{"id":"https://openalex.org/W48502498","doi":null,"title":"Impaired endothelium-dependent vasorelaxation in peripheral vasculature of patients with thromboangiitis obliterans (Buerger's disease).","display_name":"Impaired endothelium-dependent vasorelaxation in peripheral vasculature of patients with thromboangiitis obliterans (Buerger's disease).","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W48502498","mag":"48502498","pmid":"https://pubmed.ncbi.nlm.nih.gov/8901748"},"language":"en","primary_location":{"id":"pmid:8901748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023453792","display_name":"Shinji Makita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Makita","raw_affiliation_strings":["Second Department of Internal Medicine, Iwate Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Iwate Medical University, Japan","institution_ids":["https://openalex.org/I180680657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111164144","display_name":"M. Nakamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019561023","display_name":"Hiroko Murakami","orcid":"https://orcid.org/0000-0002-7716-7656","observed_orcids":["https://orcid.org/0000-0002-7716-7656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Murakami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051291365","display_name":"K Komoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Komoda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112184941","display_name":"Kohei Kawazoe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kawazoe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111707067","display_name":"K Hiramori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hiramori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6215,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.64033398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"94","issue":"9 Suppl","first_page":"II211","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboangiitis-obliterans","display_name":"thromboangiitis obliterans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/forearm-blood-flow","display_name":"forearm blood flow","score":0.7730000019073486},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9810000061988831},{"id":"https://openalex.org/keywords/reactive-hyperemia","display_name":"reactive hyperemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/peripheral-vascular-dysfunction","display_name":"peripheral vascular dysfunction","score":0.6729999780654907},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8978734612464905},{"id":"https://openalex.org/C3019128504","wikidata":"https://www.wikidata.org/wiki/Q948806","display_name":"Reactive hyperemia","level":3,"score":0.8136783838272095},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.7157818675041199},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6945483088493347},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6749987006187439},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5840197801589966},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5390448570251465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5343078374862671},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5179914236068726},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.44548267126083374},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.43403980135917664},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3489200472831726},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2302865982055664}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005542","descriptor_name":"Forearm","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013919","descriptor_name":"Thromboangiitis Obliterans","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8901748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"mag:48502498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320755917","https://openalex.org/W1481619107","https://openalex.org/W4237300302","https://openalex.org/W7095652824","https://openalex.org/W1994051197","https://openalex.org/W1991778670","https://openalex.org/W1966316294","https://openalex.org/W2330529022","https://openalex.org/W3174870855","https://openalex.org/W1512172521"],"abstract_inverted_index":{"BACKGROUND:":[0],"Thromboangiitis":[1],"obliterans":[2],"(TAO)":[3],"is":[4,30,47,250],"an":[5,51],"occlusive":[6],"arterial":[7],"disease":[8,12],"and":[9,22,60,102,114,123,274],"a":[10],"separate":[11],"entity":[13],"from":[14],"atherosclerosis.":[15],"It":[16],"occurs":[17],"mainly":[18],"in":[19,40,54,75,109,115,128,137,142,171,174,252,277],"the":[20,26,55,61,69,76,93,97,172,182,204,215,253,278],"small":[21],"medium-sized":[23],"vessels.":[24],"Although":[25],"cause":[27],"of":[28,57,63,72,79,158,197,206,222,236,256,262,281],"TAO":[29,113,140],"unknown,":[31],"systemic":[32],"factors":[33],"(immunological":[34],"or":[35],"humoral)":[36],"may":[37,265],"be":[38],"involved":[39],"addition":[41],"to":[42,131,177,267],"abnormal":[43],"peripheral":[44,77,247,279],"microcirculation.":[45],"Endothelium":[46],"now":[48],"recognized":[49],"as":[50,270],"important":[52],"factor":[53],"maintenance":[56],"microvascular":[58],"circulation":[59],"inhibition":[62],"platelet":[64],"aggregation.":[65],"This":[66,260],"study":[67],"examines":[68],"possible":[70],"impairment":[71],"endothelium-dependent":[73,94,248],"vasodilation":[74,249],"vasculature":[78],"patients":[80,111,138,257,282],"with":[81,112,139,258,283],"TAO.":[82,259,284],"METHODS":[83],"AND":[84],"RESULTS:":[85],"Forearm":[86],"blood":[87],"flow":[88],"(FBF)":[89],"changes":[90],"induced":[91],"by":[92],"vasodilator":[95,99],"acetylcholine,":[96],"endothelium-independent":[98],"sodium":[100,178],"nitroprusside,":[101],"occlusion-induced":[103],"reactive":[104,207],"hyperemia":[105,223],"were":[106,210],"measured":[107],"plethysmographically":[108],"eight":[110,116],"healthy":[117,143],"control":[118,144],"subjects":[119,145],"matched":[120],"for":[121],"age":[122],"smoking":[124],"status.":[125],"The":[126],"increase":[127,173],"FBF":[129,175,186],"response":[130,176],"intra-arterial":[132],"acetylcholine":[133],"infusion":[134,180],"was":[135,167],"lower":[136],"than":[141],"(peak":[146,185,224],"FBF,":[147,225],"22.9":[148],"+/-":[149,153,188,192,227,231],"2.9":[150],"versus":[151,190,229],"14.1":[152],"2.8":[154],"mL/min":[155,194,233],"per":[156,195,234],"dL":[157,196,235],"tissue":[159,198,237],"volume;":[160,199,238],"P":[161,200,239],"<":[162],".01).":[163],"In":[164,203],"contrast,":[165],"there":[166,209],"no":[168,211],"significant":[169,212],"difference":[170],"nitroprusside":[179],"between":[181,214],"two":[183,216],"groups":[184,217],"13.1":[187],"4.0":[189,228],"16.3":[191],"2.5":[193],"=":[201,240],"NS).":[202,241],"case":[205],"hyperemia,":[208],"differences":[213],"at":[218],"any":[219],"time":[220],"points":[221],"32.9":[226],"31.4":[230],"3.3":[232],"CONCLUSIONS:":[242],"These":[243],"results":[244],"indicate":[245],"that":[246],"impaired":[251],"nondiseased":[254],"limb":[255],"type":[261],"vascular":[263],"dysfunction":[264],"contribute":[266],"such":[268],"characteristics":[269],"segmental":[271],"proliferative":[272],"lesion":[273],"thrombus":[275],"formation":[276],"vessels":[280]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}