{"id":"https://openalex.org/W49625455","doi":null,"title":"Sulfonylurea effects on target tissues for insulin.","display_name":"Sulfonylurea effects on target tissues for insulin.","publication_year":1984,"publication_date":"1984-05-01","ids":{"openalex":"https://openalex.org/W49625455","mag":"49625455","pmid":"https://pubmed.ncbi.nlm.nih.gov/6376028"},"language":"en","primary_location":{"id":"pmid:6376028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6376028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000164054","display_name":"Michael L. McCaleb","orcid":"https://orcid.org/0000-0001-9927-3233","observed_orcids":["https://orcid.org/0000-0001-9927-3233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L McCaleb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021590450","display_name":"Bruce L. Maloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B L Maloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087871029","display_name":"S Nowak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Nowak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000487521","display_name":"Lockwood Dh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Lockwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1275,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.305438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7 Suppl 1","issue":null,"first_page":"42","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.1995999962091446,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5130000114440918},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-transport","display_name":"insulin-stimulated glucose transport","score":0.7229999899864197},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7919999957084656},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7710000276565552},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/transglutaminase","display_name":"transglutaminase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tolazamide","display_name":"tolazamide","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glipizide","display_name":"glipizide","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8430569171905518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.828127920627594},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8092057704925537},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8008434176445007},{"id":"https://openalex.org/C2779555806","wikidata":"https://www.wikidata.org/wiki/Q3108899","display_name":"Glipizide","level":3,"score":0.7938625812530518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6791749000549316},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6259627342224121},{"id":"https://openalex.org/C2778854520","wikidata":"https://www.wikidata.org/wiki/Q418776","display_name":"Sulfonylurea","level":3,"score":0.6161265969276428},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5663811564445496},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4810048043727875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4736170470714569},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.44768595695495605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.193252295255661},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014042","descriptor_name":"Tolazamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6376028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6376028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"mag:49625455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6376028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083460168","https://openalex.org/W2120212319","https://openalex.org/W1547486953","https://openalex.org/W2044328678","https://openalex.org/W2015578956","https://openalex.org/W2033324666","https://openalex.org/W2467906684","https://openalex.org/W2010837449","https://openalex.org/W2027788041","https://openalex.org/W1968647541"],"abstract_inverted_index":{"We":[0],"have":[1],"examined":[2],"the":[3,32,41,96,108,113,119,134,144,157,160,175,180],"nonpancreatic":[4],"actions":[5],"of":[6,11,26,43,51,58,67,98,107,121,138,159,174],"sulfonylureas":[7,83,155],"on":[8,112,124],"multiple":[9],"aspects":[10],"insulin":[12,60,86,109,181],"responsiveness":[13,158],"in":[14,37,88,129,135,147,183],"two":[15],"target":[16,161],"tissues":[17,162],"for":[18,75,163],"insulin,":[19],"liver":[20],"and":[21,28,56],"fat.":[22],"In":[23],"vivo":[24,136],"administration":[25,137],"tolazamide":[27],"glipizide":[29],"reduced":[30],"significantly":[31],"postabsorptive":[33],"serum":[34],"glucose":[35,100],"levels":[36,42],"rats":[38],"without":[39],"altering":[40],"insulin.":[44,164],"This":[45],"was":[46,62,94,104],"consistent":[47,117],"with":[48,82,118,132,179],"extrapancreatic":[49],"sites":[50],"drug":[52],"action.":[53],"The":[54,91,151],"number":[55],"affinity":[57],"hepatic":[59,149],"receptors":[61,110],"not":[63,142],"different":[64],"from":[65],"those":[66],"control":[68],"rats.":[69],"Using":[70],"a":[71,79],"tissue":[72],"culture":[73],"system":[74],"rat":[76,148],"adipose":[77,114],"tissue,":[78],"20-h":[80],"treatment":[81,131],"markedly":[84],"potentiated":[85],"action":[87],"fat":[89],"cells.":[90],"primary":[92],"augmentation":[93],"at":[95],"level":[97],"insulin-stimulated":[99],"transport.":[101],"Again,":[102],"there":[103],"no":[105],"alteration":[106],"located":[111],"tissue.":[115,150],"Furthermore,":[116],"lack":[120],"an":[122],"influence":[123],"insulin-induced":[125],"receptor":[126],"loss":[127],"after":[128],"vitro":[130],"sulfonylureas,":[133],"these":[139,166],"agents":[140,168],"did":[141],"alter":[143],"transglutaminase":[145],"activity":[146],"data":[152],"demonstrate":[153],"that":[154],"potentiate":[156],"Thus,":[165],"hypoglycemic":[167],"probably":[169],"act":[170],"by":[171],"correcting":[172],"some":[173],"cellular":[176],"lesions":[177],"associated":[178],"resistance":[182],"type":[184],"II":[185],"diabetes":[186],"mellitus.":[187]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
