{"id":"https://openalex.org/W48379418","doi":null,"title":"Scanning Probe Microscopy: Applications for Genomic Research","display_name":"Scanning Probe Microscopy: Applications for Genomic Research","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W48379418","mag":"48379418"},"language":"en","primary_location":{"id":"mag:48379418","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/cgi/viewcontent.cgi?article=1159&context=utk_graddiss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042226095","display_name":"David P. Allison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David P. Allison","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# University of Tennessee#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# University of Tennessee#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042226095"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00423299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10913","display_name":"Molecular Junctions and Nanostructures","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12285","display_name":"Surface Chemistry and Catalysis","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scanning-tunneling-microscopy","display_name":"scanning tunneling microscopy","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dna-imaging","display_name":"DNA imaging","score":0.5270000100135803},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.746999979019165},{"id":"https://openalex.org/keywords/scanning-tunneling-spectroscopy","display_name":"scanning tunneling spectroscopy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tobacco-mosaic-virus","display_name":"tobacco mosaic virus","score":0.6230000257492065},{"id":"https://openalex.org/keywords/highly-ordered-pyrolytic-graphite","display_name":"highly ordered pyrolytic graphite","score":0.9509999752044678},{"id":"https://openalex.org/keywords/self-assembled-monolayers","display_name":"self-assembled monolayers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/plasmid-dna","display_name":"plasmid DNA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dna-immobilization","display_name":"DNA immobilization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/gold-surfaces","display_name":"gold surfaces","score":0.546999990940094},{"id":"https://openalex.org/keywords/human-genome-sequencing","display_name":"human genome sequencing","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C6518042","wikidata":"https://www.wikidata.org/wiki/Q175646","display_name":"Scanning tunneling microscope","level":2,"score":0.768048882484436},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5753858089447021},{"id":"https://openalex.org/C36628996","wikidata":"https://www.wikidata.org/wiki/Q907287","display_name":"Scanning probe microscopy","level":2,"score":0.5099965333938599},{"id":"https://openalex.org/C194577767","wikidata":"https://www.wikidata.org/wiki/Q1651687","display_name":"Scanning tunneling spectroscopy","level":3,"score":0.46362021565437317},{"id":"https://openalex.org/C2778461158","wikidata":"https://www.wikidata.org/wiki/Q23906103","display_name":"Highly oriented pyrolytic graphite","level":3,"score":0.456623911857605},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.43605631589889526},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.41024094820022583},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38055235147476196},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.20034602284431458},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15400409698486328},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:48379418","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/cgi/viewcontent.cgi?article=1159&context=utk_graddiss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W11096920","https://openalex.org/W810454239","https://openalex.org/W1492566521","https://openalex.org/W1501673075","https://openalex.org/W1521830831","https://openalex.org/W1525178364","https://openalex.org/W1604022724","https://openalex.org/W1691391852","https://openalex.org/W1963895341","https://openalex.org/W1972068936","https://openalex.org/W1973069050","https://openalex.org/W1973245669","https://openalex.org/W1974262428","https://openalex.org/W1974732581","https://openalex.org/W1975534235","https://openalex.org/W1976051330","https://openalex.org/W1976967195","https://openalex.org/W1979197786","https://openalex.org/W1980840066","https://openalex.org/W1981225113","https://openalex.org/W1985093835","https://openalex.org/W1987007760","https://openalex.org/W1987088025","https://openalex.org/W1987637234","https://openalex.org/W1989336153","https://openalex.org/W1989533572","https://openalex.org/W1990062893","https://openalex.org/W1990784107","https://openalex.org/W1991290080","https://openalex.org/W1991687023","https://openalex.org/W1999288045","https://openalex.org/W2001583897","https://openalex.org/W2012792065","https://openalex.org/W2013280951","https://openalex.org/W2013833231","https://openalex.org/W2015314153","https://openalex.org/W2015498249","https://openalex.org/W2015867923","https://openalex.org/W2018529964","https://openalex.org/W2018575885","https://openalex.org/W2018807441","https://openalex.org/W2019152963","https://openalex.org/W2020341558","https://openalex.org/W2022369106","https://openalex.org/W2023015922","https://openalex.org/W2023517171","https://openalex.org/W2026731443","https://openalex.org/W2026826482","https://openalex.org/W2030244101","https://openalex.org/W2031070176","https://openalex.org/W2031539567","https://openalex.org/W2032379826","https://openalex.org/W2032686619","https://openalex.org/W2033813349","https://openalex.org/W2033896550","https://openalex.org/W2044556925","https://openalex.org/W2045829473","https://openalex.org/W2047244438","https://openalex.org/W2048751903","https://openalex.org/W2050879305","https://openalex.org/W2052983606","https://openalex.org/W2055266556","https://openalex.org/W2055759100","https://openalex.org/W2056009643","https://openalex.org/W2056182522","https://openalex.org/W2056648038","https://openalex.org/W2056950366","https://openalex.org/W2057499896","https://openalex.org/W2058346737","https://openalex.org/W2058912578","https://openalex.org/W2061253726","https://openalex.org/W2064588211","https://openalex.org/W2067326868","https://openalex.org/W2072620858","https://openalex.org/W2075956461","https://openalex.org/W2076111440","https://openalex.org/W2076669144","https://openalex.org/W2077813193","https://openalex.org/W2077943655","https://openalex.org/W2079787889","https://openalex.org/W2080167650","https://openalex.org/W2081784115","https://openalex.org/W2081883839","https://openalex.org/W2082076179","https://openalex.org/W2084602427","https://openalex.org/W2088182455","https://openalex.org/W2090051935","https://openalex.org/W2090118483","https://openalex.org/W2091656492","https://openalex.org/W2092895126","https://openalex.org/W2104559182","https://openalex.org/W2110115088","https://openalex.org/W2117962550","https://openalex.org/W2128957878","https://openalex.org/W2137764324","https://openalex.org/W2167235502","https://openalex.org/W2180298057","https://openalex.org/W2416379057","https://openalex.org/W2490491073","https://openalex.org/W2513797480","https://openalex.org/W2568203515","https://openalex.org/W2733510318","https://openalex.org/W3150248096"],"related_works":["https://openalex.org/W2088125699","https://openalex.org/W4235658858","https://openalex.org/W7095229774","https://openalex.org/W2017883529","https://openalex.org/W3036877299","https://openalex.org/W2145901788","https://openalex.org/W2004868517","https://openalex.org/W7099979756","https://openalex.org/W2339194657","https://openalex.org/W2416379057"],"abstract_inverted_index":{"The":[0],"inauguration":[1],"of":[2,12,19,31,53,113,130,138,173,209,242,280,292],"the":[3,9,13,17,32,51,55,60,72,87,93,111,126,139,148,206,243,248,288],"International":[4],"Human":[5],"Genome":[6],"Initiative":[7],"in":[8,67,77,97,107,125,152,219,239],"later":[10],"part":[11],"1980\u2019s":[14],"coincided":[15],"with":[16,201,272],"development":[18],"scanning":[20,61,131,143,169],"probe":[21],"microscopy":[22],"(SPM).":[23],"SPM":[24],"was":[25,65,82,118,150],"a":[26,47,277],"good":[27],"fit":[28],"as":[29,156],"one":[30,137],"new":[33,104],"technologies":[34],"that":[35,86,120,205,226],"might":[36,212],"be":[37,213],"implemented":[38],"to":[39,179,215,233,254],"sequence":[40,216],"or":[41,231,235],"map":[42],"DNA":[43,157,186,202,232,260,297],"and":[44,71,128,168,184],"perhaps":[45],"make":[46],"major":[48],"contribution":[49],"toward":[50],"goal":[52],"sequencing":[54],"entire":[56,293],"human":[57],"genome.":[58],"Although":[59],"tunneling":[62,132,144,170,250],"microscope":[63,75],"(STM)":[64],"invented":[66],"1982":[68],"[Binnig":[69,79],"1982]":[70],"atomic":[73],"force":[74],"(AFM)":[76],"1986":[78],"1986],":[80],"it":[81],"not":[83],"until":[84],"1987":[85],"first":[88,140,289],"STM":[89,166,249,265,301],"became":[90,95],"commercially":[91,141],"available;":[92],"AFM":[94],"available":[96,142],"1989.":[98],"Our":[99,161,198],"group":[100],"entered":[101],"this":[102,220,284],"exciting":[103],"scientific":[105],"adventure":[106],"genome":[108],"research":[109,163],"towards":[110],"end":[112],"1987.":[114],"An":[115],"interdisciplinary":[116],"team":[117,149],"assembled":[119],"capitalized":[121],"on":[122,165,189],"our":[123],"expertise":[124,151],"fabrication":[127],"use":[129],"microscopes.":[133,145],"Additionally,":[134],"we":[135,223,267,286],"purchased":[136],"Rounding":[146],"out":[147],"imaging":[153,167],"biomolecules":[154],"such":[155],"using":[158],"electron":[159],"microscopy.":[160],"initial":[162],"focused":[164],"spectroscopy":[171,199],"(STS)":[172],"1)":[174],"tobacco":[175],"mosaic":[176],"virus":[177,230],"adsorbed":[178],"gold":[180,234,269],"surfaces":[181,195,237,263,271],"[Mantovani":[182],"1990]":[183],"2)":[185],"passively":[187],"mounted":[188],"highly":[190],"ordered":[191],"pyrolytic":[192],"graphite":[193],"(HOPG)":[194],"[Allison":[196,302],"1990].":[197],"results":[200],"encouraged":[203],"speculation":[204],"electronic":[207],"signatures":[208],"nucleotide":[210],"bases":[211],"used":[214],"DNA.":[217],"However,":[218],"early":[221],"work":[222],"also":[224],"discovered":[225],"simply":[227],"adsorbing":[228],"either":[229],"HOPG":[236],"resulted":[238],"substantial":[240],"amounts":[241],"sample":[244,270],"being":[245],"removed":[246],"by":[247,276,300],"tip.":[251],"In":[252],"order":[253],"more":[255],"firmly":[256],"immobilize":[257],"negatively":[258],"charged":[259],"molecules":[261,298],"onto":[262],"for":[264],"scanning,":[266],"created":[268],"positive":[273],"functionality":[274],"mediated":[275],"self-assembled":[278],"monolayer":[279],"2-dimethylaminoethane":[281],"thiol.":[282],"Using":[283],"method,":[285],"produced":[287],"reported":[290],"images":[291],"genetically":[294],"functional":[295],"plasmid":[296],"obtained":[299],"1992a,":[303],"Allison":[304,306],"1992b":[305],"1993,":[307],"Bottomley":[308],"1992].":[309]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}