{"id":"https://openalex.org/W48621102","doi":null,"title":"Effects of thymus size and involution on the contribution of recent thymic emigrants to the peripheral T cell pool","display_name":"Effects of thymus size and involution on the contribution of recent thymic emigrants to the peripheral T cell pool","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W48621102","mag":"48621102"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1268","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037402933","display_name":"Michelle L. Bolner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michelle L. Bolner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037402933"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.9480000138282776},{"id":"https://openalex.org/keywords/recent-thymic-emigrants","display_name":"recent thymic emigrants","score":0.9120000004768372},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/thymic-output","display_name":"thymic output","score":0.6159999966621399},{"id":"https://openalex.org/keywords/t-cell-receptor-diversity","display_name":"T cell receptor diversity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/thymus-regeneration","display_name":"thymus regeneration","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.746999979019165},{"id":"https://openalex.org/keywords/thymic-hyperplasia","display_name":"thymic hyperplasia","score":0.7080000042915344},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.42399999499320984},{"id":"https://openalex.org/keywords/thymopoiesis","display_name":"thymopoiesis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2781409172","wikidata":"https://www.wikidata.org/wiki/Q17056802","display_name":"Involution (esoterism)","level":3,"score":0.81328284740448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4808829128742218},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4678559899330139},{"id":"https://openalex.org/C2777314012","wikidata":"https://www.wikidata.org/wiki/Q7799617","display_name":"Thymic involution","level":4,"score":0.46302857995033264},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.37859708070755005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3521084487438202},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3493937849998474},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13707643747329712},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1268","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:48621102","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1268&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1268","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/235","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W48621102.pdf","grobid_xml":"https://content.openalex.org/works/W48621102.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1503131941","https://openalex.org/W1503928854","https://openalex.org/W1522681356","https://openalex.org/W1533027544","https://openalex.org/W1572198948","https://openalex.org/W1593954658","https://openalex.org/W1595728038","https://openalex.org/W1605474806","https://openalex.org/W1917895031","https://openalex.org/W1964077677","https://openalex.org/W1964848002","https://openalex.org/W1966534825","https://openalex.org/W1967876166","https://openalex.org/W1970876023","https://openalex.org/W1974346743","https://openalex.org/W1976062745","https://openalex.org/W1976505472","https://openalex.org/W1980896849","https://openalex.org/W1983336399","https://openalex.org/W1985718208","https://openalex.org/W1989969635","https://openalex.org/W1993779367","https://openalex.org/W1997356339","https://openalex.org/W1998062490","https://openalex.org/W1998074063","https://openalex.org/W2000423452","https://openalex.org/W2004842826","https://openalex.org/W2004880863","https://openalex.org/W2006985918","https://openalex.org/W2009127800","https://openalex.org/W2014409901","https://openalex.org/W2016429173","https://openalex.org/W2016430734","https://openalex.org/W2016768070","https://openalex.org/W2018311782","https://openalex.org/W2020336227","https://openalex.org/W2020921250","https://openalex.org/W2026340246","https://openalex.org/W2033121902","https://openalex.org/W2035468000","https://openalex.org/W2041672277","https://openalex.org/W2042108397","https://openalex.org/W2044442038","https://openalex.org/W2049675300","https://openalex.org/W2054074133","https://openalex.org/W2057459783","https://openalex.org/W2057698592","https://openalex.org/W2058299309","https://openalex.org/W2058933354","https://openalex.org/W2059984497","https://openalex.org/W2062036642","https://openalex.org/W2066197777","https://openalex.org/W2067788119","https://openalex.org/W2068493773","https://openalex.org/W2070570719","https://openalex.org/W2080737275","https://openalex.org/W2081843353","https://openalex.org/W2082672875","https://openalex.org/W2090034696","https://openalex.org/W2096584806","https://openalex.org/W2098503878","https://openalex.org/W2100302650","https://openalex.org/W2105381977","https://openalex.org/W2112729981","https://openalex.org/W2115505075","https://openalex.org/W2118606008","https://openalex.org/W2124610030","https://openalex.org/W2125550036","https://openalex.org/W2128449161","https://openalex.org/W2140058614","https://openalex.org/W2144437446","https://openalex.org/W2147246759","https://openalex.org/W2149488526","https://openalex.org/W2155048915","https://openalex.org/W2155696890","https://openalex.org/W2156646599","https://openalex.org/W2165664782","https://openalex.org/W2166102027","https://openalex.org/W2167137886","https://openalex.org/W2167965906"],"related_works":["https://openalex.org/W1530398086","https://openalex.org/W4313385803","https://openalex.org/W2265653545","https://openalex.org/W7097992863","https://openalex.org/W2016429173","https://openalex.org/W7099460633","https://openalex.org/W1880149719","https://openalex.org/W1988389319","https://openalex.org/W1967663680","https://openalex.org/W7096302976"],"abstract_inverted_index":{"The":[0,34,158,181],"contribution":[1],"of":[2,19,63,177,185,201,220],"recent":[3],"thymic":[4,85],"emigrants":[5],"(RTEs)":[6],"to":[7,16,45,59,70,76,110,130,150,163,198],"the":[8,20,126,132,145,164,175,178,218,223],"peripheral":[9,64,93,146,224],"na\u00efve":[10,152,188],"T":[11,21,65,147,153,191,225],"cell":[12,22,148,154,226],"population":[13],"is":[14],"necessary":[15],"maintain":[17,215],"diversity":[18,62],"receptor":[23],"(TCR)":[24],"repertoire":[25],"and":[26,43,55,72,91,115,142,183,229],"produce":[27],"immune":[28,74],"responses":[29],"against":[30],"newly":[31],"encountered":[32],"antigens.":[33],"thymus":[35,107,136,212,231],"involutes":[36],"with":[37,156],"age,":[38],"after":[39,230],"irradiation":[40],"or":[41,83,216],"chemotherapy,":[42],"due":[44],"severe":[46],"viral":[47],"infections.":[48],"Thymus":[49],"involution":[50,137,213],"results":[51],"in":[52,120,187,222],"decreased":[53],"thymopoiesis":[54],"RTE":[56,140],"output":[57,141],"leading":[58],"a":[60,99,104],"reduced":[61],"cells.":[66],"This":[67],"increases":[68],"susceptibility":[69],"disease":[71],"impairs":[73],"responsiveness":[75],"vaccines.":[77],"Therefore,":[78],"studies":[79],"aimed":[80],"at":[81,195],"maintaining":[82,90],"regenerating":[84],"function":[86],"are":[87],"integral":[88],"for":[89],"restoring":[92],"TCR":[94],"diversity.":[95],"Mice":[96],"that":[97,108,134,169,210],"express":[98],"K5.CyclinD1":[100,127,159],"transgene":[101,160],"expression":[102],"have":[103,124],"severely":[105],"hyperplastic":[106],"fails":[109],"undergo":[111],"involution.":[112,232],"Both":[113],"thymocyte":[114],"TEC":[116],"development":[117],"appear":[118],"normal":[119],"these":[121],"mice.":[122],"We":[123],"used":[125],"transgenic":[128,166,206],"model":[129,167],"test":[131],"hypothesis":[133],"preventing":[135,211],"will":[138],"sustain":[139],"incorporation":[143],"into":[144],"pool":[149,227],"prevent":[151],"depletion":[155],"age.":[157,202],"was":[161,193],"crossed":[162],"RAG2p-GFP":[165],"so":[168],"RTEs":[170,186,221],"could":[171],"be":[172],"tracked":[173],"by":[174],"intensity":[176],"GFP":[179],"signal.":[180],"frequency":[182],"number":[184,219],"CD4":[189],"splenic":[190],"cells":[192],"analyzed":[194],"monthly":[196],"intervals":[197],"5":[199],"months":[200],"Using":[203],"this":[204],"double":[205],"approach,":[207],"we":[208],"determined":[209],"does":[214],"enhance":[217],"before":[228]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}