{"id":"https://openalex.org/W49138001","doi":null,"title":"Antilipopolysaccharide improves survival in primates subjected to heat stroke.","display_name":"Antilipopolysaccharide improves survival in primates subjected to heat stroke.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W49138001","mag":"49138001","pmid":"https://pubmed.ncbi.nlm.nih.gov/3427771"},"language":"en","primary_location":{"id":"pmid:3427771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3427771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103270163","display_name":"Prem Gathiram","orcid":"https://orcid.org/0000-0002-6648-8833","observed_orcids":["https://orcid.org/0000-0002-6648-8833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gathiram","raw_affiliation_strings":["Department of Physiology, University of Durban Westville, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Durban Westville, South Africa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103887772","display_name":"Matthew Wells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Wells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053490511","display_name":"John G. Brock\u2010Utne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Brock-Utne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110167413","display_name":"S L Gaffin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Gaffin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4142,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.78124497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"23","issue":"3","first_page":"157","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stroke","display_name":"heatstroke","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anti-lipopolysaccharide-antibodies","display_name":"anti-lipopolysaccharide antibodies","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hyperimmune-plasma","display_name":"hyperimmune plasma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.6579999923706055},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6200000047683716},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.7229999899864197},{"id":"https://openalex.org/keywords/primates","display_name":"primates","score":0.5899999737739563},{"id":"https://openalex.org/keywords/monkeys","display_name":"monkeys","score":0.6919999718666077},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C3019193636","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectal temperature","level":2,"score":0.7616046667098999},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5318217873573303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5114468336105347},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4639517664909363},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.4426631033420563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4208187758922577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4149683117866516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33541440963745117},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33278775215148926},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006359","descriptor_name":"Heat Exhaustion","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3427771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3427771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Journal Article"},{"id":"mag:49138001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3427771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W135836199","https://openalex.org/W185497621","https://openalex.org/W66654216","https://openalex.org/W74438234","https://openalex.org/W2012243903","https://openalex.org/W1775507621","https://openalex.org/W2332619513","https://openalex.org/W2065183302","https://openalex.org/W2027847060","https://openalex.org/W2400228778"],"abstract_inverted_index":{"Recent":[0],"investigations":[1],"have":[2,249],"suggested":[3],"that":[4,116,246,257],"endotoxins":[5],"or":[6,144],"lipopolysaccharides":[7],"(LPS)":[8],"may":[9,248],"play":[10],"a":[11,46,66,160,173,195,232,250],"role":[12,251],"in":[13,37,147,221,228,252],"heat":[14,35,253,272],"stroke":[15,36,254],"pathophysiology.":[16],"In":[17],"this":[18],"study":[19],"we":[20],"wish":[21],"to":[22,45,58,130,159,265],"investigate":[23],"whether":[24],"prophylactic":[25,67,174,258],"administration":[26],"of":[27,33,49,70,86,99,163,177,271],"anti-LPS":[28,72,179,192,261],"hyperimmune":[29],"plasma":[30,121,148,193,218,235],"improves":[31],"survival":[32,198],"experimental":[34,92,132],"primates.":[38],"Eleven":[39],"monkeys":[40,93,154,224],"were":[41,157,189],"anesthetised":[42],"and":[43,55,134,256],"heat-stressed":[44,158],"rectal":[47,161],"temperature":[48,162],"43.5":[50],"degrees":[51,165],"C":[52],"(group":[53,155],"A)":[54],"then":[56],"allowed":[57],"recover":[59],"at":[60],"room":[61],"temperature.":[62],"Five":[63],"had":[64,118,171,194],"received":[65,81,172],"i.v.":[68,84,175],"dose":[69,85,176],"equine":[71,88,178],"(experimental":[73],"group),":[74],"while":[75,95],"the":[76,91,100,113,131,135,186,205,217,222,229,269],"other":[77],"six":[78,101],"(control":[79],"group)":[80],"an":[82],"equivalent":[83],"nonimmune":[87],"plasma.":[89,180],"All":[90,112],"survived,":[94],"only":[96],"one":[97],"out":[98],"controls":[102],"survived":[103],"(chi":[104],"2":[105],"=":[106],"4.65,":[107],"p":[108],"less":[109,125,213,241],"than":[110,126,204,214,242],"0.025).":[111],"control":[114],"animals":[115,184],"succumbed":[117],"significantly":[119,196,233],"elevated":[120,234],"LPS":[122,149,219,236,247],"levels":[123,220],"(p":[124,212,240],"0.05)":[127],"as":[128],"compared":[129],"group":[133,207],"single":[136],"surviving":[137],"control.":[138],"The":[139],"latter":[140],"showed":[141],"very":[142],"little":[143],"no":[145],"change":[146],"levels.":[150],"A":[151],"further":[152],"eight":[153,183],"B)":[156],"43.8":[164],"C.":[166],"Of":[167],"these":[168],"eight,":[169],"four":[170,187],"Although":[181],"all":[182],"died,":[185],"which":[188],"pretreated":[190],"with":[191,260],"longer":[197],"time":[199],"(427.5":[200],"+/-":[201,209],"61.39":[202],"min)":[203,211],"untreated":[206,230],"(81.25":[208],"33.94":[210],"0.05).":[215],"Furthermore,":[216],"treated":[223],"remained":[225],"unchanged":[226],"whereas":[227],"group,":[231],"level":[237],"was":[238],"noticed":[239],"0.005).":[243],"We":[244],"conclude":[245],"pathophysiology":[255],"treatment":[259],"antibodies":[262],"would":[263],"seem":[264],"offer":[266],"protection":[267],"against":[268],"effects":[270],"stress.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
