{"id":"https://openalex.org/W49401896","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","title":"Use of Mesenchymal Stem Cells in the Regulation of Inflammation: Novel Concept for Future Therapies in the Lung","display_name":"Use of Mesenchymal Stem Cells in the Regulation of Inflammation: Novel Concept for Future Therapies in the Lung","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W49401896","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","mag":"49401896"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.1065.27","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042527382","display_name":"Mauricio Rojas","orcid":"https://orcid.org/0000-0002-7791-9328","observed_orcids":["https://orcid.org/0000-0002-7791-9328"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mauricio Rojas","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624030","display_name":"Jianguo Xu","orcid":"https://orcid.org/0000-0002-5053-8525","observed_orcids":["https://orcid.org/0000-0002-5053-8525"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianguo Xu","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024425772","display_name":"Smita Swaminathan Iyer","orcid":"https://orcid.org/0000-0002-8918-7005","observed_orcids":["https://orcid.org/0000-0002-8918-7005"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smita Iyer","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077444561","display_name":"David C. Neujahr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Neujahr","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061640269","display_name":"Kenneth L. Brigham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Brigham","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087409511","display_name":"Ana Lucia Mora","orcid":"https://orcid.org/0000-0003-1653-8318","observed_orcids":["https://orcid.org/0000-0003-1653-8318"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana L Mora","raw_affiliation_strings":["Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Division of Pulmonary Allergy and Critical Care Emory University Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00350327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endotoxin-induced-lung-injury","display_name":"endotoxin-induced lung injury","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chronic-lung-inflammation","display_name":"chronic lung inflammation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/bronchiolitis-obliterans","display_name":"bronchiolitis obliterans","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7429999709129333},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7926503419876099},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7763370275497437},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7053390741348267},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6747844219207764},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5525816679000854},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.526313066482544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5237755179405212},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.4726777672767639},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4401693642139435},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.43154817819595337},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.42736801505088806},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2654319405555725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1569376289844513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10468977689743042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.1065.27","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1065.27","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000584719","https://openalex.org/W3017217696","https://openalex.org/W2381828543","https://openalex.org/W4285310569","https://openalex.org/W2118165038","https://openalex.org/W4390270128","https://openalex.org/W3031595042","https://openalex.org/W1967824323","https://openalex.org/W2147156629","https://openalex.org/W2889126534"],"abstract_inverted_index":{"Bone":[0],"marrow\u2010derived":[1],"mesenchymal":[2],"stem":[3],"cells":[4,28,117,218,246],"(BMDMSCs)":[5],"appear":[6],"to":[7,52,110,191,243,248],"be":[8],"important":[9],"in":[10,25,69,74,92],"the":[11,23,48,54,83,93,104,108,119,128,169,178,184,193,201,211,217,223,241,258,261],"prevention":[12],"of":[13,50,85,98,113,121,130,140,157,166,175,181,186,196,207,210,213,260],"lung":[14,62],"damage":[15],"after":[16,168],"acute":[17,58],"and":[18,40,59,76,90,118,198,232,247,254],"chronic":[19,60,141,176],"inflammatory":[20,61,262],"process;":[21],"however":[22],"mechanisms":[24],"which":[26],"these":[27,99],"protect":[29],"are":[30],"unknown.":[31],"Using":[32],"an":[33],"endotoxin\u2010induced":[34],"Acute":[35],"Lung":[36,144],"Injury":[37],"(ALI)":[38],"model":[39,45,73,139,174],"a":[41,138,147,204],"heterotopic":[42,134],"trachea":[43,135],"transplant":[44,136,142],"we":[46,66,126,228],"demonstrate":[47,192,222],"ability":[49,109],"BMDMSC":[51,68,81,182,208,227,239],"regulate":[53],"immune":[55,263],"response":[56],"during":[57,133],"diseases":[63],"respectively.":[64],"First,":[65],"administrated":[67],"endotoxin":[70],"induced":[71],"ALI":[72],"mice":[75,202,214],"pigs.":[77],"We":[78,188],"observed":[79,105],"that":[80,238,256],"suppressed":[82],"upregulation":[84],"pro\u2010inflammatory":[86],"cytokines":[87],"preventing":[88],"inflammation":[89,197],"edema":[91],"lung.":[94],"The":[95],"clinical":[96],"relevance":[97],"studies":[100,236],"is":[101,146],"shown":[102],"by":[103,226],"association":[106],"between":[107],"induce":[111,244],"mobilization":[112],"bone":[114],"marrow":[115],"derived":[116],"survival":[120],"patients":[122],"with":[123],"ALI.":[124],"Second,":[125],"studied":[127],"effect":[129],"BMDSC":[131],"administration":[132,180],"as":[137],"rejection.":[143],"transplantation":[145],"viable":[148],"treatment":[149],"option":[150],"for":[151,164],"end\u2010stage":[152],"pulmonary":[153],"diseases,":[154],"but":[155],"development":[156,185],"obliterative":[158],"bronchiolitis":[159],"(OB),":[160],"reduces":[161],"survival,":[162],"accounting":[163],"30%":[165],"deaths":[167],"third":[170],"year.":[171],"In":[172],"this":[173],"inflammation,":[177],"systemic":[179],"prevents":[183],"OB.":[187],"were":[189,219],"able":[190],"total":[194],"inhibition":[195],"fibrosis":[199],"when":[200],"received":[203],"single":[205],"dose":[206],"independent":[209],"strain":[212],"from":[215],"where":[216],"obtained.":[220],"To":[221],"mechanism":[224],"used":[225],"realize":[229],"co\u2010culture":[230],"experiments":[231],"affimetrix":[233],"analysis.":[234],"These":[235],"reveled":[237],"have":[240],"capacity":[242],"T\u2010regulatory":[245],"produce":[249],"soluble":[250],"factors":[251],"like":[252],"TGF\u03b2":[253],"sIL1\u2010R":[255],"mediate":[257],"suppression":[259],"response.":[264]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
