{"id":"https://openalex.org/W49108541","doi":null,"title":"Assessment of pathologic prognostic factors in breast core needle biopsies.","display_name":"Assessment of pathologic prognostic factors in breast core needle biopsies.","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W49108541","mag":"49108541","pmid":"https://pubmed.ncbi.nlm.nih.gov/10530557"},"language":"en","primary_location":{"id":"pmid:10530557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10530557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013366075","display_name":"Sheida Sharifi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sharifi","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113541105","display_name":"Mary Kay Peterson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M K Peterson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034078685","display_name":"Janet K. Baum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Baum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109225227","display_name":"Syed Arsalan Raza","orcid":"https://orcid.org/0000-0002-8706-8475","observed_orcids":["https://orcid.org/0000-0002-8706-8475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Raza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109117583","display_name":"Stuart J. Schnitt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Schnitt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7299,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.8333026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"10","first_page":"941","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7559999823570251},{"id":"https://openalex.org/keywords/core-needle-biopsy","display_name":"core needle biopsy","score":0.996999979019165},{"id":"https://openalex.org/keywords/histologic-grade","display_name":"histologic grade","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.6570000052452087},{"id":"https://openalex.org/keywords/lymphatic-vessel-invasion","display_name":"lymphatic vessel invasion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/extensive-intraductal-component","display_name":"extensive intraductal component","score":0.9829999804496765},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.8629999756813049},{"id":"https://openalex.org/keywords/invasive-lobular-carcinoma","display_name":"invasive lobular carcinoma","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8104422688484192},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.7330618500709534},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.6529103517532349},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6119059324264526},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5745446681976318},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5648130774497986},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.5299661755561829},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47396108508110046},{"id":"https://openalex.org/C2776372563","wikidata":"https://www.wikidata.org/wiki/Q929221","display_name":"Invasive lobular carcinoma","level":5,"score":0.45385512709617615},{"id":"https://openalex.org/C194495517","wikidata":"https://www.wikidata.org/wiki/Q7646222","display_name":"Surgical pathology","level":2,"score":0.42228615283966064},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36870819330215454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1420610249042511},{"id":"https://openalex.org/C3020375857","wikidata":"https://www.wikidata.org/wiki/Q1671685","display_name":"Invasive ductal carcinoma","level":4,"score":0.09369015693664551},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018275","descriptor_name":"Carcinoma, Lobular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10530557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10530557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"},{"id":"mag:49108541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10530557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009339596","https://openalex.org/W2099335067","https://openalex.org/W4389586694","https://openalex.org/W2127730327","https://openalex.org/W2465688720","https://openalex.org/W1973765429","https://openalex.org/W4387942545","https://openalex.org/W1985413232","https://openalex.org/W2049820079","https://openalex.org/W2003316136"],"abstract_inverted_index":{"BACKGROUND:":[0],"Core":[1],"needle":[2],"biopsies":[3],"(CNB)":[4],"are":[5,21],"being":[6],"used":[7],"increasingly":[8],"as":[9,25,29,270],"the":[10,36,96,106,135,171,210,214,219,223,241,247,253,262,300],"initial":[11],"diagnostic":[12],"procedure":[13],"in":[14,23,43,51,76,147,179,190,198,205,218,222,225,230,246,285,292,299,307],"women":[15,63],"with":[16,64,122,143,244,258],"breast":[17,66],"cancer.":[18,67],"Many":[19],"clinicians":[20],"interested":[22],"obtaining":[24],"much":[26],"prognostic":[27,41],"information":[28],"possible":[30],"from":[31,61,69],"these":[32],"limited":[33],"specimens.":[34,137],"However,":[35,232],"accuracy":[37],"of":[38,98,134,181,192,207,240,302],"assessing":[39],"pathologic":[40,172],"factors":[42],"core":[44],"biopsy":[45],"material":[46],"has":[47],"not":[48],"been":[49],"studied":[50,55],"detail.":[52],"DESIGN:":[53],"We":[54],"CNB":[56,70,141,161,178,189,202,224,284,296,325],"and":[57,71,80,95,124,127,162,203,228,297,322],"subsequent":[58],"excision":[59,72,136,146,163,220,248,263,298],"specimens":[60,73,164],"79":[62,107],"invasive":[65,112,116,120],"Slides":[68],"were":[74,110,235,268],"reviewed":[75],"a":[77,154,308],"blinded":[78],"fashion":[79],"each":[81],"was":[82,153,175,186,196,216,290,305],"assessed":[83],"for":[84],"histologic":[85,89,199,293],"type,":[86],"tumor":[87,158,317],"size,":[88],"grade,":[90],"lymphatic":[91],"vessel":[92],"invasion":[93],"(LVI),":[94],"presence":[97],"an":[99,259,272],"extensive":[100],"intraductal":[101],"component":[102],"(EIC).":[103],"RESULTS:":[104],"Among":[105,209,255],"cancers,":[108],"there":[109,152,289],"58":[111],"ductal":[113,123],"carcinomas,":[114,118,130],"six":[115],"lobular":[117,125],"13":[119,226],"carcinomas":[121],"features":[126],"two":[128],"tubular":[129],"based":[131],"on":[132,140,145,160,177,188,252,261,274,283,324],"examination":[133],"Histologic":[138,277],"type":[139,278],"correlated":[142],"that":[144],"64":[148],"cases":[149,227,257],"(81%).":[150],"Although":[151],"significant":[155],"correlation":[156],"between":[157,201,295],"size":[159,318],"(r2":[165],"=":[166,169],"0.30,":[167],"P":[168],"0.01),":[170],"T":[173,184],"stage":[174],"underestimated":[176,187],"79%":[180],"cases.":[182,208,287],"Furthermore,":[183],"substage":[185],"71%":[191],"T1":[193],"lesions.":[194],"There":[195],"concordance":[197,291],"grade":[200,215,294,304],"excisions":[204],"75%":[206],"20":[211],"discordant":[212,306],"cases,":[213,303],"higher":[217],"than":[221],"lower":[229],"seven.":[231],"all":[233],"discrepancies":[234],"within":[236],"one":[237],"grade.":[238],"None":[239],"17":[242],"cancers":[243],"LVI":[245,251],"specimen":[249],"showed":[250],"CNB.":[254,275],"14":[256],"EIC":[260,273,323],"specimen,":[264],"only":[265],"four":[266],"(29%)":[267],"scored":[269],"having":[271],"CONCLUSION:":[276],"can":[279],"be":[280],"accurately":[281,315],"determined":[282],"most":[286],"While":[288],"majority":[301],"substantial":[309],"minority":[310],"(25%).":[311],"The":[312],"ability":[313],"to":[314],"determine":[316],"(pathologic":[319],"T-stage),":[320],"LVI,":[321],"is":[326],"severely":[327],"limited.":[328]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}