":"50217149"},"language":"en","primary_location":{"id":"mag:50217149","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Nan_Ding4/publication/241910032_An_optimized_colony_forming_assay_for_low-dose-radiation_cell_survival_measurement/links/004635302a46143ee7000000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210213804","display_name":"International Research Journal of Biotechnology","issn_l":"2141-5153","issn":["2141-5153"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Research Journal of Biotechnology","raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W50217149"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101658268","display_name":"Jinhan Zhu","orcid":"https://orcid.org/0000-0002-5011-196X","observed_orcids":["https://orcid.org/0000-0002-5011-196X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinhan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079110185","display_name":"Betsy M. Sutherland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betsy M. Sutherland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015294175","display_name":"Wenli Hu","orcid":"https://orcid.org/0000-0002-4127-1929","observed_orcids":["https://orcid.org/0000-0002-4127-1929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenli Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4127-1929","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011778","display_name":"Nan Ding","orcid":"https://orcid.org/0000-0002-4977-4344","observed_orcids":["https://orcid.org/0000-0002-4977-4344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Ding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4977-4344","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110734892","display_name":"C Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010158569","display_name":"M. R. Usikalu","orcid":"https://orcid.org/0000-0003-2233-4055","observed_orcids":["https://orcid.org/0000-0003-2233-4055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. R. Usikalu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2233-4055","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415930","display_name":"S. Li","orcid":"https://orcid.org/0000-0002-7796-0662","observed_orcids":["https://orcid.org/0000-0002-7796-0662"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210131271","display_name":"Institute of Modern Physics","ror":"https://ror.org/03x8rhq63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210131271"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Li","raw_affiliation_strings":["Institute of Modern Physics, Chinese Academy of Sciences,"],"raw_orcid":"https://orcid.org/0000-0002-7796-0662","affiliations":[{"raw_affiliation_string":"Institute of Modern Physics, Chinese Academy of Sciences,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210131271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101460086","display_name":"Burong Hu","orcid":"https://orcid.org/0000-0003-0156-9154","observed_orcids":["https://orcid.org/0000-0003-0156-9154"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210131271","display_name":"Institute of Modern Physics","ror":"https://ror.org/03x8rhq63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210131271"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Burong Hu","raw_affiliation_strings":["Institute of Modern Physics, Chinese Academy of Sciences,"],"raw_orcid":"https://orcid.org/0000-0003-0156-9154","affiliations":[{"raw_affiliation_string":"Institute of Modern Physics, Chinese Academy of Sciences,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210131271"]}]},{"author_position":"last","author":{"id":null,"display_name":"Guangmin Zhou","orcid":"https://orcid.org/0000-0002-3629-5686","observed_orcids":["https://orcid.org/0000-0002-3629-5686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangmin Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3629-5686","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2115,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5533221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.9350000023841858},{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7850000262260437},{"id":"https://openalex.org/keywords/x-ray-irradiation","display_name":"X-ray irradiation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/plating-efficiency","display_name":"plating efficiency","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.6100000143051147},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.847000002861023},{"id":"https://openalex.org/keywords/glioma-cell-lines","display_name":"glioma cell lines","score":0.8389999866485596},{"id":"https://openalex.org/keywords/survival-fraction","display_name":"survival fraction","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776127477","wikidata":"https://www.wikidata.org/wiki/Q17093220","display_name":"Plating efficiency","level":3,"score":0.8178734183311462},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.7140541076660156},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6883086562156677},{"id":"https://openalex.org/C2776985018","wikidata":"https://www.wikidata.org/wiki/Q7202314","display_name":"Plating (geology)","level":2,"score":0.650851845741272},{"id":"https://openalex.org/C2583947","wikidata":"https://www.wikidata.org/wiki/Q5058179","display_name":"Cell counting","level":4,"score":0.5715356469154358},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5236544609069824},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.522749662399292},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.492622435092926},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.47896745800971985},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46121490001678467},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3435952663421631},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.33473852276802063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.311014324426651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.267425000667572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15097400546073914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1139712929725647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0797111988067627},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:50217149","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Nan_Ding4/publication/241910032_An_optimized_colony_forming_assay_for_low-dose-radiation_cell_survival_measurement/links/004635302a46143ee7000000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210213804","display_name":"International Research Journal of Biotechnology","issn_l":"2141-5153","issn":["2141-5153"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Research Journal of Biotechnology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1967119618","https://openalex.org/W1975664090","https://openalex.org/W1976400042","https://openalex.org/W1982227729","https://openalex.org/W1993765233","https://openalex.org/W2005191632","https://openalex.org/W2009015836","https://openalex.org/W2026382290","https://openalex.org/W2072153851","https://openalex.org/W2080434562","https://openalex.org/W2086031816","https://openalex.org/W2086535041","https://openalex.org/W2099888675","https://openalex.org/W2109126550","https://openalex.org/W2150370833","https://openalex.org/W2151259214","https://openalex.org/W2152414287","https://openalex.org/W2162873935"],"related_works":["https://openalex.org/W2292546446","https://openalex.org/W1987957856","https://openalex.org/W2024396314","https://openalex.org/W4290659617","https://openalex.org/W2003421354","https://openalex.org/W2341349504","https://openalex.org/W1981627449","https://openalex.org/W2203768080","https://openalex.org/W2014533486","https://openalex.org/W2373193996"],"abstract_inverted_index":{"The":[0,110],"aim":[1],"of":[2,18,29,65,87,94,108,116,137,146,185],"this":[3],"study":[4],"is":[5],"to":[6,13,105,119,131,180,189],"develop":[7],"a":[8,68,114,175],"simple":[9,178],"and":[10,35,42,58,89,99,135,149,159,177],"reliable":[11,176],"method":[12],"quantify":[14],"the":[15,26,45,63,79,85,92,100,133,143,156,182,198],"cell":[16,40,49,96,152,167],"survival":[17,144,183],"low-dose":[19,201],"irradiations.":[20],"Two":[21],"crucial":[22],"factors":[23],"were":[24],"considered,":[25],"same":[27],"number":[28],"cells":[30,54,61,83,187],"plated":[31,82],"in":[32,55,67],"each":[33],"flask":[34],"an":[36],"appropriate":[37],"interval":[38],"between":[39],"plating":[41,74,101,123],"irradiation.":[43,72],"For":[44,78],"former,":[46],"we":[47,81,140,172],"optimized":[48,157],"harvest":[50],"with":[51,166],"trypsin,":[52],"diluted":[53],"one":[56],"container,":[57],"directly":[59],"seeded":[60],"on":[62,84,200],"bottom":[64,86],"flasks":[66,88],"low":[69,190],"density":[70],"before":[71],"Reproducible":[73],"efficiency":[75,102],"was":[76,124],"obtained.":[77],"latter,":[80],"then":[90],"monitored":[91],"processing":[93],"attachment,":[95],"cycle":[97],"variations,":[98],"after":[103,122],"exposure":[104],"20":[106],"cGy":[107],"X-rays.":[109],"results":[111,162],"showed":[112],"that":[113],"period":[115],"4.5":[117],"h":[118,121],"7.5":[120],"suitable":[125],"for":[126,197],"further":[127],"treatment.":[128],"In":[129,170],"order":[130],"confirm":[132],"reliability":[134],"feasibility":[136],"our":[138],"method,":[139],"also":[141],"measured":[142],"curves":[145],"these":[147],"M059K":[148],"M059J":[150],"glioma":[151],"lines":[153],"by":[154,164],"following":[155],"protocol":[158],"obtained":[160],"consistent":[161],"reported":[163],"others":[165],"sorting":[168],"system.":[169],"conclusion,":[171],"successfully":[173],"developed":[174],"way":[179],"measure":[181],"fractions":[184],"human":[186],"exposed":[188],"dose":[191],"irradiation,":[192],"which":[193],"might":[194],"be":[195],"helpful":[196],"studiesmore\u00a0\u00bb":[199],"radiation":[202],"biology.\u00ab\u00a0less":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}