{"id":"https://openalex.org/W49796418","doi":null,"title":"Radiation induced biomarkers of individual sensitivity to radiation therapy","display_name":"Radiation induced biomarkers of individual sensitivity to radiation therapy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W49796418","mag":"49796418"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-97123","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042994926","display_name":"Sara Ski\u00f6ld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sara Ski\u00f6ld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042994926"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.906000018119812},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5090000033378601},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7680000066757202},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/radiation-induced-skin-reactions","display_name":"radiation-induced skin reactions","score":0.6710000038146973},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8240000009536743},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.7860000133514404},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/personalized-radiotherapy","display_name":"personalized radiotherapy","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6988842487335205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5611619353294373},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.5426251888275146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39106228947639465},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3872908353805542},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3251282870769501},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.19074994325637817},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11990469694137573},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-97123","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:49796418","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:676039/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-97123","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97123","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W109457554","https://openalex.org/W130215997","https://openalex.org/W159285725","https://openalex.org/W1538513556","https://openalex.org/W1553763991","https://openalex.org/W1587493968","https://openalex.org/W1963973437","https://openalex.org/W1964157177","https://openalex.org/W1965809036","https://openalex.org/W1967529966","https://openalex.org/W1969186966","https://openalex.org/W1969775211","https://openalex.org/W1976196074","https://openalex.org/W1976903473","https://openalex.org/W1976954091","https://openalex.org/W1978281290","https://openalex.org/W1978627461","https://openalex.org/W1978724573","https://openalex.org/W1978948673","https://openalex.org/W1979254256","https://openalex.org/W1980026363","https://openalex.org/W1982087764","https://openalex.org/W1984684695","https://openalex.org/W1990970781","https://openalex.org/W1995446858","https://openalex.org/W1997285278","https://openalex.org/W1997471619","https://openalex.org/W1998263434","https://openalex.org/W2002894562","https://openalex.org/W2003872986","https://openalex.org/W2010740846","https://openalex.org/W2011804819","https://openalex.org/W2012158181","https://openalex.org/W2014036544","https://openalex.org/W2015107556","https://openalex.org/W2016899305","https://openalex.org/W2017275974","https://openalex.org/W2019963243","https://openalex.org/W2020142830","https://openalex.org/W2023627397","https://openalex.org/W2023677185","https://openalex.org/W2024727063","https://openalex.org/W2027214733","https://openalex.org/W2033102397","https://openalex.org/W2035154953","https://openalex.org/W2036911210","https://openalex.org/W2037184450","https://openalex.org/W2037865821","https://openalex.org/W2039866744","https://openalex.org/W2042339669","https://openalex.org/W2043441050","https://openalex.org/W2043945205","https://openalex.org/W2050568705","https://openalex.org/W2054148231","https://openalex.org/W2056106885","https://openalex.org/W2056601553","https://openalex.org/W2061726577","https://openalex.org/W2064575807","https://openalex.org/W2071217207","https://openalex.org/W2072729503","https://openalex.org/W2073854854","https://openalex.org/W2075638923","https://openalex.org/W2076762519","https://openalex.org/W2079952322","https://openalex.org/W2083514649","https://openalex.org/W2084491525","https://openalex.org/W2084800358","https://openalex.org/W2085042325","https://openalex.org/W2086860678","https://openalex.org/W2087290238","https://openalex.org/W2087870236","https://openalex.org/W2088021312","https://openalex.org/W2088754604","https://openalex.org/W2088792252","https://openalex.org/W2091066824","https://openalex.org/W2093666788","https://openalex.org/W2095297132","https://openalex.org/W2096136751","https://openalex.org/W2102258234","https://openalex.org/W2105080317","https://openalex.org/W2105364421","https://openalex.org/W2105924489","https://openalex.org/W2106880428","https://openalex.org/W2107043033","https://openalex.org/W2107215120","https://openalex.org/W2109317905","https://openalex.org/W2109543726","https://openalex.org/W2110873227","https://openalex.org/W2111141410","https://openalex.org/W2112699943","https://openalex.org/W2115712187","https://openalex.org/W2115781580","https://openalex.org/W2122621484","https://openalex.org/W2123447775","https://openalex.org/W2126928020","https://openalex.org/W2132975710","https://openalex.org/W2134258634","https://openalex.org/W2134715491","https://openalex.org/W2138544876","https://openalex.org/W2139014019","https://openalex.org/W2144318283","https://openalex.org/W2144383583","https://openalex.org/W2145954753","https://openalex.org/W2149884878","https://openalex.org/W2151576881","https://openalex.org/W2151736917","https://openalex.org/W2151892353","https://openalex.org/W2153684756","https://openalex.org/W2153716925","https://openalex.org/W2153853960","https://openalex.org/W2158420675","https://openalex.org/W2161940509","https://openalex.org/W2162333896","https://openalex.org/W2168508553","https://openalex.org/W2168891239","https://openalex.org/W2171465583","https://openalex.org/W2171697262","https://openalex.org/W2898172712","https://openalex.org/W4297168416","https://openalex.org/W4301863469"],"related_works":["https://openalex.org/W1979345943","https://openalex.org/W2313627938","https://openalex.org/W2045328677","https://openalex.org/W3195414690","https://openalex.org/W2968339581","https://openalex.org/W4205955118","https://openalex.org/W7196965506","https://openalex.org/W3130575316","https://openalex.org/W3020228562","https://openalex.org/W2977483924"],"abstract_inverted_index":{"Fifty":[0],"percent":[1],"of":[2,29,44,105,118,147,152,174,188,198,226,281],"solid":[3],"cancers":[4],"are":[5,98],"treated":[6],"with":[7],"radiation":[8,75,132,176,227,286],"therapy":[9],"(RT).":[10],"The":[11,101,138,238,278],"dose":[12,60,136,206],"used":[13,220],"in":[14,150,164,202,207,274,301],"RT":[15,69],"is":[16,310],"adjusted":[17],"to":[18,109,113,123,185,204,221,305],"the":[19,30,42,45,84,94,115,126,129,143,196,223,241,248,259,268,297],"most":[20,85],"sensitive":[21,228,287,298],"individuals":[22],"so":[23],"that":[24,145,167,247,296,308],"not":[25,99],"more":[26,78],"than":[27],"5%":[28],"patients":[31,46,79,121,288,299],"will":[32,47],"have":[33,55,190,252],"severe":[34,86],"adverse":[35,87,154],"healthy":[36],"tissue":[37],"effects.":[38],"As":[39],"a":[40,49,57,63,311],"consequence,":[41],"majority":[43],"receive":[48],"suboptimal":[50],"dose,":[51],"as":[52],"they":[53],"would":[54,80],"tolerated":[56],"higher":[58],"total":[59],"and":[61,83,122,131,229,262,307],"received":[62],"better":[64,124],"tumor":[65],"control.":[66],"Thus,":[67],"if":[68],"could":[70,89],"be":[71,81,90,162],"individualized":[72],"based":[73,141],"on":[74,142],"sensitivity":[76],"(RS),":[77],"cured":[82],"reactions":[88,156],"avoided.":[91],"At":[92],"present":[93],"mechanisms":[95,127],"behind":[96,128],"RS":[97,117,130,189],"known.":[100],"long":[102],"term":[103],"aim":[104],"this":[106,180],"thesis":[107],"was":[108,140,212,218,272],"develop":[110],"diagnostic":[111],"tools":[112],"assess":[114],"individual":[116,148],"breast":[119,158],"cancer":[120,159],"understand":[125],"effects":[133],"after":[134,157,263,276],"low":[135,172,205],"exposures.":[137],"approach":[139],"hypothesis":[144],"biomarkers":[146,187],"RS,":[149],"terms":[151],"acute":[153],"skin":[155],"RT,":[160],"can":[161],"found":[163],"whole":[165,210],"blood":[166,211],"has":[168],"been":[169,191],"stressed":[170],"by":[171],"doses":[173],"ionizing":[175],"(IR).":[177],"To":[178],"reach":[179],"goal":[181],"two":[182,249],"different":[183,253],"approaches":[184],"identify":[186],"investigated.":[192],"A":[193],"protocol":[194,217],"for":[195,314],"analysis":[197],"differential":[199],"protein":[200,234,254],"expression":[201,255],"response":[203,304],"vitro":[208],"irradiated":[209],"developed":[213],"(paper":[214,244],"I).":[215],"This":[216,294],"then":[219],"investigate":[222],"proteomic":[224],"profile":[225],"normo-sensitive":[230,292],"patients,":[231],"using":[232],"isotope-coded":[233],"labeled":[235],"proteomics":[236],"(ICPL).":[237],"results":[239],"from":[240,285,291],"ICPL":[242],"study":[243],"III)":[245],"show":[246],"patient":[250],"groups":[251],"profiles":[256],"both":[257],"at":[258],"basal":[260],"level":[261],"IR.":[264,277],"In":[265],"paper":[266],"II":[267],"potential":[269,312],"biomarker":[270,313],"8-oxo-dG":[271,284,309],"investigated":[273],"serum":[275],"relative":[279],"levels":[280],"IR":[282,306],"induced":[283],"differ":[289,300],"significantly":[290],"patients.":[293],"indicates":[295],"their":[302],"cellular":[303],"RS.":[315]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
