{"id":"https://openalex.org/W48722661","doi":null,"title":"Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells.","display_name":"Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells.","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W48722661","mag":"48722661","pmid":"https://pubmed.ncbi.nlm.nih.gov/16449943"},"language":"en","primary_location":{"id":"pmid:16449943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16449943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Van Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71965598","display_name":"Adelphi University","ror":"https://ror.org/025n13r50","country_code":"US","type":"education","lineage":["https://openalex.org/I71965598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Van Tran","raw_affiliation_strings":["Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530, USA","institution_ids":["https://openalex.org/I71965598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042170252","display_name":"Natalie Hoffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031324012","display_name":"Adaobi Mofunanaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adaobi Mofunanaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554713","display_name":"Stephen C. Pryor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen C Pryor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072277254","display_name":"Olutosin Ojugbele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olutosin Ojugbele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028142952","display_name":"Ashlea McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashlea McLaughlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lydia Gibson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lydia Gibson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087656849","display_name":"Josephine A. Bonventre","orcid":"https://orcid.org/0000-0002-8258-2432","observed_orcids":["https://orcid.org/0000-0002-8258-2432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine A Bonventre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069850857","display_name":"Katherine Flynn","orcid":"https://orcid.org/0000-0002-9623-7904","observed_orcids":["https://orcid.org/0000-0002-9623-7904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Flynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042938133","display_name":"Benjamin S. Weeks","orcid":"https://orcid.org/0000-0002-8361-0677","observed_orcids":["https://orcid.org/0000-0002-8361-0677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin S Weeks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8631,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81174334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"2","first_page":"BR57","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifenthrin","display_name":"bifenthrin","score":1.0},{"id":"https://openalex.org/keywords/pyrethroid-insecticides","display_name":"pyrethroid insecticides","score":0.9649999737739563},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pesticide-safety","display_name":"pesticide safety","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2779173036","wikidata":"https://www.wikidata.org/wiki/Q415150","display_name":"Bifenthrin","level":3,"score":0.9802101850509644},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8919812440872192},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.606974720954895},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5779615640640259},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.5760263800621033},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5551959276199341},{"id":"https://openalex.org/C2776035571","wikidata":"https://www.wikidata.org/wiki/Q745766","display_name":"Pyrethroid","level":3,"score":0.49216383695602417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49172428250312805},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.47969290614128113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46169599890708923},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.41737422347068787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35314255952835083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35013335943222046},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3271667957305908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2358035445213318},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21518301963806152},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06040024757385254},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007306","descriptor_name":"Insecticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011722","descriptor_name":"Pyrethrins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16449943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16449943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290152528","https://openalex.org/W2604461896","https://openalex.org/W2417843580","https://openalex.org/W2387715888","https://openalex.org/W2122896948","https://openalex.org/W2084189897","https://openalex.org/W2119583074","https://openalex.org/W3156895985","https://openalex.org/W63424200","https://openalex.org/W2008673871"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bifenthrin":[1],"is":[2,26],"a":[3,15,19],"third":[4],"generation":[5],"member":[6],"of":[7,12,23,42,47,54,65,84,119,152,177,181,203,232],"the":[8,33,40,45,50,78,142,158,174,201,204,212,216,220,230],"synthetic":[9],"pyrethroid":[10],"family":[11],"insecticides.":[13],"As":[14],"new":[16,21],"pesticide":[17],"within":[18],"relatively":[20,28],"class":[22],"pesticides,":[24],"bifenthrin":[25,43,68,117,180,221,235],"considered":[27],"safe.":[29],"Here,":[30],"we":[31],"used":[32],"PC12":[34,58,104,135],"neuronal":[35],"cell":[36,105],"line":[37],"to":[38,62,116,134,211,240],"examine":[39],"effect":[41],"on":[44],"formation":[46],"neurites":[48],"and":[49,93,110,122,155,170,184,193,218],"potential":[51],"developmental":[52],"neurotoxicity":[53],"this":[55],"pesticide.":[56],"MATERIAL/METHODS:":[57],"cells":[59,136],"were":[60,87],"exposed":[61],"varying":[63],"concentrations":[64,83,118,151,176],"technical":[66,128,178],"grade":[67,129,179],"or":[69],"Ortho":[70,99,159,205],"Home":[71,100,160,206],"Defense.":[72],"Cell":[73],"viability":[74,106],"was":[75,96,131,141,147,209],"determined":[76],"using":[77],"AlmarBlue":[79],"Toxicity":[80],"Assay.":[81],"Nontoxic":[82],"these":[85,224],"chemicals":[86],"concomitantly":[88],"with":[89],"nerve":[90,163],"growth":[91,164],"factor":[92],"neurite":[94,166,188],"outgrowth":[95,167,189],"assessed.":[97],"RESULTS:":[98],"Defense":[101,161,207],"preparation":[102,208,217],"reduced":[103],"by":[107,168,190],"approximately":[108,191],"50%":[109],"70%":[111],"at":[112,137],"dilutions":[113],"that":[114,146,200],"correlate":[115],"10(-5)":[120],"M":[121,154,183,186],"10(-4)":[123],"M,":[124,139,157],"respectively.":[125,172,195],"In":[126],"contrast,":[127],"bifenthrin,":[130],"not":[132,219],"toxic":[133],"10(-3)":[138,185],"which":[140],"highest":[143],"concentration":[144],"tested":[145],"soluble.":[148],"At":[149],"\"nontoxic\"":[150],"10(-7)":[153],"10(-6)":[156,182],"inhibited":[162,187],"factor-mediated":[165],"30%":[169],"55%":[171],"Furthermore":[173],"nontoxic":[175],"35%":[192],"75%":[194],"CONCLUSIONS:":[196],"These":[197],"data":[198,225],"suggest":[199,226],"toxicity":[202],"due":[210],"\"inert\"":[213],"additives":[214],"in":[215,229],"itself.":[222],"Further,":[223],"that,":[227],"even":[228],"absence":[231],"overt":[233],"toxicity,":[234],"may":[236],"have":[237],"deleterious":[238],"effects":[239],"developing":[241],"nervous":[242],"system.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}