{"id":"https://openalex.org/W48855981","doi":null,"title":"Eisenmenger syndrome in the adult--experience with new drugs for the treatment of pulmonary hypertension.","display_name":"Eisenmenger syndrome in the adult--experience with new drugs for the treatment of pulmonary hypertension.","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W48855981","mag":"48855981","pmid":"https://pubmed.ncbi.nlm.nih.gov/15929625"},"language":"en","primary_location":{"id":"pmid:15929625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15929625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049106452","display_name":"Ana Figueiredo Agapito","orcid":"https://orcid.org/0000-0002-5673-9459","observed_orcids":["https://orcid.org/0000-0002-5673-9459"]},"institutions":[{"id":"https://openalex.org/I4210146236","display_name":"Hospital de Santa Marta","ror":"https://ror.org/05cvd2j85","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157","https://openalex.org/I4210146236"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Figueiredo Agapito","raw_affiliation_strings":["Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Lisboa, Portugal. afag@netcabo.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Cardiologia, Hospital de Santa Marta, Lisboa, Portugal. afag@netcabo.pt","institution_ids":["https://openalex.org/I4210146236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015786554","display_name":"L\u00eddia de Sousa","orcid":"https://orcid.org/0000-0002-8507-1443","observed_orcids":["https://orcid.org/0000-0002-8507-1443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00eddia Sousa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660876","display_name":"Jos\u00e9 Alberto Oliveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Alberto Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108475482","display_name":"Joana Feliciano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joana Feliciano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071445356","display_name":"Duarte Cacela","orcid":"https://orcid.org/0009-0007-6597-5633","observed_orcids":["https://orcid.org/0009-0007-6597-5633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duarte Cacela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003666196","display_name":"Jorge Quininha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Quininha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6881,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74692212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"24","issue":"3","first_page":"421","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eisenmenger-syndrome","display_name":"Eisenmenger syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9829999804496765},{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.8389999866485596},{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bosentan","display_name":"bosentan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/right-to-left-shunt","display_name":"right-to-left shunt","score":0.7549999952316284},{"id":"https://openalex.org/keywords/atrial-septal-defect","display_name":"atrial septal defect","score":0.8820000290870667},{"id":"https://openalex.org/keywords/patent-ductus-arteriosus","display_name":"patent ductus arteriosus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ventricular-septal-defect","display_name":"ventricular septal defect","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myocardial-performance-index","display_name":"myocardial performance index","score":0.6740000247955322},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pulmonary-vasodilator-therapy","display_name":"pulmonary vasodilator therapy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/adult-congenital-heart-disease","display_name":"adult congenital heart disease","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8725425004959106},{"id":"https://openalex.org/C2781109936","wikidata":"https://www.wikidata.org/wiki/Q419769","display_name":"Bosentan","level":4,"score":0.8373540043830872},{"id":"https://openalex.org/C2779249879","wikidata":"https://www.wikidata.org/wiki/Q572695","display_name":"Eisenmenger syndrome","level":3,"score":0.816219687461853},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.782811164855957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7276744842529297},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7088355422019958},{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.6281911134719849},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5893173217773438},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.543079137802124},{"id":"https://openalex.org/C2781236024","wikidata":"https://www.wikidata.org/wiki/Q1163923","display_name":"Ductus arteriosus","level":2,"score":0.5023460388183594},{"id":"https://openalex.org/C2780346441","wikidata":"https://www.wikidata.org/wiki/Q55609890","display_name":"Doppler echocardiography","level":4,"score":0.5005638599395752},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.413333535194397},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.12629932165145874},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077300","descriptor_name":"Bosentan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004541","descriptor_name":"Eisenmenger Complex","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15929625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15929625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},{"id":"mag:48855981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15929625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2315812492","https://openalex.org/W2924601775","https://openalex.org/W73998748","https://openalex.org/W2946689754","https://openalex.org/W9878812","https://openalex.org/W2094601195","https://openalex.org/W3126522029","https://openalex.org/W2057769789","https://openalex.org/W2594461616","https://openalex.org/W2036514129"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,18,151,170,327],"last":[2],"few":[3],"years":[4,95],"have":[5],"seen":[6],"significant":[7],"progress":[8],"in":[9,27,51,55,79,137,167,201,207,212,267,273,314,332,357],"the":[10,38,180,218,233,244,248,281,284,296,307,315,341,351],"treatment":[11,185,197,328],"of":[12,20,88,153,343],"advanced":[13],"pulmonary":[14,66],"arterial":[15],"hypertension":[16],"(PAH).":[17],"efficacy":[19],"new":[21,75,352],"drugs":[22,49,76,354],"has":[23],"been":[24],"proved":[25],"mainly":[26],"idiopathic":[28],"PAH":[29,31,61,78,356],"or":[30,54,118],"associated":[32,134],"with":[33,60,74,81,101,128,135,158,210,350,363],"connective":[34],"tissue":[35],"diseases.":[36],"As":[37],"pathophysiologic":[39],"patterns":[40],"are":[41,265],"similar,":[42],"it":[43],"is":[44,272],"reasonable":[45],"to":[46,63,93,105,190,226,238,252,289,301,321],"use":[47],"these":[48],"also":[50],"Eisenmenger":[52,82,102,358],"syndrome":[53,103,359],"other":[56],"congenital":[57],"heart":[58],"defects":[59],"related":[62],"initial":[64,348],"high":[65],"flow.":[67],"OBJECTIVES:":[68],"To":[69],"evaluate":[70],"our":[71,347],"early":[72],"experience":[73,349],"for":[77,355],"patients":[80,171,199,260,344],"syndrome.":[83],"METHODS:":[84],"A":[85],"retrospective":[86],"study":[87,166],"five":[89],"patients,":[90],"aged":[91],"28":[92],"51":[94],"(39.6":[96],"+/-":[97,194,230,241,256,293,304,325],"9.94),":[98],"four":[99],"female,":[100],"due":[104],"atrial":[106],"septal":[107,120],"defect":[108,121],"(n":[109,115,122,130,142],"=":[110,116,123,131,143],"2),":[111],"patent":[112],"ductus":[113],"arteriosus":[114],"2)":[117],"ventricular":[119],"1),":[124,144],"who":[125],"began":[126],"therapy":[127],"iloprost":[129],"4,":[132],"later":[133],"sildenafil":[136],"one":[138,277],"patient)":[139],"and":[140,148,155,179,186,205,232,276,295,365,368],"bosentan":[141],"between":[145],"April":[146],"2001":[147],"May":[149],"2003.":[150],"existence":[152],"severe":[154],"fixed":[156],"PAH,":[157],"predominant":[159],"right-to-left":[160],"shunt,":[161],"was":[162,224,236,250,287,299,318,329,345],"confirmed":[163],"by":[164,174],"hemodynamic":[165],"all":[168,333],"cases.":[169],"were":[172,200],"evaluated":[173],"clinical":[175,364],"examination,":[176],"Doppler":[177,216],"echocardiography":[178,217],"six-minute":[181,245,308],"walk":[182,246,309],"test":[183,247,310],"before":[184],"throughout":[187],"follow-up":[188],"(9":[189],"34":[191],"months,":[192],"19.8":[193],"9.04).":[195],"Before":[196],"two":[198],"NYHA":[202],"class":[203,208,213,268,274],"III":[204,209],"three":[206,264],"periods":[211],"IV.":[214],"By":[215],"right":[219],"ventricle-right":[220],"atrium":[221],"(RV-RA)":[222],"gradient":[223,286],"74":[225],"111":[227],"mmHg":[228,291],"(90.6":[229],"15.73)":[231],"Tei":[234,297],"index":[235,298],"0.53":[237],"2.05":[239],"(1.13":[240],"0.62).":[242],"In":[243,306],"distance":[249,316],"214":[251],"500":[253],"meters":[254,323],"(296.8":[255],"115.27).":[257],"RESULTS:":[258],"All":[259],"improved":[261],"clinically,":[262],"though":[263],"still":[266],"III.":[269],"One":[270],"patient":[271,278],"II":[275],"died.":[279],"At":[280],"latest":[282],"evaluation":[283],"RV-RA":[285],"60":[288],"112":[290],"(84.8":[292],"19.11)":[294],"0.5":[300],"1.33":[302],"(0.85":[303],"80.32).":[305],"a":[311],"net":[312],"increase":[313],"covered":[317],"evident:":[319],"376":[320],"520":[322],"(420":[324],"57.89).":[326],"well":[330],"tolerated":[331],"cases,":[334],"without":[335,369],"serious":[336],"adverse":[337,370],"effects.":[338,371],"CONCLUSIONS:":[339],"Though":[340],"number":[342],"small,":[346],"specific":[353],"showed":[360],"promising":[361],"results,":[362],"functional":[366],"improvement":[367]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
