{"id":"https://openalex.org/W49952832","doi":"https://doi.org/10.1093/ajcp/68.3.355","title":"The Effects of \u201cAnti-platelet\u201d Drugs on Bleeding Time and Platelet Aggregation in Normal Human Subjects","display_name":"The Effects of \u201cAnti-platelet\u201d Drugs on Bleeding Time and Platelet Aggregation in Normal Human Subjects","publication_year":1977,"publication_date":"1977-09-01","ids":{"openalex":"https://openalex.org/W49952832","doi":"https://doi.org/10.1093/ajcp/68.3.355","mag":"49952832","pmid":"https://pubmed.ncbi.nlm.nih.gov/331937"},"language":"en","primary_location":{"id":"doi:10.1093/ajcp/68.3.355","doi":"https://doi.org/10.1093/ajcp/68.3.355","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/68.3.355","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104023039","display_name":"George R. Buchanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George R. Buchanan","raw_affiliation_strings":["Int Med - Chairman's Office"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Int Med - Chairman's Office","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vera Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vera Martin","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060473143","display_name":"Peter H. Levine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Levine","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037620821","display_name":"Kristine Scoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristine Scoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113755409","display_name":"Robert I. Handin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert I. Handin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":1.4061,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.79085373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"68","issue":"3","first_page":"355","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.9869999885559082},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bleeding-time","display_name":"bleeding time","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glyceryl-guaiacolate","display_name":"glyceryl guaiacolate","score":0.949999988079071},{"id":"https://openalex.org/keywords/diphenhydramine","display_name":"diphenhydramine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":1.0},{"id":"https://openalex.org/keywords/drug-effects-on-platelets","display_name":"drug effects on platelets","score":0.6309999823570251},{"id":"https://openalex.org/keywords/normal-volunteers","display_name":"normal volunteers","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2779216453","wikidata":"https://www.wikidata.org/wiki/Q489957","display_name":"Bleeding time","level":4,"score":0.9027976989746094},{"id":"https://openalex.org/C2781292560","wikidata":"https://www.wikidata.org/wiki/Q413486","display_name":"Diphenhydramine","level":3,"score":0.819075345993042},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.7500594258308411},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7439455986022949},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.7357364296913147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6688929200172424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6678681373596191},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.5238214135169983},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5143193006515503},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.513857364654541},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.4906062185764313},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.4852156937122345},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45354002714157104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22094279527664185},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.1506822109222412},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05594715476036072},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004155","descriptor_name":"Diphenhydramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006140","descriptor_name":"Guaifenesin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcp/68.3.355","doi":"https://doi.org/10.1093/ajcp/68.3.355","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/68.3.355","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:331937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/331937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974470683","https://openalex.org/W2070700855","https://openalex.org/W2319966559","https://openalex.org/W2093588234","https://openalex.org/W2069564967","https://openalex.org/W2025198200","https://openalex.org/W1965201330","https://openalex.org/W2164511280","https://openalex.org/W2332928979","https://openalex.org/W2032205507"],"abstract_inverted_index":{"The":[0,26],"effects":[1],"on":[2,81,105,130],"hemostasis":[3],"of":[4,22,34,47,68,87,119,138],"several":[5],"commonly":[6,121],"used":[7,122],"drugs":[8,124],"previously":[9],"described":[10],"as":[11],"inhibiting":[12],"platelet":[13,58],"function":[14],"were":[15,28],"evaluated":[16],"in":[17,134],"a":[18,31],"randomized,":[19],"double-blind":[20],"study":[21],"54":[23],"normal":[24,135],"volunteers.":[25],"subjects":[27],"each":[29],"given":[30],"single":[32,45],"dose":[33,46],"aspirin,":[35],"chlorpromazine,":[36],"glyceryl":[37],"guaiacolate,":[38],"diphenhydramine,":[39],"indomethacin":[40,69,88],"or":[41],"lactose":[42],"placebo.":[43],"A":[44],"aspirin":[48],"significantly":[49],"prolonged":[50],"the":[51,131],"template":[52],"bleeding":[53,82,91,106],"time":[54],"and":[55,61,70],"inhibited":[56,95],"secondary":[57],"aggregation":[59,73,96],"two":[60,75],"24":[62],"hours":[63,76],"after":[64,99],"ingestion.":[65],"Single":[66],"doses":[67,86,118],"chlorpromazine":[71],"affected":[72],"at":[74],"but":[77,101],"had":[78,102],"no":[79,103],"effect":[80,104,129],"time,":[83],"although":[84],"multiple":[85],"did":[89,109],"prolong":[90],"time.":[92,107],"Glyceryl":[93],"guaiacolate":[94],"one":[97],"hour":[98],"ingestion":[100],"Diphenhydramine":[108],"not":[110,143],"affect":[111],"either.":[112],"These":[113],"findings":[114],"suggest":[115],"that":[116],"standard":[117],"many":[120],"\"anti-platelet\"":[123],"may":[125,142],"have":[126],"little":[127],"clinical":[128],"hemostatic":[132],"mechanism":[133],"man.":[136],"Results":[137],"in-vitro":[139],"platelet-drug":[140],"incubations":[141],"be":[144],"directly":[145],"applicable":[146],"to":[147],"in-vivo":[148],"hemostasis.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}