{"id":"https://openalex.org/W5000092","doi":null,"title":"[Leukemia and pre-leukemic conditions occurring after treatment of breast cancer].","display_name":"[Leukemia and pre-leukemic conditions occurring after treatment of breast cancer].","publication_year":2000,"publication_date":"2000-01-29","ids":{"openalex":"https://openalex.org/W5000092","mag":"5000092","pmid":"https://pubmed.ncbi.nlm.nih.gov/10686962"},"language":"fr","primary_location":{"id":"pmid:10686962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10686962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Presse medicale (Paris, France : 1983)","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070666254","display_name":"B. Cutuli","orcid":"https://orcid.org/0000-0002-8319-6429","observed_orcids":["https://orcid.org/0000-0002-8319-6429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Cutuli","raw_affiliation_strings":["Centre de Radioth\u00e9rapie et d'Oncologie M\u00e9dicale, Clinique de Courlancy, Reims"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Radioth\u00e9rapie et d'Oncologie M\u00e9dicale, Clinique de Courlancy, Reims","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108999501","display_name":"M Janvier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Janvier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746344","display_name":"Anne de la Rochefordi\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A de la Rochefordi\u00e8re","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110140265","display_name":"J.P. Julien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Julien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082347575","display_name":"Nicol\u00e1s Isambert","orcid":"https://orcid.org/0000-0003-3596-2114","observed_orcids":["https://orcid.org/0000-0003-3596-2114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Isambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Alzieu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Alzieu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080896131","display_name":"Pierre Kerbrat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Kerbrat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069526529","display_name":"Brigitte de Lafontan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B de Lafontan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086758937","display_name":"L van Lemmens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L van Lemmens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046469470","display_name":"H. Cur\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Cur\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G Ganem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Ganem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015114299","display_name":"Daniel M. Baume","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Baume","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108406359","display_name":"A. Le Mevel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Le Mevel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081906810","display_name":"A Lorthoraly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lorthoraly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055742754","display_name":"C. De Gislain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C de Gislain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109966601","display_name":"C. Marchal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Marchal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018706961","display_name":"C. Chevelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Chevelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Lauche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Lauche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113285418","display_name":"D. Serin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Serin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6709,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67648823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"3","first_page":"135","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-leukemia","display_name":"secondary leukemia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chemotherapy-induced-leukemia","display_name":"chemotherapy-induced leukemia","score":0.527999997138977},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.8169999718666077},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/mastectomy","display_name":"mastectomy","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9428567886352539},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6796180009841919},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6729736328125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6436981558799744},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5878370404243469},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5363532304763794},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5294708013534546},{"id":"https://openalex.org/C2779378344","wikidata":"https://www.wikidata.org/wiki/Q264118","display_name":"Acute myeloblastic leukemia","level":3,"score":0.5096862316131592},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5023901462554932},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.4669341444969177},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37114110589027405}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011289","descriptor_name":"Preleukemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10686962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10686962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Presse medicale (Paris, France : 1983)","raw_type":"Clinical Trial"},{"id":"mag:5000092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10686962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115340229","https://openalex.org/W1844816815","https://openalex.org/W2039998957","https://openalex.org/W2123601098","https://openalex.org/W2060271466","https://openalex.org/W2080420746","https://openalex.org/W1654581501","https://openalex.org/W2050760756","https://openalex.org/W2294557545","https://openalex.org/W2000417780"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,87,171],"purpose":[2],"of":[3,14,22,29,41,89,91,147,173,176,188,193,197,205,222,228],"this":[4],"study":[5,243],"was":[6,39,77,94,161,181],"to":[7,159,213],"determine":[8],"the":[9,20,115,194,217,226,235],"clinical":[10],"and":[11,16,48,67,82,102,150,163,168,178,240],"prognostic":[12],"features":[13],"leukemias":[15],"preleukemic":[17,55,179],"states,":[18],"whatever":[19],"mode":[21],"development,":[23],"observed":[24],"in":[25,79,220],"patients":[26,43,59,81,104,206],"after":[27,169],"treatment":[28],"breast":[30,46,92],"cancer.":[31],"PATIENTS":[32],"AND":[33],"METHODS:":[34],"A":[35],"retrospective":[36],"multicentric":[37],"analysis":[38],"made":[40],"121":[42],"treated":[44],"for":[45,99,109,199,203],"cancer":[47,93],"who":[49],"later":[50],"developed":[51],"leukemia":[52,134,140,177],"or":[53,97],"a":[54,145,237,241],"state.":[56],"Initially,":[57],"44":[58],"had":[60,64,69,84],"undergone":[61],"mastectomy,":[62],"72":[63],"conservative":[65],"surgery":[66],"119":[68],"locoregional":[70],"irradiation.":[71],"At":[72],"least":[73],"one":[74],"chemotherapy":[75,201],"session":[76],"performed":[78],"90":[80],"48":[83],"received":[85],"tamoxifen.":[86],"risk":[88,227],"relapse":[90],"high,":[95],"moderate":[96,208],"low":[98],"44,":[100],"46":[101],"24":[103],"respectively":[105,166],"(data":[106],"not":[107],"available":[108],"7":[110],"patients).":[111],"RESULTS:":[112],"By":[113],"class,":[114],"hematology":[116],"diseases":[117],"found":[118],"were:":[119],"myelodysplasia":[120],"(n":[121,129,135,141],"=":[122,130,136,142],"9),":[123],"refractory":[124],"anemia":[125],"with":[126,183,225],"blast":[127],"excess":[128],"7),":[131],"acute":[132,138,154],"lymphoblastic":[133],"6),":[137],"myoblastic":[139],"93":[143],"including":[144],"majority":[146],"type":[148,151],"2":[149],"4).":[152],"For":[153],"myeloblastic":[155],"leukemia,":[156],"mean":[157],"delay":[158],"onset":[160],"65":[162],"37":[164],"months":[165],"without":[167],"chemotherapy.":[170],"prognosis":[172],"these":[174],"cases":[175],"states":[180],"poor":[182],"an":[184],"overall":[185],"death":[186],"rate":[187],"86%.":[189],"CONCLUSION:":[190],"In":[191,234],"light":[192],"recent":[195],"development":[196],"indications":[198],"adjuvant":[200],"even":[202],"subgroups":[204],"at":[207],"risk,":[209],"it":[210],"is":[211],"important":[212],"more":[214],"precisely":[215],"assess":[216],"absolute":[218],"benefit":[219],"terms":[221],"survival":[223],"compared":[224],"severe":[229],"complications,":[230],"particular":[231],"secondary":[232],"leukemia.":[233],"future,":[236],"systematic":[238],"registry":[239],"case-control":[242],"are":[244],"required.":[245]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}