{"id":"https://openalex.org/W48765218","doi":null,"title":"Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats.","display_name":"Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats.","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W48765218","mag":"48765218","pmid":"https://pubmed.ncbi.nlm.nih.gov/10898096"},"language":"en","primary_location":{"id":"pmid:10898096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10898096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085600620","display_name":"Jerzy Jochem","orcid":"https://orcid.org/0000-0001-7403-2177","observed_orcids":["https://orcid.org/0000-0001-7403-2177"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"J Jochem","raw_affiliation_strings":["Department of Physiology, Silesian Medical University, Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Silesian Medical University, Zabrze, Poland","institution_ids":["https://openalex.org/I166182418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085600620"],"corresponding_institution_ids":["https://openalex.org/I166182418"],"apc_list":null,"apc_paid":null,"fwci":2.099,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.8563469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"2","first_page":"229","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.09640000015497208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.984000027179718},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8090000152587891},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.7609999775886536},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5799999833106995},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.9169999957084656},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6209999918937683},{"id":"https://openalex.org/keywords/chlorpheniramine","display_name":"chlorpheniramine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ranitidine","display_name":"ranitidine","score":0.8820000290870667},{"id":"https://openalex.org/keywords/thioperamide","display_name":"thioperamide","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8589097261428833},{"id":"https://openalex.org/C2778997900","wikidata":"https://www.wikidata.org/wiki/Q7784686","display_name":"Thioperamide","level":5,"score":0.8558937311172485},{"id":"https://openalex.org/C2777445857","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine","level":2,"score":0.7035987973213196},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6253657341003418},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.595901370048523},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.524820864200592},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5237705111503601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5207343101501465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5054380893707275},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5034586787223816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4685068428516388},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.46274852752685547},{"id":"https://openalex.org/C159545944","wikidata":"https://www.wikidata.org/wiki/Q424228","display_name":"Histamine receptor","level":4,"score":0.459789514541626},{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.42317235469818115},{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.4169186055660248},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3392598032951355},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3374348282814026}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10898096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10898096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:48765218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10898096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170089218","https://openalex.org/W2015210497","https://openalex.org/W2036410356","https://openalex.org/W1990867829","https://openalex.org/W2134175618","https://openalex.org/W2165694706","https://openalex.org/W211370073","https://openalex.org/W2049115053","https://openalex.org/W2396972109","https://openalex.org/W4231820601"],"abstract_inverted_index":{"The":[0,22,82],"study":[1],"was":[2,100],"designed":[3],"to":[4,96],"determine":[5],"the":[6,33,97,116,153,162,179],"cardiovascular":[7],"effects":[8],"of":[9,18,24,27,35,47,76,167],"histamine":[10,48,89,141,154,175,184],"administered":[11,176],"intracerebroventricularly":[12],"(icv)":[13],"in":[14,32,60,84,91,94,118],"a":[15,50,73],"rat":[16],"model":[17],"volume-controlled":[19],"haemorrhagic":[20,180],"shock.":[21],"withdrawal":[23],"approximately":[25],"50%":[26],"total":[28],"blood":[29],"volume":[30],"resulted":[31],"death":[34],"all":[36],"control":[37],"saline":[38],"icv":[39,177],"treated":[40],"animals":[41,99],"within":[42],"30":[43],"min.":[44],"Icv":[45],"injection":[46],"produced":[49,125],"prompt":[51],"dose-dependent":[52],"(0.1-100":[53],"nmol)":[54,58],"and":[55,68,86,102,122,183],"long-lasting":[56],"(10-100":[57],"increase":[59,83,117],"mean":[61],"arterial":[62],"pressure":[63,66],"(MAP),":[64],"pulse":[65],"(PP)":[67],"heart":[69],"rate":[70,124],"(HR),":[71],"with":[72,107,165],"100%":[74],"survival":[75,123,168],"2h":[77],"after":[78,88],"treatment":[79],"(100":[80],"nmol).":[81],"MAP":[85],"HR":[87,121],"administration":[90],"bled":[92],"rats":[93],"comparison":[95],"normovolaemic":[98],"2.7-3.3-":[101],"1.3-3.6-fold":[103],"higher,":[104],"respectively.":[105],"Pretreatment":[106],"chlorpheniramine":[108,129],"(50":[109,137,146],"nmol":[110,138,147],"icv),":[111,139,148],"H1":[112,185],"receptor":[113,142,150],"antagonist,":[114,143],"inhibited":[115],"MAP,":[119],"PP,":[120],"by":[126],"histamine,":[127],"while":[128],"given":[130,158],"alone":[131],"had":[132],"no":[133],"effect.":[134],"Neither":[135],"ranitidine":[136],"H2":[140],"nor":[144],"thioperamide":[145],"H3":[149],"blocker,":[151],"influenced":[152],"action,":[155],"however,":[156],"when":[157],"alone,":[159],"both":[160],"evoked":[161],"pressor":[163],"effect":[164],"elongation":[166],"time.":[169],"It":[170],"can":[171],"be":[172],"concluded":[173],"that":[174],"reverses":[178],"shock":[181],"conditions,":[182],"receptors":[186],"are":[187],"involved.":[188]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
