{"id":"https://openalex.org/W49539194","doi":null,"title":"[Evaluation of type IV collagen in patients with various thyroid disease].","display_name":"[Evaluation of type IV collagen in patients with various thyroid disease].","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W49539194","mag":"49539194","pmid":"https://pubmed.ncbi.nlm.nih.gov/8295344"},"language":"ja","primary_location":{"id":"pmid:8295344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8295344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rinsho byori. The Japanese journal of clinical pathology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y Senda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Senda","raw_affiliation_strings":["Central Clinical Laboratory, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical Laboratory, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069674279","display_name":"M Nishibu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nishibu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Kawai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kawai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025471308","display_name":"Yusuke Mizukami","orcid":"https://orcid.org/0000-0002-1068-7024","observed_orcids":["https://orcid.org/0000-0002-1068-7024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Mizukami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045431309","display_name":"Takashi Hashimoto","orcid":"https://orcid.org/0000-0002-0144-3255","observed_orcids":["https://orcid.org/0000-0002-0144-3255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hashimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00527823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"41","issue":"12","first_page":"1338","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":1.0},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/thyroid-hormone-levels","display_name":"thyroid hormone levels","score":0.7889999747276306},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/antithyroid-drug-therapy","display_name":"antithyroid drug therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/thyroid-function-assessment","display_name":"thyroid function assessment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/triple-helical-domain","display_name":"triple-helical domain","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.8703463077545166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7497501969337463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7160469889640808},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6695477962493896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6628482341766357},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6124314665794373},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.5353671908378601},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.5094712376594543},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.48343953490257263},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25413838028907776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14548027515411377}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8295344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8295344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rinsho byori. The Japanese journal of clinical pathology","raw_type":"English Abstract"},{"id":"mag:49539194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8295344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005693474","https://openalex.org/W4301735576","https://openalex.org/W2374117899","https://openalex.org/W2420951397","https://openalex.org/W2082645791","https://openalex.org/W2410346386","https://openalex.org/W2404835632","https://openalex.org/W7165764537","https://openalex.org/W2057083257","https://openalex.org/W3029872815"],"abstract_inverted_index":{"Serum":[0],"level":[1,20,24,58,96,122,154,165],"of":[2,36,59,97,123,155,179],"type":[3,28,60,98,124,156],"IV":[4,29,61,99,125,157,173],"collagen":[5,30,62,100,126,158,174],"was":[6,25,31,63,81,104,127,137],"measured":[7,32],"in":[8,66,73,101,128,131,166],"104":[9],"patients":[10,69,103],"with":[11,71,168],"various":[12,169],"thyroid":[13,22,87,163,170,186],"disease,":[14],"and":[15,21,52,76,86],"the":[16,34,67,135,152,180,185],"relationship":[17],"between":[18,83],"its":[19,84,189],"hormone":[23,88,164],"examined.":[26],"The":[27,56,94,120],"by":[33],"method":[35],"one":[37,178],"step":[38],"sandwich":[39],"enzyme":[40],"immunoassay":[41],"(EIA)":[42],"using":[43],"two":[44],"distinct":[45],"monoclonal":[46],"antibodies":[47],"recognized":[48],"triple-helical":[49],"(TH)":[50],"domain":[51],"7-S":[53],"domain,":[54],"respectively.":[55],"serum":[57,121,153],"significantly":[64],"high":[65,140],"hyperthyroid":[68,102],"compared":[70],"that":[72,151],"normal":[74,107,129,141],"controls,":[75],"a":[77],"significant":[78],"positive":[79],"correlation":[80],"found":[82],"value":[85,136],"levels":[89],"(T3,":[90],"T4,":[91],"FT3,":[92],"FT4).":[93],"elevated":[95],"decreased":[105],"to":[106,112,139,162],"level,":[108],"when":[109],"they":[110],"became":[111],"euthyroid":[113],"after":[114,143],"antithyroid":[115],"drug":[116],"therapy":[117,145],"for":[118,146,183],"hyperthyroidism.":[119],"range":[130,142],"hypothyroid":[132],"patients,":[133],"but":[134],"increased":[138],"T4-replacement":[144],"hypothyroidism.":[147],"This":[148],"evidence":[149],"indicates":[150],"is":[159,191],"closely":[160],"related":[161],"patient":[167],"disease.":[171],"Type":[172],"concentration":[175],"might":[176],"be":[177],"useful":[181],"variables":[182],"evaluating":[184],"function,":[187],"although":[188],"mechanism":[190],"not":[192],"elucidated.":[193]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}