{"id":"https://openalex.org/W48302960","doi":null,"title":"Penicillin levels following the administration of benzathine penicillin G in pregnancy.","display_name":"Penicillin levels following the administration of benzathine penicillin G in pregnancy.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W48302960","mag":"48302960","pmid":"https://pubmed.ncbi.nlm.nih.gov/8355931"},"language":"en","primary_location":{"id":"pmid:8355931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8355931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics and gynecology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058721213","display_name":"Lawrence E. Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Nathan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas","Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048541069","display_name":"Roger E. Bawdon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Bawdon","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050250968","display_name":"J. Elaine Sidawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Sidawi","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028664419","display_name":"R. William Stettler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Stettler","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050245474","display_name":"McIntire Dm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M McIntire","raw_affiliation_strings":["Obstetrics & Gynecology - Chairman's Office"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics & Gynecology - Chairman's Office","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112177293","display_name":"George D. Wendel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Wendel","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9388,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.72366445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"82","issue":"3","first_page":"338","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzathine-penicillin-g","display_name":"benzathine penicillin G","score":0.9980000257492065},{"id":"https://openalex.org/keywords/penicillin-pharmacokinetics","display_name":"penicillin pharmacokinetics","score":0.828000009059906},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/placental-drug-transfer","display_name":"maternal-fetal drug transfer","score":0.6330000162124634},{"id":"https://openalex.org/keywords/amniotic-fluid","display_name":"amniotic fluid","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8389999866485596},{"id":"https://openalex.org/keywords/umbilical-cord-serum","display_name":"umbilical cord serum","score":0.9190000295639038},{"id":"https://openalex.org/keywords/congenital-syphilis-prevention","display_name":"congenital syphilis prevention","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intramuscular-penicillin","display_name":"intramuscular penicillin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/term-pregnancy","display_name":"term pregnancy","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9090077877044678},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.8274032473564148},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6047114729881287},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.5779052972793579},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4972703754901886},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.47637149691581726},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.441506028175354},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4254136085510254},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.414573609828949},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.34912848472595215},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3483526110649109},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757115364074707},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.05549931526184082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000653","descriptor_name":"Amniotic Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010401","descriptor_name":"Penicillin G Benzathine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010401","descriptor_name":"Penicillin G Benzathine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8355931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8355931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics and gynecology","raw_type":"Journal Article"},{"id":"mag:48302960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8355931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006363683","https://openalex.org/W2044656416","https://openalex.org/W3091416319","https://openalex.org/W7156859082","https://openalex.org/W1981226186","https://openalex.org/W2048572038","https://openalex.org/W2314006643","https://openalex.org/W2005244179","https://openalex.org/W2004064464","https://openalex.org/W2060155789"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,8,92,169,213,242,253],"distribution":[4],"of":[5,157,185,203,230,244,249],"penicillin":[6,33,103,128,161,191,204,232],"in":[7,101,133,168,208,212,252],"maternal-placental-fetal":[9],"unit":[10],"at":[11,18,72,105,163,210],"term":[12,211],"gestation.":[13,255],"METHODS:":[14],"Twenty-five":[15],"healthy":[16],"gravidas":[17,209],"38-39":[19],"weeks'":[20],"gestation":[21],"scheduled":[22],"for":[23,113,247],"elective":[24],"repeat":[25],"cesarean":[26],"delivery":[27],"under":[28],"spinal":[29],"anesthesia":[30],"received":[31],"benzathine":[32,231],"G,":[34],"2.4":[35,227],"million":[36,228],"units":[37,229],"intramuscularly":[38],"(IM)":[39],"preoperatively.":[40],"Ten":[41],"women":[42,187],"delivered":[43,49,55],"1":[44,142,176,224],"day":[45,106,108,111,143,175,178],"after":[46,144,153,226],"injection,":[47],"five":[48],"2-3":[50],"days":[51,57,152],"after,":[52],"and":[53,63,69,221],"ten":[54],"7":[56,112,151,179],"after.":[58],"We":[59,235],"collected":[60],"maternal":[61,114,116,134,170,214],"serum":[62,71,135,171,190],"cerebrospinal":[64,117,216],"fluid,":[65,118,217],"amniotic":[66],"fluid":[67],"(AF),":[68],"cord":[70,119,219],"delivery.":[73],"Penicillin":[74],"levels":[75,104,192,205],"were":[76,194,206],"measured":[77],"using":[78],"a":[79,160],"validated":[80],"agar":[81],"disc":[82],"diffusion":[83],"method":[84],"(sensitivity":[85],"0.006":[86],"micrograms/mL)":[87,132],"with":[88,159],"Micrococcus":[89],"lutea":[90],"as":[91],"test":[93],"organism.":[94],"RESULTS:":[95],"There":[96],"was":[97],"no":[98],"significant":[99],"difference":[100],"mean":[102,124],"1,":[107],"2-3,":[109],"or":[110,121,164],"serum,":[115,120,215,220],"AF.":[122],"The":[123,155],"(+/-":[125],"standard":[126],"error)":[127],"concentration":[129,162],"(range":[130],"0.005-0.59":[131],"declined":[136,172],"from":[137,174],"0.14":[138],"+/-":[139,148],"0.04":[140],"micrograms/mL":[141,150,167],"injection":[145],"to":[146,177],"0.08":[147],"0.06":[149],"injection.":[154],"proportion":[156],"patients":[158],"above":[165],"0.018":[166,197],"significantly":[173],"(P":[180],"=":[181],".03).":[182],"Overall,":[183],"nine":[184],"25":[186],"(36%)":[188],"had":[189],"that":[193,237],"less":[195],"than":[196],"micrograms/mL.":[198],"CONCLUSION:":[199],"A":[200],"wide":[201],"range":[202],"observed":[207],"umbilical":[218],"AF":[222],"within":[223],"week":[225],"G":[233],"IM.":[234],"speculate":[236],"altered":[238],"pharmacokinetics":[239],"may":[240],"affect":[241],"efficacy":[243],"this":[245],"drug":[246],"prevention":[248],"congenital":[250],"syphilis":[251],"near-term":[254]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
