{"id":"https://openalex.org/W49611758","doi":null,"title":"IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis.","display_name":"IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis.","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W49611758","mag":"49611758","pmid":"https://pubmed.ncbi.nlm.nih.gov/12202520"},"language":"en","primary_location":{"id":"pmid:12202520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12202520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003822550","display_name":"Ravi B Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi B Berger","raw_affiliation_strings":["Department of Ophthalmology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028763269","display_name":"Nathan M. Blackwell","orcid":"https://orcid.org/0000-0002-7242-5812","observed_orcids":["https://orcid.org/0000-0002-7242-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathan M Blackwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080203373","display_name":"Jonathan H. Lass","orcid":"https://orcid.org/0000-0002-3289-3443","observed_orcids":["https://orcid.org/0000-0002-3289-3443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan H Lass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054362758","display_name":"Eugenia Diaconu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenia Diaconu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085795028","display_name":"Eric M. Pearlman","orcid":"https://orcid.org/0000-0003-0137-7582","observed_orcids":["https://orcid.org/0000-0003-0137-7582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Pearlman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8821,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.73063091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"43","issue":"9","first_page":"2992","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onchocerca-volvulus","display_name":"Onchocerca volvulus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/onchocerciasis","display_name":"onchocerciasis","score":0.925000011920929},{"id":"https://openalex.org/keywords/keratitis","display_name":"keratitis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/eosinophil-recruitment","display_name":"eosinophil recruitment","score":0.8040000200271606},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9549999833106995},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":1.0},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cornea","display_name":"cornea","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ocular-allergy","display_name":"ocular allergy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/parasitic-eye-infection","display_name":"ocular parasitic infection","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.656000018119812},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2779027325","wikidata":"https://www.wikidata.org/wiki/Q137224","display_name":"Onchocerca volvulus","level":3,"score":0.7915810942649841},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7268985509872437},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6162628531455994},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6128994822502136},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.49477618932724},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4446639120578766},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.440887451171875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43392807245254517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33914268016815186},{"id":"https://openalex.org/C2780727990","wikidata":"https://www.wikidata.org/wiki/Q1137321","display_name":"Onchocerciasis","level":2,"score":0.17669349908828735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015827","descriptor_name":"Onchocerciasis, Ocular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015827","descriptor_name":"Onchocerciasis, Ocular","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D015827","descriptor_name":"Onchocerciasis, Ocular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017181","descriptor_name":"Onchocerca volvulus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12202520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12202520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:49611758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12202520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7921581078","display_name":"The Role of Wolbachia Endobacteria in River Blindness","funder_award_id":"R01EY010320","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000887781","display_name":"CWRU NEI Vision Center Core Grant","funder_award_id":"P30EY011373","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W35047647","https://openalex.org/W72669700","https://openalex.org/W74833083","https://openalex.org/W144012834","https://openalex.org/W169105841","https://openalex.org/W203679324","https://openalex.org/W325628129","https://openalex.org/W1500592259","https://openalex.org/W1523715800","https://openalex.org/W1534379527","https://openalex.org/W1594137577","https://openalex.org/W1599682912","https://openalex.org/W1630729294","https://openalex.org/W1972624864","https://openalex.org/W1995297089","https://openalex.org/W2004712248","https://openalex.org/W2010232855","https://openalex.org/W2010414925","https://openalex.org/W2016419966","https://openalex.org/W2023995274","https://openalex.org/W2027552966","https://openalex.org/W2033959129","https://openalex.org/W2058266118","https://openalex.org/W2081802477","https://openalex.org/W2086973195","https://openalex.org/W2091186803","https://openalex.org/W2095127706","https://openalex.org/W2109492494","https://openalex.org/W2123571538","https://openalex.org/W2124566107","https://openalex.org/W2125805192","https://openalex.org/W2154416360","https://openalex.org/W2166654677","https://openalex.org/W2168950538","https://openalex.org/W2398062214","https://openalex.org/W2416676694","https://openalex.org/W2440570020","https://openalex.org/W4313335026"],"related_works":["https://openalex.org/W2113465307","https://openalex.org/W1943446570","https://openalex.org/W2166654677","https://openalex.org/W35047647","https://openalex.org/W2004712248","https://openalex.org/W1996255728","https://openalex.org/W2009846124","https://openalex.org/W1982775201","https://openalex.org/W2014698041","https://openalex.org/W2281138607"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"presence":[2],"of":[3,12,25,37,47,54,67,87,94,98,109,115,128,140,155,161,165,177,181,211],"eosinophilic":[4],"granulocytes":[5],"in":[6,44,130,152,205],"ocular":[7,206],"tissue":[8],"is":[9],"a":[10,22,88,141,199],"hallmark":[11],"the":[13,31,35,38,50,101,168,184,212],"host":[14],"response":[15],"to":[16,49,82,100,145,167,183],"environmental":[17],"and":[18,42,70,73,96,157,179,191,193,208],"parasite":[19],"allergens.":[20],"Using":[21],"mouse":[23],"model":[24],"Onchocerca":[26],"volvulus-mediated":[27,132],"keratitis":[28,133],"(river":[29],"blindness),":[30],"present":[32],"study":[33],"examined":[34],"role":[36],"cytokines":[39,197],"interleukin":[40],"(IL)-4":[41],"IL-13":[43,71,118,158],"regulating":[45],"recruitment":[46,97,160,180],"eosinophils":[48,99,182],"cornea":[51,102,185],"through":[52],"expression":[53,127,176],"intercellular":[55],"cell":[56],"adhesion":[57],"molecule":[58],"(ICAM)-1.":[59],"METHODS:":[60],"C57BL/6":[61],"mice":[62],"received":[63],"an":[64,84],"intrastromal":[65,85],"injection":[66,80,86,114,139],"recombinant":[68,121],"IL-4":[69,146,156,190],"(rIL-4":[72],"IL-13)":[74],"or":[75,117,147],"were":[76,103],"immunized":[77],"by":[78,105,189],"subcutaneous":[79],"prior":[81],"receiving":[83],"soluble":[89],"O.":[90,131],"volvulus":[91],"extract.":[92],"Expression":[93,108],"ICAM-1":[95,110,129,178],"monitored":[104],"immunohistochemistry.":[106],"RESULTS:":[107],"was":[111,134],"elevated":[112],"after":[113,137],"rIL-4":[116],"together":[119],"with":[120],"tumor":[122],"necrosis":[123],"factor":[124],"(rTNF)-alpha.":[125],"Conversely,":[126],"significantly":[135],"reduced":[136],"subconjunctival":[138],"monoclonal":[142],"antibody":[143],"(mAb)":[144],"IL-13.":[148],"In":[149],"addition,":[150],"combined":[151],"vivo":[153],"neutralization":[154],"inhibited":[159],"eosinophils,":[162],"but":[163],"not":[164],"neutrophils,":[166],"corneal":[169],"stroma.":[170],"CONCLUSIONS:":[171],"These":[172],"findings":[173],"demonstrate":[174],"that":[175,195],"are":[186,198],"tightly":[187],"regulated":[188],"IL-13,":[192],"indicate":[194],"these":[196],"potential":[200],"target":[201],"for":[202],"immune":[203],"intervention":[204],"allergy":[207],"parasitic":[209],"infections":[210],"eye.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
