{"id":"https://openalex.org/W48734947","doi":null,"title":"Laboratory infection of primates with Ascaris suum to provide a model of allergic bronchoconstriction.","display_name":"Laboratory infection of primates with Ascaris suum to provide a model of allergic bronchoconstriction.","publication_year":1983,"publication_date":"1983-11-01","ids":{"openalex":"https://openalex.org/W48734947","mag":"48734947","pmid":"https://pubmed.ncbi.nlm.nih.gov/6197218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535872"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1535872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111560203","display_name":"D. I. Pritchard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D I Pritchard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078886095","display_name":"Roy P. Eady","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Eady","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018410148","display_name":"S.T. Harper","orcid":"https://orcid.org/0009-0001-3077-2808","observed_orcids":["https://orcid.org/0009-0001-3077-2808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T Harper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109843715","display_name":"D M Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059792106","display_name":"T.S.C. Orr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T S Orr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113698803","display_name":"Ivan M. Richards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I M Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057318605","display_name":"Steve Trigg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Trigg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086654817","display_name":"Edward Wells","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Wells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0625,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89445144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"54","issue":"2","first_page":"469","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascaris-suum","display_name":"Ascaris suum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/allergic-bronchoconstriction","display_name":"allergic bronchoconstriction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.8090000152587891},{"id":"https://openalex.org/keywords/experimental-infection","display_name":"experimental infection","score":0.6029999852180481},{"id":"https://openalex.org/keywords/ige-antibodies","display_name":"IgE antibodies","score":0.7110000252723694},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immediate-hypersensitivity","display_name":"immediate hypersensitivity","score":0.949999988079071},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2779845534","wikidata":"https://www.wikidata.org/wiki/Q2062253","display_name":"Ascaris suum","level":3,"score":0.9892526865005493},{"id":"https://openalex.org/C2780492224","wikidata":"https://www.wikidata.org/wiki/Q310838","display_name":"Ascaris","level":3,"score":0.8650997877120972},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.775374174118042},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7588330507278442},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.6509963274002075},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.63850337266922},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6241582036018372},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6071407794952393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4961729943752289},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4896755516529083},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.42792147397994995},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.2616121470928192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001196","descriptor_name":"Ascariasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001196","descriptor_name":"Ascariasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001196","descriptor_name":"Ascariasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001200","descriptor_name":"Ascaris","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010323","descriptor_name":"Passive Cutaneous Anaphylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1535872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:6197218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:48734947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1535872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W65006800","https://openalex.org/W276603940","https://openalex.org/W1496086095","https://openalex.org/W1785005295","https://openalex.org/W1963527562","https://openalex.org/W1982443432","https://openalex.org/W1995152988","https://openalex.org/W2002983094","https://openalex.org/W2014437781","https://openalex.org/W2014580981","https://openalex.org/W2039567411","https://openalex.org/W2043297331","https://openalex.org/W2046941849","https://openalex.org/W2062958847","https://openalex.org/W2067132346","https://openalex.org/W2080489378","https://openalex.org/W2080779467","https://openalex.org/W2084037094","https://openalex.org/W2089335263","https://openalex.org/W2409450291","https://openalex.org/W2413409574"],"related_works":["https://openalex.org/W65006800","https://openalex.org/W2464146062","https://openalex.org/W2063954391","https://openalex.org/W180101848","https://openalex.org/W44139692","https://openalex.org/W2424554359","https://openalex.org/W2033425676","https://openalex.org/W2406907567","https://openalex.org/W2007146903","https://openalex.org/W2041147027"],"abstract_inverted_index":{"Wild-caught":[0],"non-human":[1],"primates":[2],"are":[3],"naturally":[4,45],"sensitive":[5],"to":[6,24,63,70,89,131,159],"Ascaris":[7,36,65,127,147],"antigen":[8],"and":[9,38,60,114,139],"provide":[10,40],"a":[11,57,82,86,108,115,156],"useful":[12],"model":[13,151],"for":[14,43],"studying":[15],"atopic":[16],"asthma.":[17],"The":[18],"present":[19],"study":[20],"was":[21],"carried":[22],"out":[23],"determine":[25],"the":[26,34,44,52,54,73,97,160],"effect":[27],"of":[28,72,104,136,152],"experimentally":[29],"infecting":[30],"home-bred":[31],"macaques":[32],"with":[33,51,126,146],"nematode":[35],"suum":[37,128],"hence":[39],"an":[41],"alternative":[42,158],"occurring":[46],"model.":[47,164],"Following":[48],"oral":[49],"infection":[50],"parasite":[53],"animals":[55],"developed":[56],"blood":[58],"eosinophilia":[59],"specific":[61],"antibodies":[62,68],"purified":[64],"antigen.":[66,148],"These":[67],"appeared":[69],"be":[71,79],"IgE":[74],"class":[75],"as":[76],"they":[77],"could":[78],"detected":[80],"by":[81],"radiometric":[83],"assay":[84],"using":[85,96],"radiolabelled":[87],"antibody":[88,105],"human":[90],"IgE.":[91],"However,":[92],"on":[93],"further":[94],"investigation,":[95],"passive":[98],"cutaneous":[99],"anaphylaxis":[100],"test,":[101],"two":[102],"classes":[103],"were":[106,129],"found,":[107],"heat":[109,116],"labile":[110],"(56":[111],"degrees":[112],"C)":[113],"stable":[117],"antibody.":[118],"Lung":[119],"lavage":[120],"cells":[121,133,138],"taken":[122],"from":[123],"monkeys":[124],"infected":[125],"shown":[130],"include":[132],"morphologically":[134],"characteristic":[135],"mast":[137],"released":[140],"histamine":[141],"when":[142],"challenged":[143],"in":[144],"vitro":[145],"Hence":[149],"this":[150],"immediate":[153],"hypersensitivity":[154],"provides":[155],"simple":[157],"less":[161],"accessible":[162],"natural":[163]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
