{"id":"https://openalex.org/W49787237","doi":null,"title":"Response of humans to gamma-irradiated reference Escherichia coli endotoxin.","display_name":"Response of humans to gamma-irradiated reference Escherichia coli endotoxin.","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W49787237","mag":"49787237","pmid":"https://pubmed.ncbi.nlm.nih.gov/2697758"},"language":"en","primary_location":{"id":"pmid:2697758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2697758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055938092","display_name":"Ronald J. Elin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Elin","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Csako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1644,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.42681237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"1","first_page":"17","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/o-antigen","display_name":"O-antigen","score":0.8450000286102295},{"id":"https://openalex.org/keywords/fever-response","display_name":"fever response","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.996999979019165},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9440000057220459},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.8709999918937683},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.6227672100067139},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6141104102134705},{"id":"https://openalex.org/C3017806408","wikidata":"https://www.wikidata.org/wiki/Q92772955","display_name":"Gamma irradiation","level":3,"score":0.47444355487823486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4539858400821686},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4522538483142853},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4495089650154114},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43906983733177185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.400725781917572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39414381980895996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37936291098594666},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3237115740776062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2198302447795868},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2697758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2697758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},{"id":"mag:49787237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2697758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3118355225","https://openalex.org/W2091342231","https://openalex.org/W1768515342","https://openalex.org/W7100513925","https://openalex.org/W1903162553","https://openalex.org/W2798718444","https://openalex.org/W2135322342","https://openalex.org/W1992174115","https://openalex.org/W2229720644","https://openalex.org/W2395289612"],"abstract_inverted_index":{"This":[0],"study":[1],"assesses":[2],"the":[3,45,68,73,78,112,115,125,129,151,154,173,200,220],"effect":[4],"of":[5,7,54,62,77,82,93,132,156,163,207],"gamma-irradiation":[6,51],"endotoxin":[8,19,40,49,69,83,126,166,211],"given":[9,85],"intravenously":[10,86],"to":[11,67,72,87,114,128,215,225],"healthy":[12],"human":[13],"volunteers.":[14],"The":[15,96,179],"national":[16],"reference":[17],"standard":[18],"derived":[20],"from":[21,223],"E.":[22],"coli":[23],"was":[24,84,167],"placed":[25],"in":[26,29,171,188,212,219],"aqueous":[27],"medium":[28],"sterile-sealed":[30],"ampoules":[31],"and":[32,102,107,143,199],"divided":[33],"into":[34],"four":[35,79,88],"groups.":[36],"One":[37],"group":[38],"received":[39,48],"with":[41,50,124,184],"no":[42,119,146],"radiation":[43,63,133],"while":[44],"other":[46],"three":[47],"at":[52,90],"doses":[53,61,162],"0.18,":[55],"0.36,":[56],"or":[57],"1.08":[58],"Mrad.":[59],"These":[60],"cause":[64],"characteristic":[65],"alterations":[66],"molecule,":[70],"primarily":[71,218],"O-polysaccharide":[74,221],"moiety.":[75],"Each":[76],"different":[80],"preparations":[81],"volunteers":[89],"a":[91],"concentration":[92],"4":[94],"ng/kg.":[95],"responses":[97],"for":[98,210],"clinical":[99,120],"symptoms,":[100],"cortisol,":[101],"growth":[103],"hormone":[104],"were":[105,122,158],"significantly":[106,168,183],"progressively":[108],"reduced":[109],"by":[110,160],"increasing":[111,161],"irradiation":[113],"endotoxin.":[116,178],"Most":[117],"strikingly,":[118],"symptoms":[121],"noted":[123],"exposed":[127],"highest":[130],"dose":[131],"(1.08":[134],"Mrad).":[135],"Fever,":[136],"vital":[137],"signs,":[138],"white":[139,190],"blood":[140,191],"cell":[141,192],"count,":[142],"differential":[144],"exhibited":[145],"statistically":[147],"significant":[148],"differences":[149],"among":[150],"groups,":[152],"but":[153],"kinetics":[155],"change":[157,187],"altered":[159],"gamma-irradiation.":[164,226],"Irradiated":[165],"more":[169],"effective":[170],"decreasing":[172],"platelet":[174],"count":[175,193,197],"than":[176],"untreated":[177],"fever":[180],"index":[181],"correlated":[182],"maximum":[185],"temperature,":[186,189],"index,":[194,198],"mature":[195],"neutrophil":[196],"cortisol":[201],"index.":[202],"Thus,":[203],"there":[204],"is":[205],"dissociation":[206],"biological":[208],"activities":[209],"humans":[213],"due":[214],"molecular":[216],"changes":[217],"moiety":[222],"exposure":[224]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}