{"id":"https://openalex.org/W48291372","doi":"https://doi.org/10.4049/jimmunol.186.supp.52.27","title":"The inhibition of T cell proliferation in a mixed lymphocyte reaction by Itolizumab (T1h) is associated with reduction in pro inflammatory cytokines and CD6 internalization. (52.27)","display_name":"The inhibition of T cell proliferation in a mixed lymphocyte reaction by Itolizumab (T1h) is associated with reduction in pro inflammatory cytokines and CD6 internalization. (52.27)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W48291372","doi":"https://doi.org/10.4049/jimmunol.186.supp.52.27","mag":"48291372"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.52.27","doi":"https://doi.org/10.4049/jimmunol.186.supp.52.27","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.52.27","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077841973","display_name":"Pradip Nair","orcid":"https://orcid.org/0000-0002-5272-0478","observed_orcids":["https://orcid.org/0000-0002-5272-0478"]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pradip Nair","raw_affiliation_strings":["Research and Development, Biocon Limited , Bangalore ,","1Research and Development, Biocon Limited, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Biocon Limited , Bangalore ,","institution_ids":["https://openalex.org/I4210143327"]},{"raw_affiliation_string":"1Research and Development, Biocon Limited, Bangalore, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051496804","display_name":"Abhijit Ghorai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhijit Ghorai","raw_affiliation_strings":["Research and Development, Biocon Limited , Bangalore ,","1Research and Development, Biocon Limited, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Biocon Limited , Bangalore ,","institution_ids":["https://openalex.org/I4210143327"]},{"raw_affiliation_string":"1Research and Development, Biocon Limited, Bangalore, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020733429","display_name":"Laxmi Adhikary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Laxmi Adhikary","raw_affiliation_strings":["Research and Development, Biocon Limited , Bangalore ,","1Research and Development, Biocon Limited, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Biocon Limited , Bangalore ,","institution_ids":["https://openalex.org/I4210143327"]},{"raw_affiliation_string":"1Research and Development, Biocon Limited, Bangalore, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002813650","display_name":"Ramakrishnan Melarkode","orcid":"https://orcid.org/0000-0003-1977-3014","observed_orcids":["https://orcid.org/0000-0003-1977-3014"]},"institutions":[{"id":"https://openalex.org/I4210143327","display_name":"Biocon (India)","ror":"https://ror.org/047kynf18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210143327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramakrishnan Melarkode","raw_affiliation_strings":["Research and Development, Biocon Limited , Bangalore ,","1Research and Development, Biocon Limited, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Biocon Limited , Bangalore ,","institution_ids":["https://openalex.org/I4210143327"]},{"raw_affiliation_string":"1Research and Development, Biocon Limited, Bangalore, India","institution_ids":["https://openalex.org/I4210143327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030297062","display_name":"Enrique Montero","orcid":"https://orcid.org/0000-0002-7127-6675","observed_orcids":["https://orcid.org/0000-0002-7127-6675"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Enrique Montero","raw_affiliation_strings":["Center of Molecular Immunology , Havana ,","2Center of Molecular Immunology, Havana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Immunology , Havana ,","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"2Center of Molecular Immunology, Havana, Cuba","institution_ids":["https://openalex.org/I2355400"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"52.27","last_page":"52.27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.21770000457763672,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itolizumab","display_name":"itolizumab","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cd6","display_name":"CD6","score":0.8199999928474426},{"id":"https://openalex.org/keywords/activated-leukocyte-cell-adhesion-molecule","display_name":"ALCAM","score":0.9819999933242798},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.828000009059906},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fc-glycosylation","display_name":"Fc glycosylation","score":0.875},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6545672416687012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5525158643722534},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.482835590839386},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47722867131233215},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.46730825304985046},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4641968011856079},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.460909903049469},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.44241416454315186},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4326988756656647},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.43219563364982605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3483549952507019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.339904248714447},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3104704022407532},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24057382345199585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13168761134147644},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12326446175575256}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.52.27","doi":"https://doi.org/10.4049/jimmunol.186.supp.52.27","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.52.27","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319433827","https://openalex.org/W2731611291","https://openalex.org/W4313406001","https://openalex.org/W4320061587","https://openalex.org/W4313373244","https://openalex.org/W2147971828","https://openalex.org/W4404174278","https://openalex.org/W1489752262","https://openalex.org/W7203745548","https://openalex.org/W2076795211"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2],"shown":[3],"previously":[4],"that":[5,66,122,187],"the":[6,40,56,67,80,123,134,143,157,180,188,208,213],"CD6-ALCAM":[7,41],"interaction":[8],"in":[9,51,73,93,99,106,130,133,156,169,198],"vitro":[10],"induced":[11,42,197],"a":[12,30,74,147,205],"synergistic":[13],"co-stimulation":[14],"of":[15,29,44,136,153,212],"normal":[16,181],"human":[17],"peripheral":[18],"blood":[19],"mononuclear":[20],"cells":[21,83,132,155],"(PBMCs),":[22],"defined":[23],"by":[24],"Bliss":[25],"analysis.":[26],"The":[27,87,161],"use":[28],"CD6":[31,125,176],"membrane-distal":[32],"domain":[33],"(SRCR1)-specific":[34],"non-depleting":[35],"monoclonal":[36,189],"antibody":[37,68,149,163,190,214],"Itolizumab,":[38],"inhibited":[39],"proliferation":[43,72,196],"PBMCs.":[45],"This":[46],"is":[47,89,114,139,204],"associated":[48,90],"with":[49,91],"reduction":[50,92,105],"pro":[52],"inflammatory":[53],"cytokines":[54],"at":[55],"protein":[57],"and":[58,95,111,138,202],"mRNA":[59],"level.":[60],"In":[61],"this":[62,217],"study,":[63],"we":[64,120],"show":[65,121,166],"inhibits":[69],"T":[70,101,131,154,194],"cell":[71,174,195],"typical":[75],"mixed":[76,158,199],"lymphocyte":[77,159,200],"reaction":[78],"wherein":[79],"matured":[81],"dendritic":[82],"over":[84],"express":[85],"ALCAM.":[86],"inhibition":[88,152],"CD4":[94],"CD25":[96],"surface":[97],"expression":[98],"these":[100],"cells.":[102],"A":[103],"marked":[104],"interferon-\u03b3,":[107],"tumour":[108],"necrosis":[109],"factor-\u03b1":[110],"IL-17":[112],"production":[113],"also":[115,192],"observed.":[116],"Using":[117],"confocal":[118],"microscopy":[119],"receptor":[124],"internalization":[126],"occurs":[127],"within":[128],"minutes":[129],"presence":[135],"Itolizumab":[137,191],"not":[140,165],"localized":[141],"to":[142,171,179,215],"immunological":[144],"synapse.":[145],"Intriguingly,":[146],"deglycosylated":[148,162],"showed":[150],"reduced":[151],"reaction.":[160],"did":[164],"any":[167],"difference":[168],"binding":[170],"HuT":[172],"78":[173],"expressing":[175],"as":[177],"compared":[178],"antibody.":[182],"These":[183],"results":[184],"would":[185],"suggest":[186],"prevents":[193],"reactions":[201],"there":[203],"role":[206],"for":[207],"Fc":[209],"region":[210],"glycosylation":[211],"elucidate":[216],"function.":[218]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}