{"id":"https://openalex.org/W49692196","doi":null,"title":"[Absorption, excretion and distribution of amikacin following intravenous drip infusion. Intravenous drip infusion, one shot intravenous injection and intramuscular administration of amikacin in dogs, rabbits and rats].","display_name":"[Absorption, excretion and distribution of amikacin following intravenous drip infusion. Intravenous drip infusion, one shot intravenous injection and intramuscular administration of amikacin in dogs, rabbits and rats].","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W49692196","mag":"49692196","pmid":"https://pubmed.ncbi.nlm.nih.gov/7154249"},"language":"ja","primary_location":{"id":"pmid:7154249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7154249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030715946","display_name":"H. Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049720120","display_name":"K Ochiai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ochiai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Nakajima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nakajima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112661840","display_name":"M Matsuzaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Matsuzaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00359636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"8","first_page":"2034","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amikacin-sulfate","display_name":"amikacin sulfate","score":0.9309999942779541},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.718999981880188},{"id":"https://openalex.org/keywords/intravenous-injection","display_name":"intravenous injection","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9409999847412109},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.7559999823570251},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9850000143051147},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.8880000114440918},{"id":"https://openalex.org/keywords/one-compartment-model","display_name":"one-compartment model","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.46799999475479126},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.996999979019165},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":1.0}],"concepts":[{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6251040101051331},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.624570369720459},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6192104816436768},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5575500726699829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5458831787109375},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.48798054456710815},{"id":"https://openalex.org/C2779591255","wikidata":"https://www.wikidata.org/wiki/Q426081","display_name":"Xylazine","level":3,"score":0.47761934995651245},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.47032487392425537},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4284519851207733},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3782614767551422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34404754638671875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3423070013523102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2916366755962372},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.09815910458564758},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000583","descriptor_name":"Amikacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000583","descriptor_name":"Amikacin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000583","descriptor_name":"Amikacin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007612","descriptor_name":"Kanamycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7154249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7154249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese journal of antibiotics","raw_type":"Comparative Study"},{"id":"mag:366038365","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40000017227","pdf_url":null,"source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Antibiotics","raw_type":null},{"id":"mag:49692196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7154249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174058","https://openalex.org/W6979848956","https://openalex.org/W2420830324","https://openalex.org/W2423505123","https://openalex.org/W2126758744","https://openalex.org/W2170549542","https://openalex.org/W324274179","https://openalex.org/W2325051279","https://openalex.org/W2003492287","https://openalex.org/W22744567"],"abstract_inverted_index":{"Absorption,":[0],"excretion":[1,45],"and":[2,21,23,35,43,56,60,76,88,94,111,119,124,179,187,193,203,216,231,237,242,258,300,309,324],"distribution":[3],"of":[4,46,64,74,116,206,226,285,312],"amikacin":[5],"sulfate":[6],"(AMK)":[7],"obtained":[8,28,70,222],"following":[9,48,67,142,172,185,208,267],"administration":[10],"by":[11,292],"drip":[12],"intravenous":[13,32],"infusion":[14,33],"(d.i.v.)":[15],"were":[16,24,50,69,98,161,189,197,212,221,245,260,271,305,316,328],"studied":[17],"in":[18,58,92,95,102,122,128,136,177,180,214,228,249,255,269,278,317,336],"dogs,":[19,137],"rabbits":[20],"rats,":[22],"compared":[25,51],"with":[26,52,274,332],"those":[27,53,194,254],"after":[29,54,151,159,195,326],"one":[30,303],"shot":[31],"(i.v.)":[34],"intramuscular":[36],"injection":[37],"(i.m.).":[38],"1.":[39],"The":[40,62,153,182,201,218,247,264,320],"plasma":[41,65,105,140,154,170,265,297,321],"concentration":[42,66,141,248,298],"urinary":[44,183],"AMK":[47,207],"d.i.v.":[49,68,75,110,145,175,186,211,227,268,327],"i.v.":[55,160,188],"i.m.":[57,112,152,196],"dogs":[59,93,123,178,270],"rabbits.":[61,96,129,181,217],"peaks":[63],"at":[71,113,125,156,223],"the":[72,85,89,103,114,131,138,168,224,235,275,279,283,295,301,310,313,333,337],"end":[73,225],"it":[77],"was":[78,146,234,251],"clearly":[79],"observed":[80],"a":[81],"linear":[82],"dependence":[83],"between":[84,107,294],"peak":[86,104,139,169,219],"values":[87],"doses":[90,115],"both":[91,176],"There":[97],"no":[99],"significant":[100],"differences":[101],"concentrations":[106,155,171,205,220,266,322],"1":[108,143,173,209],"hour":[109,144,174,210],"25":[117],"mg/kg":[118,121],"50":[120],"each":[126],"dose":[127,133],"At":[130],"higher":[132,148],"(100":[134],"mg/kg)":[135],"slightly":[147],"than":[149,191,307],"that":[150],"10":[157],"minutes":[158],"elevated":[162],"about":[163,198],"twice":[164],"as":[165,167,282],"high":[166],"recoveries":[184],"more":[190],"90%":[192],"85%.":[199],"2.":[200],"tissue":[202,230],"organ":[204],"studies":[213],"rats":[215],"any":[229],"organ.":[232],"Kidney":[233],"highest":[236],"plasma,":[238],"lungs,":[239],"heart,":[240],"stomach":[241],"so":[243],"on":[244],"followed.":[246],"kidney":[250],"remained":[252],"but":[253],"other":[256],"tissues":[257],"organs":[259],"decreased":[261],"soon.":[262],"3.":[263],"well":[272],"agreed":[273,330],"pharmacokinetic":[276,314,334],"analysis":[277,335],"two-compartment":[280],"model,":[281],"means":[284],"relative":[286],"errors":[287],"(1Xm":[288],"-":[289],"Xc1":[290],"divided":[291],"Xc)":[293],"measured":[296],"(Xm)":[299],"calculated":[302],"(Xc)":[304],"less":[306],"10%":[308],"deviations":[311],"parameters":[315],"little":[318],"ranges.":[319],"during":[323],"just":[325],"also":[329],"enough":[331],"one-compartment":[338],"model.":[339]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}