{"id":"https://openalex.org/W4831423","doi":"https://doi.org/10.2174/1872312808666140317154110","title":"Metabolite Characterization of Anti-cancer Agent Gefitinib in Human Hepatocytes","display_name":"Metabolite Characterization of Anti-cancer Agent Gefitinib in Human Hepatocytes","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W4831423","doi":"https://doi.org/10.2174/1872312808666140317154110","mag":"4831423","pmid":"https://pubmed.ncbi.nlm.nih.gov/24628403"},"language":"en","primary_location":{"id":"doi:10.2174/1872312808666140317154110","doi":"https://doi.org/10.2174/1872312808666140317154110","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1872312808666140317154110","pdf_url":null,"source":{"id":"https://openalex.org/S51092485","display_name":"Drug Metabolism Letters","issn_l":"1872-3128","issn":["1872-3128","1874-0758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073449622","display_name":"Prashant Surve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashant Surve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007944620","display_name":"Selvan Ravindran","orcid":"https://orcid.org/0000-0001-6846-319X","observed_orcids":["https://orcid.org/0000-0001-6846-319X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selvan Ravindran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080430107","display_name":"Arghya Acharjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arghya Acharjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052692802","display_name":"Himanshu Rastogi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Himanshu Rastogi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sudipta Basu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudipta Basu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046544655","display_name":"Pradnya Honrao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pradnya Honrao","raw_affiliation_strings":["Departments of Bio- Analytical and Biotransformation, Drug Metabolism and Pharmacokinetics Unit, Sai Life Sciences Limited, Building 1, Plot No 2, Chrysalis Enclave, International Biotech Park, Pune 411057, Maharashtra, India. selvan_ravindran@yahoo.com","Departments of Bio- Analytical and Biotransformation, Drug Metabolism and Pharmacokinetics Unit, Sai Life Sciences Limited, Building 1, Plot No 2, Chrysalis Enclave, International Biotech Park, Pune 411057, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bio- Analytical and Biotransformation, Drug Metabolism and Pharmacokinetics Unit, Sai Life Sciences Limited, Building 1, Plot No 2, Chrysalis Enclave, International Biotech Park, Pune 411057, Maharashtra, India. selvan_ravindran@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Departments of Bio- Analytical and Biotransformation, Drug Metabolism and Pharmacokinetics Unit, Sai Life Sciences Limited, Building 1, Plot No 2, Chrysalis Enclave, International Biotech Park, Pune 411057, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7565,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82481622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"2","first_page":"126","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6959999799728394},{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/phase-i-metabolites","display_name":"phase I metabolites","score":0.7670000195503235},{"id":"https://openalex.org/keywords/phase-ii-metabolites","display_name":"phase II metabolites","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-defluorination","display_name":"oxidative defluorination","score":0.871999979019165},{"id":"https://openalex.org/keywords/n-dealkylation","display_name":"N-dealkylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutathione-adducts","display_name":"glutathione adducts","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors","display_name":"epidermal growth factor receptor tyrosine kinase inhibitors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/metabolite-characterization","display_name":"metabolite characterization","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9899517297744751},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6180956363677979},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.5809047222137451},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5610802173614502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4909529983997345},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.48950254917144775},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47267183661460876},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4421869218349457},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4154275059700012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32871925830841064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3264603614807129},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32496529817581177},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2293718457221985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19858315587043762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19146835803985596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1772124171257019}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003640","descriptor_name":"Dealkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003640","descriptor_name":"Dealkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003640","descriptor_name":"Dealkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050216","descriptor_name":"Metabolic Detoxication, Phase I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050216","descriptor_name":"Metabolic Detoxication, Phase I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050216","descriptor_name":"Metabolic Detoxication, Phase I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050217","descriptor_name":"Metabolic Detoxication, Phase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050217","descriptor_name":"Metabolic Detoxication, Phase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050217","descriptor_name":"Metabolic Detoxication, Phase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1872312808666140317154110","doi":"https://doi.org/10.2174/1872312808666140317154110","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1872312808666140317154110","pdf_url":null,"source":{"id":"https://openalex.org/S51092485","display_name":"Drug Metabolism Letters","issn_l":"1872-3128","issn":["1872-3128","1874-0758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism Letters","raw_type":"journal-article"},{"id":"pmid:24628403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24628403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2254126652","https://openalex.org/W2418692205","https://openalex.org/W2015104488","https://openalex.org/W3147989365","https://openalex.org/W2280113021","https://openalex.org/W2408927976","https://openalex.org/W2348666640","https://openalex.org/W2363852307","https://openalex.org/W2184487997","https://openalex.org/W2168841302"],"abstract_inverted_index":{"Intensive":[0],"Biotransformation":[1],"studies":[2,23],"on":[3],"Gefitinib":[4,40,54,71,92,120],"could":[5],"play":[6],"a":[7],"significant":[8],"role":[9],"in":[10,27,38,84,116],"designing":[11],"and":[12,60,129,142,170],"synthesizing":[13],"new":[14,31],"drugs":[15],"around":[16],"the":[17,35,43,62,66,77,117,149,154,158,162,165],"core":[18],"structure":[19,163],"of":[20,68,76,144,148,164],"Gefitinib.":[21,39,114],"These":[22],"may":[24],"be":[25,82],"useful":[26],"developing":[28],"an":[29],"entirely":[30],"drug":[32,166],"by":[33],"blocking":[34],"metabolic":[36],"spots":[37],"(Iressa)":[41],"was":[42,102,121],"first":[44],"oral":[45],"epidermal":[46],"growth":[47,67],"factor":[48],"receptor":[49],"(EGFR)":[50],"tyrosine":[51],"kinase":[52],"inhibitor.":[53],"shows":[55],"toxicity":[56],"to":[57,64,81,109,113,125,138,160],"cancer":[58,69,97],"cells":[59],"has":[61],"capability":[63],"inhibit":[65],"cells.":[70],"is":[72],"considered":[73],"as":[74],"one":[75],"selective":[78],"EGFR":[79],"inhibitors":[80],"available":[83],"clinical":[85],"practice.":[86],"In":[87],"2003,":[88],"FDA":[89],"had":[90],"approved":[91],"for":[93,167],"metastatic":[94],"non-small-cell":[95],"lung":[96],"therapy":[98],"(NSCLC).":[99],"However,":[100],"it":[101],"observed":[103],"that":[104],"NSCLC":[105],"Patients":[106],"who":[107],"responded":[108],"treatment":[110],"developed":[111],"resistance":[112],"Hence,":[115],"present":[118],"study":[119],"incubated":[122],"with":[123],"hepatocytes":[124],"identify":[126],"both":[127],"phase-I":[128],"Phase-II":[130],"metabolites.":[131],"Identified":[132],"Phase":[133],"-I":[134],"metabolites":[135,151],"were":[136],"due":[137],"oxidative":[139],"defluorination,":[140],"N-dealkylation":[141],"loss":[143],"morpholine":[145],"ring.":[146],"One":[147],"phase-II":[150],"identified":[152],"i.e.":[153],"glutathione":[155],"adduct":[156],"suggests":[157],"need":[159],"modify":[161],"higher":[168],"potency":[169],"safety.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
