{"id":"https://openalex.org/W48013213","doi":null,"title":"Update in pre-eclampsia.","display_name":"Update in pre-eclampsia.","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W48013213","mag":"48013213","pmid":"https://pubmed.ncbi.nlm.nih.gov/21213502"},"language":"en","primary_location":{"id":"pmid:21213502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21213502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054585340","display_name":"Pharuhas Chanprapaph","orcid":"https://orcid.org/0000-0001-8854-8326","observed_orcids":["https://orcid.org/0000-0001-8854-8326"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Pharuhas Chanprapaph","raw_affiliation_strings":["Maternal Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternal Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand","institution_ids":["https://openalex.org/I48076826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054585340"],"corresponding_institution_ids":["https://openalex.org/I48076826"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00736405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"87 Suppl 3","issue":null,"first_page":"S104","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gestational-hypertension","display_name":"gestational hypertension","score":0.9639999866485596},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.925000011920929},{"id":"https://openalex.org/keywords/maternal-mortality","display_name":"maternal mortality","score":0.9259999990463257},{"id":"https://openalex.org/keywords/perinatal-mortality","display_name":"perinatal mortality","score":0.8029999732971191},{"id":"https://openalex.org/keywords/placental-hypoperfusion","display_name":"placental hypoperfusion","score":0.8899999856948853},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oligohydramnios","display_name":"oligohydramnios","score":0.8809999823570251},{"id":"https://openalex.org/keywords/expectant-management","display_name":"expectant management","score":0.8029999732971191},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.718999981880188},{"id":"https://openalex.org/keywords/seizure-prophylaxis","display_name":"seizure prevention","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fetal-well-being-assessment","display_name":"fetal well-being assessment","score":0.6729999780654907},{"id":"https://openalex.org/keywords/preeclampsia-screening","display_name":"preeclampsia screening","score":0.8970000147819519},{"id":"https://openalex.org/keywords/preeclampsia-prevention","display_name":"preeclampsia prevention","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.5590000152587891},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9980000257492065},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/low-dose-aspirin","display_name":"low-dose aspirin","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9601227045059204},{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.7717792987823486},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6190410852432251},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5489230751991272},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5240238308906555},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5032476782798767},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48116812109947205},{"id":"https://openalex.org/C2908892503","wikidata":"https://www.wikidata.org/wiki/Q1339474","display_name":"Maternal death","level":3,"score":0.4684363007545471},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4622717797756195},{"id":"https://openalex.org/C2778506911","wikidata":"https://www.wikidata.org/wiki/Q2849606","display_name":"Vasospasm","level":3,"score":0.44975700974464417},{"id":"https://openalex.org/C2776886772","wikidata":"https://www.wikidata.org/wiki/Q2099138","display_name":"Placental insufficiency","level":5,"score":0.4398495554924011},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3273114562034607},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28159427642822266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21337926387786865},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.13958489894866943},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.12779417634010315},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.10632357001304626},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1025383472442627},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21213502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21213502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},{"id":"mag:48013213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21213502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1510145219","https://openalex.org/W1577579821","https://openalex.org/W1966450184","https://openalex.org/W1967657067","https://openalex.org/W1968291490","https://openalex.org/W1968486632","https://openalex.org/W1968785526","https://openalex.org/W1970753042","https://openalex.org/W1972162642","https://openalex.org/W1979119639","https://openalex.org/W1979516217","https://openalex.org/W1980421688","https://openalex.org/W1981398964","https://openalex.org/W1981611554","https://openalex.org/W1983555250","https://openalex.org/W1985047171","https://openalex.org/W1986143232","https://openalex.org/W1994366950","https://openalex.org/W1998936516","https://openalex.org/W2001699197","https://openalex.org/W2003397776","https://openalex.org/W2004348770","https://openalex.org/W2010052445","https://openalex.org/W2011916169","https://openalex.org/W2014124077","https://openalex.org/W2021280017","https://openalex.org/W2023253812","https://openalex.org/W2023822513","https://openalex.org/W2025201758","https://openalex.org/W2025633088","https://openalex.org/W2028240282","https://openalex.org/W2031722452","https://openalex.org/W2032424279","https://openalex.org/W2037739988","https://openalex.org/W2044805923","https://openalex.org/W2049009844","https://openalex.org/W2052886560","https://openalex.org/W2055733550","https://openalex.org/W2061472006","https://openalex.org/W2071098846","https://openalex.org/W2072605137","https://openalex.org/W2074534257","https://openalex.org/W2078709831","https://openalex.org/W2082725991","https://openalex.org/W2083789788","https://openalex.org/W2084009664","https://openalex.org/W2084688828","https://openalex.org/W2094309256","https://openalex.org/W2096003082","https://openalex.org/W2104732966","https://openalex.org/W2108082438","https://openalex.org/W2120572766","https://openalex.org/W2133479239","https://openalex.org/W2142738495","https://openalex.org/W2142754757","https://openalex.org/W2143438629","https://openalex.org/W2153135266","https://openalex.org/W2154134573","https://openalex.org/W2159882259","https://openalex.org/W2159932969","https://openalex.org/W2162156431","https://openalex.org/W2162898500","https://openalex.org/W2297421172","https://openalex.org/W2315409533","https://openalex.org/W2319380181","https://openalex.org/W2320907419","https://openalex.org/W2323304773","https://openalex.org/W2332128238","https://openalex.org/W2356216364","https://openalex.org/W2982827845","https://openalex.org/W3026022109","https://openalex.org/W3160565403"],"related_works":["https://openalex.org/W4399656464","https://openalex.org/W2263282428","https://openalex.org/W2170500222","https://openalex.org/W4230432197","https://openalex.org/W2395357730","https://openalex.org/W2022992459","https://openalex.org/W2070472478","https://openalex.org/W2115545058","https://openalex.org/W4256129811","https://openalex.org/W2949742435"],"abstract_inverted_index":{"Pre-eclampsia,":[0],"formerly":[1],"called":[2],"pregnancy-induced":[3],"hypertension,":[4],"refers":[5],"to":[6,90,108,132,177,205,218],"the":[7,61,71,78,122,141,160,207,270],"new":[8],"onset":[9],"of":[10,45,64,73,77,111,124,144,180,225],"hypertension":[11],"(SBP":[12],">":[13,20],"or":[14,18,21,28,38,259],"=":[15,22,29],"140":[16],"mmHg":[17],"DBP":[19],"90":[23],"mmHg)":[24],"and":[25,59,81,86,92,103,117,148,157,184,198,221,254],"proteinuria":[26],"(>":[27],"0.3":[30],"g":[31],"protein":[32],"in":[33,47,83,251,267,269],"a":[34,48,54],"24-hour":[35],"urine":[36],"specimen":[37],"1+":[39],"on":[40],"dipstick)":[41],"after":[42],"20":[43],"weeks":[44,179],"gestation":[46],"previously":[49],"normotensive":[50],"women.":[51],"It":[52],"is":[53,97,154],"life-threatening,":[55],"multi-organ":[56],"involvement":[57],"disease":[58],"remains":[60,140],"leading":[62],"cause":[63],"maternal":[65],"death.":[66],"Its":[67],"clinical":[68],"manifestations":[69],"are":[70,121,202,240],"result":[72],"generalized":[74],"vasospasm,":[75],"activation":[76],"coagulation":[79],"system,":[80],"changes":[82],"several":[84],"humoral":[85],"autoregulatory":[87],"systems":[88],"related":[89],"volume":[91],"blood":[93,193],"pressure":[94,194],"control.":[95],"Pre-eclampsia":[96,128],"responsible":[98],"for":[99,146,159,170,262],"high":[100],"perinatal":[101],"mortality":[102],"morbidity":[104],"rates,":[105],"primarily":[106],"due":[107],"early":[109],"termination":[110],"pregnancy.":[112],"Fetus":[113],"growth":[114],"restriction,":[115],"oligohyrdramnios":[116],"non-reassuring":[118],"fetal":[119,134,199],"status":[120],"consequences":[123],"chronic":[125],"placental":[126],"hypoperfusion.":[127],"does":[129],"not":[130,155],"appear":[131],"accelerate":[133],"maturation,":[135],"as":[136,192,265],"once":[137],"believed.":[138],"Delivery":[139],"definitive":[142],"treatment":[143],"choice":[145],"pre-eclampsia":[147,226],"should":[149],"be":[150,168,219],"timely.":[151],"Cesarean":[152],"section":[153],"necessary":[156],"reserved":[158],"obstetrical":[161],"indications":[162],"only.":[163],"The":[164,188,223],"expectant":[165],"management":[166,190],"may":[167],"considered":[169],"women":[171,268],"remote":[172],"from":[173],"term":[174],"(<":[175],"32":[176],"34":[178],"gestation)":[181],"with":[182,227],"stable":[183],"uncomplicated":[185],"severe":[186],"disease.":[187],"supportive":[189],"such":[191],"control,":[195],"seizure":[196],"prevention,":[197],"well-being":[200],"assessment":[201],"also":[203],"important":[204],"ensure":[206],"satisfactory":[208],"outcome.":[209],"To":[210],"date,":[211],"no":[212,249,260],"screening":[213],"test":[214],"has":[215,233,247],"been":[216],"proved":[217],"reliable":[220],"cost-effective.":[222],"prevention":[224,266],"antioxidant":[228],"therapy":[229],"(vitamin":[230],"C,":[231],"E)":[232],"shown":[234,248],"promise,":[235],"but":[236],"large,":[237],"randomized":[238],"trials":[239],"needed.":[241],"Although":[242],"controversy":[243],"exists,":[244],"calcium":[245],"supplementation":[246],"benefit":[250,261],"large":[252],"trials,":[253],"most":[255],"evidence":[256],"suggests":[257],"little":[258],"low-dose":[263],"aspirin":[264],"low-risk":[271],"category.":[272]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}