{"id":"https://openalex.org/W48044690","doi":"https://doi.org/10.3390/medicina48100078","title":"Comparison of the Effects of Glibenclamide on Metabolic Parameters, GLUT1 Expression, and Liver Injury in Rats With Severe and Mild Streptozotocin-Induced Diabetes Mellitus","display_name":"Comparison of the Effects of Glibenclamide on Metabolic Parameters, GLUT1 Expression, and Liver Injury in Rats With Severe and Mild Streptozotocin-Induced Diabetes Mellitus","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W48044690","doi":"https://doi.org/10.3390/medicina48100078","mag":"48044690","pmid":"https://pubmed.ncbi.nlm.nih.gov/23324250"},"language":"en","primary_location":{"id":"doi:10.3390/medicina48100078","doi":"https://doi.org/10.3390/medicina48100078","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina48100078","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/medicina48100078","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038567891","display_name":"Je\u013cizaveta Sokolovska","orcid":"https://orcid.org/0000-0003-0448-8229","observed_orcids":["https://orcid.org/0000-0003-0448-8229"]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]},{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":true,"raw_author_name":"Jelizaveta Sokolovska","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","institution_ids":["https://openalex.org/I91123046"]},{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055069947","display_name":"Sergejs Isajevs","orcid":"https://orcid.org/0000-0001-7159-0464","observed_orcids":["https://orcid.org/0000-0001-7159-0464"]},"institutions":[{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Sergejs Isajevs","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of Latvia","institution_ids":["https://openalex.org/I91123046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025953643","display_name":"Olga Sugoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Olga Sugoka","raw_affiliation_strings":["Group of Genomics and Bioinformatics, Institute of Biology, University of Latvia, Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Genomics and Bioinformatics, Institute of Biology, University of Latvia, Latvia","institution_ids":["https://openalex.org/I91123046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066423384","display_name":"Jelena Sharipova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Jelena Sharipova","raw_affiliation_strings":["Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062529090","display_name":"Natalia Paramonova","orcid":"https://orcid.org/0000-0001-6375-3331","observed_orcids":["https://orcid.org/0000-0001-6375-3331"]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Natalia Paramonova","raw_affiliation_strings":["Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090206420","display_name":"Darja Isajeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Darja Isajeva","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of Latvia","institution_ids":["https://openalex.org/I91123046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067826256","display_name":"Evita Rostoka","orcid":"https://orcid.org/0000-0001-5784-7729","observed_orcids":["https://orcid.org/0000-0001-5784-7729"]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]},{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Evita Rostoka","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","institution_ids":["https://openalex.org/I91123046"]},{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018015910","display_name":"Tatjana Sjakste","orcid":"https://orcid.org/0000-0003-2060-3944","observed_orcids":["https://orcid.org/0000-0003-2060-3944"]},"institutions":[{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Tatjana Sjakste","raw_affiliation_strings":["Group of Genomics and Bioinformatics, Institute of Biology, University of Latvia, Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group of Genomics and Bioinformatics, Institute of Biology, University of Latvia, Latvia","institution_ids":["https://openalex.org/I91123046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042378987","display_name":"Ivars Kalvinsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]}],"countries":["LV"],"is_corresponding":true,"raw_author_name":"Ivars Kalvinsh","raw_affiliation_strings":["Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024444007","display_name":"Nikolajs Sjakste","orcid":"https://orcid.org/0000-0002-4714-8016","observed_orcids":["https://orcid.org/0000-0002-4714-8016"]},"institutions":[{"id":"https://openalex.org/I4210102248","display_name":"Latvijas Organisk\u0101s Sint\u0113zes Instit\u016bts","ror":"https://ror.org/01a92vw29","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4210102248","https://openalex.org/I70055295"]},{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Nikolajs Sjakste","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","Latvian Institute of Organic Synthesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, University of Latvia","institution_ids":["https://openalex.org/I91123046"]},{"raw_affiliation_string":"Latvian Institute of Organic Synthesis","institution_ids":["https://openalex.org/I4210102248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038567891","https://openalex.org/A5042378987"],"corresponding_institution_ids":["https://openalex.org/I4210102248","https://openalex.org/I91123046"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":1.4416,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.8063509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"10","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.14069999754428864,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":1.0},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.8019999861717224},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6859999895095825},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.6869999766349792},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.9079999923706055},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.656000018119812},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.5299999713897705},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.3580000102519989},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.9268054962158203},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8063427805900574},{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.7403571605682373},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6961368322372437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6190627217292786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.594984769821167},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5011234283447266},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47342970967292786},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.17587214708328247},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1438291072845459}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013453","descriptor_name":"Sulfonylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3390/medicina48100078","doi":"https://doi.org/10.3390/medicina48100078","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina48100078","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmid:23324250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23324250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.3390/medicina48100078","doi":"https://doi.org/10.3390/medicina48100078","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina48100078","pdf_url":null,"source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323297","display_name":"Latvijas Universitate","ror":"https://ror.org/05g3mes96"},{"id":"https://openalex.org/F4320323603","display_name":"Universidad de la Rep\u00fablica Uruguay","ror":"https://ror.org/030bbe882"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1482626390","https://openalex.org/W1499500424","https://openalex.org/W1898694844","https://openalex.org/W1976778501","https://openalex.org/W1981900811","https://openalex.org/W2006593347","https://openalex.org/W2011633909","https://openalex.org/W2020459802","https://openalex.org/W2025501687","https://openalex.org/W2032037180","https://openalex.org/W2036191719","https://openalex.org/W2046380971","https://openalex.org/W2050315451","https://openalex.org/W2064103928","https://openalex.org/W2070431647","https://openalex.org/W2082751522","https://openalex.org/W2085608095","https://openalex.org/W2097757455","https://openalex.org/W2106481293","https://openalex.org/W2109652815","https://openalex.org/W2146937788","https://openalex.org/W2171185920","https://openalex.org/W2409529143","https://openalex.org/W2417960369"],"related_works":["https://openalex.org/W2094943143","https://openalex.org/W36757664","https://openalex.org/W2146937788","https://openalex.org/W2036678616","https://openalex.org/W2146587152","https://openalex.org/W4280488141","https://openalex.org/W2094198545","https://openalex.org/W2779181037","https://openalex.org/W1824738264","https://openalex.org/W1998970068"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,47],"OBJECTIVE:":[2],"Glucose":[3],"transport":[4],"via":[5],"GLUT1":[6,22,92,144,172,205,234],"protein":[7,26,96,147,180,209],"could":[8],"be":[9,219,239,249],"one":[10],"of":[11,14,18,35,82,108,130,164,191,200,214,229],"additional":[12],"mechanisms":[13],"the":[15,21,25,33,95,99,118,124,150,153,162,171,179,185,189,195,198,204,208,242,262],"antidiabetic":[16],"action":[17],"sulfonylureas.":[19],"Here,":[20],"gene":[23,145,173,206,230],"and":[24,37,42,50,60,94,102,111,122,132,146,152,197,207,224,226,244,247,255],"expression":[27,97,148,174,210,235],"was":[28,54,84,104,156,175,211,236],"studied":[29,105],"in":[30,32,98,127,142,149,170,253],"rats":[31],"course":[34],"severe":[36,131,267],"mild":[38,51,133],"streptozotocin-induced":[39],"diabetes":[40,52,134,137],"mellitus":[41,53,138],"under":[43],"glibenclamide":[44,70,83,115,186,252],"treatment.":[45,187],"MATERIAL":[46],"METHODS:":[48],"Severe":[49,136],"induced":[55],"using":[56],"different":[57],"streptozotocin":[58],"doses":[59],"standard":[61],"or":[62],"high":[63],"fat":[64],"chow.":[65],"Rats":[66],"were":[67],"treated":[68],"with":[69],"(2":[71],"mg/kg":[72],"daily,":[73],"per":[74],"os":[75],"for":[76],"6":[77],"weeks).":[78],"The":[79,91,114,233],"therapeutic":[80],"effect":[81],"monitored":[85],"by":[86,106,159,184,221,241,251,266],"measuring":[87],"several":[88],"metabolic":[89],"parameters.":[90],"mRNA":[93],"kidneys,":[100],"heart,":[101,154],"liver":[103,190,199,263],"means":[107],"real-time":[109],"RT-PCR":[110],"immunohistochemistry.":[112],"RESULTS:":[113],"treatment":[116],"decreased":[117],"blood":[119],"glucose":[120,243],"concentration":[121],"increased":[123],"insulin":[125,245],"level":[126,181],"both":[128,143],"models":[129],"mellitus.":[135],"provoked":[139],"an":[140,168],"increase":[141,169],"kidneys":[151,163],"which":[155,217],"nearly":[157],"normalized":[158],"glibenclamide.":[160],"In":[161,188],"mildly":[165,201,256],"diabetic":[166,193,202,257],"rats,":[167,194,203],"neither":[176],"confirmed":[177],"on":[178],"nor":[182],"influenced":[183],"severely":[192,254],"heart":[196],"changed":[212],"independently":[213],"each":[215],"other,":[216],"might":[218],"explained":[220],"abortive":[222],"transcription,":[223],"pre-":[225],"posttranslational":[227],"modifications":[228],"expression.":[231],"CONCLUSIONS:":[232],"found":[237],"to":[238],"affected":[240],"levels":[246],"can":[248,260],"modulated":[250],"rats.":[258],"Glibenclamide":[259],"prevent":[261],"damage":[264],"caused":[265],"hyperglycemia.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}