{"id":"https://openalex.org/W49451120","doi":null,"title":"Effects of epidural analgesia and atropine on heart rate and blood pressure variability: implications for the interpretation of beat-to-beat fluctuations.","display_name":"Effects of epidural analgesia and atropine on heart rate and blood pressure variability: implications for the interpretation of beat-to-beat fluctuations.","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W49451120","mag":"49451120","pmid":"https://pubmed.ncbi.nlm.nih.gov/8174538"},"language":"en","primary_location":{"id":"pmid:8174538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of anaesthesiology","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W49451120"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059222565","display_name":"Gert Jan Scheffer","orcid":"https://orcid.org/0000-0003-4098-8079","observed_orcids":["https://orcid.org/0000-0003-4098-8079"]},"institutions":[{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4405257531"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G J Scheffer","raw_affiliation_strings":["Department of Anaesthesiology, ICaR-VU, Free University Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, ICaR-VU, Free University Hospital, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405257531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038255916","display_name":"Ben J. TenVoorde","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J TenVoorde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057130869","display_name":"John M. Karemaker","orcid":"https://orcid.org/0000-0003-0142-5425","observed_orcids":["https://orcid.org/0000-0003-0142-5425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Karemaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109983173","display_name":"Henk H. Ros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H H Ros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1122,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.86655187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"2","first_page":"75","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.8489999771118164},{"id":"https://openalex.org/keywords/blood-pressure-variability","display_name":"blood pressure variability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epidural-analgesia","display_name":"epidural analgesia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.7139999866485596},{"id":"https://openalex.org/keywords/parasympathetic-blockade","display_name":"parasympathetic blockade","score":0.8479999899864197},{"id":"https://openalex.org/keywords/spectral-analysis","display_name":"spectral analysis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/cardiovascular-regulation","display_name":"cardiovascular regulation","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.8367787599563599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7898542284965515},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.7897849082946777},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7519252300262451},{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.6124923229217529},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.5593132972717285},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5547828078269958},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.5118362307548523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48520568013191223},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4767906665802002},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4321780800819397},{"id":"https://openalex.org/C10928738","wikidata":"https://www.wikidata.org/wiki/Q1195426","display_name":"Vagal tone","level":5,"score":0.4176996350288391},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.4139777421951294},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.4117274880409241},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015360","descriptor_name":"Analgesia, Epidural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8174538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of anaesthesiology","raw_type":"Journal Article"},{"id":"mag:49451120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8174538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980806135","https://openalex.org/W2158361166","https://openalex.org/W2038208807","https://openalex.org/W2094896713","https://openalex.org/W2039448758","https://openalex.org/W1984874596","https://openalex.org/W2135725386","https://openalex.org/W2076975832","https://openalex.org/W2423587851","https://openalex.org/W2030622806"],"abstract_inverted_index":{"Cardiovascular":[0],"variables":[1],"such":[2],"as":[3],"heart":[4,56,64,74,107,118,130,157,179,203],"rate,":[5],"arterial":[6],"blood":[7,67,86,139,160,188,206],"pressure,":[8,87],"stroke":[9],"volume":[10],"and":[11,51,66,106,127,159,166,194,205],"the":[12,25,42,55,60,90,117,122,125,172,184,196,212],"shape":[13],"of":[14,24,28,44,54,63,85,103,116,155,217],"electrocardiographic":[15],"complexes":[16],"all":[17],"vary":[18],"beat-by-beat.":[19],"This":[20],"variability":[21,62],"occurs":[22],"because":[23],"dynamic":[26],"response":[27,186],"cardiovascular":[29,35,164],"regulatory":[30],"systems":[31],"to":[32,41,99,183,187],"perturbations":[33],"in":[34,69,73,124,138,142,178,201,211],"function.":[36],"We":[37],"applied":[38],"spectral":[39],"analysis":[40],"effects":[43],"sympathetic":[45,100,213],"vasomotor":[46,104,218],"blockade":[47,53,115,147],"by":[48,57,81,89,119,148,192],"epidural":[49,149],"analgesia":[50,150],"parasympathetic":[52,114],"atropine":[58,120],"on":[59],"beat-to-beat":[61],"rate":[65,75,131,158,180,204],"pressure":[68,140,189,207],"humans.":[70],"High-frequency":[71],"fluctuations":[72,84,94,141,154,177,190,197],"(+/-":[76],"0.2":[77],"Hz)":[78,96],"are":[79,97,181],"caused":[80,191],"respiratory":[82],"induced":[83],"mediated":[88],"vagus":[91],"nerve.":[92],"Low-frequency":[93],"(0.06-0.12":[95],"related":[98],"baroreflex":[101,214],"control":[102,215],"activity":[105],"rate.":[108],"In":[109],"our":[110,167],"study,":[111],"even":[112],"partial":[113],"decreased":[121,151],"power":[123],"high":[126,175],"low":[128],"frequency":[129,144,176],"fluctuations.":[132],"There":[133],"were":[134],"no":[135],"significant":[136],"changes":[137],"either":[143],"range.":[145],"Sympathetic":[146],"only":[152],"low-frequency":[153],"both":[156,202],"pressure.":[161],"From":[162],"a":[163],"model":[165],"experimental":[168],"results":[169],"we":[170],"support":[171],"view":[173],"that":[174,195],"due":[182],"vagal":[185],"respiration":[193],"around":[198],"0.1":[199],"Hz":[200],"have":[208],"their":[209],"origin":[210],"loop":[216],"activity.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
