{"id":"https://openalex.org/W49951573","doi":null,"title":"Immunological and non-immunological mechanisms of proteinuria.","display_name":"Immunological and non-immunological mechanisms of proteinuria.","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W49951573","mag":"49951573","pmid":"https://pubmed.ncbi.nlm.nih.gov/19816391"},"language":"en","primary_location":{"id":"pmid:19816391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19816391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva urologica e nefrologica = The Italian journal of urology and nephrology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109754336","display_name":"N. Braun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Braun","raw_affiliation_strings":["HELIOS Kliniken, Department of Nephrology and Dialysis Faculty of Medicine, University of Rostock, Rostock, Germany. norbert.braun@helios-kliniken.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HELIOS Kliniken, Department of Nephrology and Dialysis Faculty of Medicine, University of Rostock, Rostock, Germany. norbert.braun@helios-kliniken.de","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110897701","display_name":"Hermann\u2010Josef Gr\u00f6ne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Gr\u00f6ne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091868996","display_name":"Francesco Paolo Schena","orcid":"https://orcid.org/0000-0001-7927-5207","observed_orcids":["https://orcid.org/0000-0001-7927-5207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P Schena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2294,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63340061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"61","issue":"4","first_page":"385","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":1.0},{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.9290000200271606},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glomerular-basement-membrane","display_name":"glomerular basement membrane","score":0.8299999833106995},{"id":"https://openalex.org/keywords/slit-diaphragm","display_name":"slit diaphragm","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nephrin","display_name":"nephrin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/podocin","display_name":"podocin","score":1.0},{"id":"https://openalex.org/keywords/cd2ap","display_name":"CD2AP","score":0.9959999918937683},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6510000228881836},{"id":"https://openalex.org/keywords/immune-mediated-glomerulonephritis","display_name":"immune-mediated glomerulonephritis","score":0.6209999918937683},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8970000147819519},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9610000252723694},{"id":"https://openalex.org/keywords/podocyte-loss","display_name":"podocyte loss","score":0.6470000147819519},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2776855237","wikidata":"https://www.wikidata.org/wiki/Q22680259","display_name":"Podocin","level":5,"score":0.7701272964477539},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.6568900346755981},{"id":"https://openalex.org/C2780819817","wikidata":"https://www.wikidata.org/wiki/Q909653","display_name":"Nephrin","level":5,"score":0.5906800627708435},{"id":"https://openalex.org/C3018201436","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Slit diaphragm","level":5,"score":0.5645815134048462},{"id":"https://openalex.org/C2779937669","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Mesangium","level":4,"score":0.5455918908119202},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.5167598128318787},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.4974346458911896},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46083763241767883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4591621160507202},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.40710756182670593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4068286120891571},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.35676416754722595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26954901218414307},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.25499528646469116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20792675018310547}],"mesh":[{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050533","descriptor_name":"Glomerular Basement Membrane","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D050533","descriptor_name":"Glomerular Basement Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19816391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19816391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva urologica e nefrologica = The Italian journal of urology and nephrology","raw_type":"Journal Article"},{"id":"mag:49951573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19816391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082052279","https://openalex.org/W7213780242","https://openalex.org/W2108290932","https://openalex.org/W2095328109","https://openalex.org/W7097090576","https://openalex.org/W1998312206","https://openalex.org/W2038108331","https://openalex.org/W2955297634","https://openalex.org/W2017096105","https://openalex.org/W2132343147"],"abstract_inverted_index":{"Proteinuria":[0],"as":[1,161],"a":[2,6,38,44,101,180,191],"general":[3],"symptom":[4],"of":[5,9,17,30,43,65,84,92,108,140,148,154,182,190,193,198],"broad":[7],"range":[8],"different":[10],"diseases":[11],"can":[12,135],"result":[13,189],"from":[14,24],"gene":[15],"mutations":[16,121],"molecules":[18,125],"building":[19],"up":[20],"the":[21,31,71,82,85,90,93,105,109,143,177,188,194,201,205],"glomerular":[22,32,55],"sieve,":[23],"immune-mediated,":[25],"haemodynamic":[26],"or":[27,131],"metabolic":[28,159],"disturbances":[29],"filter.":[33],"This":[34],"filter":[35],"is":[36,61,187],"not":[37],"static":[39],"barrier":[40],"but":[41],"consists":[42],"highly":[45,195],"dynamic":[46],"interacting":[47],"podocyte":[48,183],"foot":[49,52,94,113],"process":[50,53],"to":[51,54,62],"basement":[56,144,202],"membrane":[57,145,203],"complex.":[58],"Its":[59],"function":[60],"prevent":[63],"leakage":[64],"macromolecules":[66],"and":[67,76,111,142,152,158,172,179,200,207],"blood":[68],"cells":[69,141,199],"into":[70],"urine.":[72],"Molecules":[73],"like":[74],"nephrin":[75],"podocin":[77],"are":[78,166],"directly":[79,126],"involved":[80],"in":[81,103,163,176],"formation":[83],"slit":[86],"diaphragm":[87],"located":[88],"at":[89],"end":[91],"processes.":[95],"Other":[96],"molecules,":[97],"i.e.":[98],"CD2AP,":[99],"play":[100],"role":[102],"organizing":[104],"correct":[106],"position":[107],"podocytes":[110],"its":[112],"processes":[114],"via":[115,146],"controlling":[116],"intra-cellular":[117],"actin":[118],"filaments.":[119],"Gene":[120],"coding":[122],"for":[123],"these":[124],"cause":[127],"proteinuric":[128],"diseases.":[129],"Autoantibodies":[130],"circulating":[132],"immune":[133],"complexes":[134],"destroy":[136],"this":[137],"fragile":[138,196],"network":[139,197],"accumulation":[147],"inflammatory":[149],"cells,":[150],"cytokines":[151],"generation":[153],"oxygen":[155],"radicals.":[156],"Hemodynamic":[157],"changes":[160],"seen":[162],"diabetic":[164],"nephropathy":[165],"associated":[167],"with":[168],"increased":[169],"TGF-ss":[170],"expression":[171],"extra-cellular":[173],"matrix":[174],"expansion":[175],"mesangium":[178],"decrease":[181],"numbers.":[184],"Thus,":[185],"proteinuria":[186],"disturbance":[192],"on":[204],"micro-anatomical":[206],"molecular":[208],"level.":[209]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}