{"id":"https://openalex.org/W493655","doi":"https://doi.org/10.2144/02321dd03","title":"Efficacy of an Amphipathic Oligopeptide to Shuttle and Release a cis -Acting DNA Decoy into Human Cells","display_name":"Efficacy of an Amphipathic Oligopeptide to Shuttle and Release a cis -Acting DNA Decoy into Human Cells","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W493655","doi":"https://doi.org/10.2144/02321dd03","mag":"493655","pmid":"https://pubmed.ncbi.nlm.nih.gov/11808690"},"language":"en","primary_location":{"id":"doi:10.2144/02321dd03","doi":"https://doi.org/10.2144/02321dd03","is_oa":true,"landing_page_url":"https://doi.org/10.2144/02321dd03","pdf_url":"https://www.future-science.com/doi/pdf/10.2144/02321dd03","source":{"id":"https://openalex.org/S79990748","display_name":"BioTechniques","issn_l":"0736-6205","issn":["0736-6205","1940-9818"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioTechniques","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.future-science.com/doi/pdf/10.2144/02321dd03","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085271923","display_name":"Lorenzo Citti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Citti","raw_affiliation_strings":["Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018078852","display_name":"Paolo Rovero","orcid":"https://orcid.org/0000-0001-9577-5228","observed_orcids":["https://orcid.org/0000-0001-9577-5228"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Rovero","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Salerno, Salerno Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Salerno, Salerno Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047428131","display_name":"Maria Giovanna Colombo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M.G. Colombo","raw_affiliation_strings":["Istituto di Fisiologia Clinica, CNR, Pisa, Italy","Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Fisiologia Clinica, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076"]},{"raw_affiliation_string":"Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109285840","display_name":"L. Mariani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Mariani","raw_affiliation_strings":["Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017664557","display_name":"Laura Poliseno","orcid":"https://orcid.org/0000-0001-6557-955X","observed_orcids":["https://orcid.org/0000-0001-6557-955X"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Poliseno","raw_affiliation_strings":["Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091162026","display_name":"Gabriella Rainaldi","orcid":"https://orcid.org/0000-0001-7213-6853","observed_orcids":["https://orcid.org/0000-0001-7213-6853"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Rainaldi","raw_affiliation_strings":["Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1415,"currency":"USD","value_usd":1415},"apc_paid":{"value":1415,"currency":"USD","value_usd":1415},"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":4.562e-05,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"32","issue":"1","first_page":"172","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mgmt-gene","display_name":"MGMT gene","score":0.6179999709129333},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.6809999942779541},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.6859999895095825},{"id":"https://openalex.org/keywords/oligonucleotide-delivery","display_name":"oligonucleotide delivery","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mcf-10a-cells","display_name":"MCF10A cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7009999752044678},{"id":"https://openalex.org/keywords/peptide-dna-complexes","display_name":"peptide-DNA complexes","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7965788245201111},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7484106421470642},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.7295259237289429},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.617236852645874},{"id":"https://openalex.org/C2779179475","wikidata":"https://www.wikidata.org/wiki/Q3545649","display_name":"Decoy","level":3,"score":0.600671112537384},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5588200688362122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5201797485351562},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4604940712451935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3718082010746002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3666747808456421},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3192594051361084},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.09176033735275269},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2144/02321dd03","doi":"https://doi.org/10.2144/02321dd03","is_oa":true,"landing_page_url":"https://doi.org/10.2144/02321dd03","pdf_url":"https://www.future-science.com/doi/pdf/10.2144/02321dd03","source":{"id":"https://openalex.org/S79990748","display_name":"BioTechniques","issn_l":"0736-6205","issn":["0736-6205","1940-9818"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioTechniques","raw_type":"journal-article"},{"id":"pmid:11808690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11808690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioTechniques","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6c6669032b5e4e5b9a26d1d3513273fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6c6669032b5e4e5b9a26d1d3513273fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioTechniques, Vol 32, Iss 1, Pp 172-177 (2002)","raw_type":"article"},{"id":"pmh:oai:flore.unifi.it:2158/5443","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/5443","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2144/02321dd03","doi":"https://doi.org/10.2144/02321dd03","is_oa":true,"landing_page_url":"https://doi.org/10.2144/02321dd03","pdf_url":"https://www.future-science.com/doi/pdf/10.2144/02321dd03","source":{"id":"https://openalex.org/S79990748","display_name":"BioTechniques","issn_l":"0736-6205","issn":["0736-6205","1940-9818"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioTechniques","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W493655.pdf","grobid_xml":"https://content.openalex.org/works/W493655.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1662819364","https://openalex.org/W1907545229","https://openalex.org/W1990557525","https://openalex.org/W1998956812","https://openalex.org/W2030118774","https://openalex.org/W2038720675","https://openalex.org/W2053499004","https://openalex.org/W2074198716","https://openalex.org/W2082301173","https://openalex.org/W2086274688","https://openalex.org/W2087917270","https://openalex.org/W2099871857"],"related_works":["https://openalex.org/W2080684604","https://openalex.org/W2108224709","https://openalex.org/W1978211790","https://openalex.org/W1995256659","https://openalex.org/W2069000639","https://openalex.org/W2147842059","https://openalex.org/W2002591579","https://openalex.org/W4233431278","https://openalex.org/W2153805912","https://openalex.org/W2009692654"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,27,31,49,63,72,79,81,92,99,105,109,113,120,133],"ability":[3],"of":[4,30,62,71,98,108,112,135,141],"an":[5],"amphipathic":[6,137],"oligopeptide":[7,38],"to":[8,43,88],"carry":[9],"a":[10,22,57,89,124],"synthetic":[11],"dsDNA":[12],"oligonucleotide":[13,18],"inside":[14],"human":[15],"cells.":[16],"The":[17,36],"was":[19,51,102],"designed":[20],"as":[21,104,139],"decoy":[23,40],"binding":[24],"site":[25],"for":[26],"transcriptional":[28],"activator":[29],"methylguanine-DNA":[32],"methyltransferase":[33],"(MGMT)":[34],"gene.":[35],"complex":[37,122],"and":[39,48],"were":[41,66],"administered":[42],"MCF10A":[44,64,116],"exponentially":[45],"growing":[46],"cells,":[47],"uptake":[50],"monitored":[52],"by":[53],"flow":[54],"cytometry.":[55],"After":[56],"1-h":[58],"exposure,":[59],"almost":[60],"all":[61,70],"cells":[65,73,117],"fluorescent,":[67],"indicating":[68],"that":[69],"had":[74],"been":[75],"transfected.":[76],"By":[77],"increasing":[78],"time,":[80],"fluorescence":[82],"intensity":[83],"per":[84],"cell":[85],"rapidly":[86],"increased":[87],"plateau":[90],"at":[91],"8-h":[93],"time":[94],"point.":[95],"RT-PCR":[96],"analysis":[97],"MGMT":[100,128],"gene":[101],"used":[103],"molecular":[106],"readout":[107],"intracellular":[110],"activity":[111],"DNA":[114,143],"decoy.":[115],"transfected":[118],"with":[119],"oligopeptide/decoy":[121],"showed":[123],"strong":[125],"reduction":[126],"in":[127],"mRNA.":[129],"Here,":[130],"we":[131],"discuss":[132],"advantages":[134],"using":[136],"oligopeptides":[138],"carriers":[140],"short":[142],"sequences.":[144]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
