{"id":"https://openalex.org/W48736744","doi":null,"title":"Clinical biomarkers in colorectal cancer.","display_name":"Clinical biomarkers in colorectal cancer.","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W48736744","mag":"48736744","pmid":"https://pubmed.ncbi.nlm.nih.gov/24893280"},"language":"en","primary_location":{"id":"pmid:24893280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24893280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010668711","display_name":"Van Karlyle Morris","orcid":"https://orcid.org/0000-0002-4911-2252","observed_orcids":["https://orcid.org/0000-0002-4911-2252"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Van Morris","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006348751","display_name":"Scott Kopetz","orcid":"https://orcid.org/0000-0001-9647-3416","observed_orcids":["https://orcid.org/0000-0001-9647-3416"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Kopetz","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.4741,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65886944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"12","first_page":"768","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/clinical-biomarkers","display_name":"clinical biomarkers","score":0.8980000019073486},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.5450000166893005},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520425200462341},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8842861652374268},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5643181800842285},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5511267185211182},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5032917857170105},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4480212926864624},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.44040441513061523},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.4328121840953827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3950929343700409},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3632321059703827},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36114931106567383},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.06555831432342529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24893280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24893280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},{"id":"mag:48736744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24893280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W1554963423","https://openalex.org/W1585517331","https://openalex.org/W1592610846","https://openalex.org/W1637251086","https://openalex.org/W1769344090","https://openalex.org/W1827289386","https://openalex.org/W1845706120","https://openalex.org/W1888056807","https://openalex.org/W1935492807","https://openalex.org/W1966607585","https://openalex.org/W1969730641","https://openalex.org/W1974365898","https://openalex.org/W1976738458","https://openalex.org/W1976786479","https://openalex.org/W1979027806","https://openalex.org/W1982972087","https://openalex.org/W1989653345","https://openalex.org/W1992864103","https://openalex.org/W1993216157","https://openalex.org/W1995216176","https://openalex.org/W2000954296","https://openalex.org/W2007418448","https://openalex.org/W2010053675","https://openalex.org/W2011288277","https://openalex.org/W2014881369","https://openalex.org/W2015527895","https://openalex.org/W2016791396","https://openalex.org/W2017347636","https://openalex.org/W2023188630","https://openalex.org/W2025221656","https://openalex.org/W2026790277","https://openalex.org/W2028220020","https://openalex.org/W2032930680","https://openalex.org/W2033236069","https://openalex.org/W2034524735","https://openalex.org/W2037952228","https://openalex.org/W2038202392","https://openalex.org/W2041343608","https://openalex.org/W2043929834","https://openalex.org/W2046787687","https://openalex.org/W2048121649","https://openalex.org/W2052228812","https://openalex.org/W2052820539","https://openalex.org/W2052982012","https://openalex.org/W2057698420","https://openalex.org/W2058511768","https://openalex.org/W2058983261","https://openalex.org/W2059987067","https://openalex.org/W2064854706","https://openalex.org/W2065059240","https://openalex.org/W2072599380","https://openalex.org/W2075158341","https://openalex.org/W2077428590","https://openalex.org/W2085633477","https://openalex.org/W2089741493","https://openalex.org/W2095201384","https://openalex.org/W2096016472","https://openalex.org/W2096371251","https://openalex.org/W2097121246","https://openalex.org/W2098043805","https://openalex.org/W2098354753","https://openalex.org/W2099536948","https://openalex.org/W2100490225","https://openalex.org/W2103414735","https://openalex.org/W2105286896","https://openalex.org/W2106789440","https://openalex.org/W2108455517","https://openalex.org/W2108958930","https://openalex.org/W2109740395","https://openalex.org/W2110682589","https://openalex.org/W2110803737","https://openalex.org/W2111807726","https://openalex.org/W2112521802","https://openalex.org/W2112565258","https://openalex.org/W2120341265","https://openalex.org/W2120490763","https://openalex.org/W2124402963","https://openalex.org/W2125229905","https://openalex.org/W2125500263","https://openalex.org/W2126122220","https://openalex.org/W2127640925","https://openalex.org/W2127951115","https://openalex.org/W2128507784","https://openalex.org/W2128542677","https://openalex.org/W2129172946","https://openalex.org/W2129469298","https://openalex.org/W2130874449","https://openalex.org/W2134142320","https://openalex.org/W2134519717","https://openalex.org/W2135800465","https://openalex.org/W2136509556","https://openalex.org/W2136781635","https://openalex.org/W2138970634","https://openalex.org/W2141172646","https://openalex.org/W2141801755","https://openalex.org/W2142564546","https://openalex.org/W2144026118","https://openalex.org/W2144425748","https://openalex.org/W2145297551","https://openalex.org/W2145310954","https://openalex.org/W2147313414","https://openalex.org/W2152490158","https://openalex.org/W2155311724","https://openalex.org/W2159187753","https://openalex.org/W2163188200","https://openalex.org/W2163792536","https://openalex.org/W2165132869","https://openalex.org/W2165389801","https://openalex.org/W2165976417","https://openalex.org/W2167539263","https://openalex.org/W2168213749","https://openalex.org/W2168280541","https://openalex.org/W2168377135","https://openalex.org/W2168600267","https://openalex.org/W2168680994","https://openalex.org/W2168770561","https://openalex.org/W2170517479","https://openalex.org/W2171235660","https://openalex.org/W2318500626","https://openalex.org/W2603968999"],"related_works":["https://openalex.org/W3030758306","https://openalex.org/W2020048154","https://openalex.org/W2403529423","https://openalex.org/W4213156115","https://openalex.org/W3030554690","https://openalex.org/W2066879544","https://openalex.org/W2920702224","https://openalex.org/W2784706285","https://openalex.org/W2917585232","https://openalex.org/W2055244682"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,27],"remains":[2,17],"the":[3,11,18,40,52,74,86,107],"second":[4],"leading":[5],"cause":[6],"of":[7,42,51,56,77,88],"cancer-related":[8],"death":[9],"in":[10,39,48,85,106],"United":[12],"States.":[13],"While":[14],"chemo-":[15],"therapy":[16],"backbone":[19],"upon":[20],"which":[21,99],"treatment":[22,87],"for":[23,66],"meta-":[24],"static":[25],"colorectal":[26,91],"is":[28],"built,":[29],"targeted":[30],"therapies":[31],"have":[32],"been":[33],"employed,":[34],"albeit":[35],"with":[36,90],"mixed":[37],"results,":[38],"management":[41],"this":[43],"disease.":[44],"Nonetheless,":[45],"increased":[46],"understanding":[47],"recent":[49],"years":[50],"complexity":[53],"and":[54,80,93],"heterogeneity":[55],"cellular":[57],"abnormalities":[58],"driving":[59],"these":[60],"tumors":[61],"has":[62],"identified":[63],"potential":[64],"targets":[65],"future":[67],"interven-":[68],"tions.":[69],"This":[70],"article":[71],"will":[72,94],"review":[73],"seminal":[75],"biomarkers":[76,98],"predic-":[78],"tive":[79],"prognostic":[81],"importance":[82],"currently":[83],"used":[84],"patients":[89],"cancer,":[92],"highlight":[95],"additional":[96],"promising":[97],"may":[100],"be":[101],"incorporated":[102],"into":[103],"clinical":[104],"practice":[105],"future.":[108]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}