{"id":"https://openalex.org/W47844155","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","title":"Increased TGFb signaling in type I diabetic mice is associated with parasympathetic dysfunction of the heart","display_name":"Increased TGFb signaling in type I diabetic mice is associated with parasympathetic dysfunction of the heart","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W47844155","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","mag":"47844155"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.524.14","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047040540","display_name":"Serban Paul Georgescu","orcid":"https://orcid.org/0000-0003-0444-0110","observed_orcids":["https://orcid.org/0000-0003-0444-0110"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serban Georgescu","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017766988","display_name":"Jack Naggar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack C Naggar","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088805332","display_name":"Charles M. Welzig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Welzig","raw_affiliation_strings":["Medical University of South Carolina Charleston SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina Charleston SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101815766","display_name":"Yali Zhang","orcid":"https://orcid.org/0000-0002-7998-3008","observed_orcids":["https://orcid.org/0000-0002-7998-3008"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yali Zhang","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066082765","display_name":"Gun-Hoo Park","orcid":"https://orcid.org/0000-0001-7860-3459","observed_orcids":["https://orcid.org/0000-0001-7860-3459"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ho\u2010Jin Park","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034869650","display_name":"Eric C. Wooten","orcid":"https://orcid.org/0000-0002-8403-8668","observed_orcids":["https://orcid.org/0000-0002-8403-8668"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C Wooten","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110152621","display_name":"Mark J. Aronovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J Aronovitz","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904713","display_name":"Richard H. Karas","orcid":"https://orcid.org/0000-0001-7799-091X","observed_orcids":["https://orcid.org/0000-0001-7799-091X"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H Karas","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041781226","display_name":"Gordon S. Huggins","orcid":"https://orcid.org/0000-0002-8035-0312","observed_orcids":["https://orcid.org/0000-0002-8035-0312"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon S Huggins","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090446116","display_name":"Jonas Galper","orcid":"https://orcid.org/0000-0001-5737-9734","observed_orcids":["https://orcid.org/0000-0001-5737-9734"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas B Galper","raw_affiliation_strings":["Molecular Cardiology Research Institute Tufts Medical Center Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00484751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.18330000340938568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.09730000048875809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-autonomic-neuropathy","display_name":"diabetic autonomic neuropathy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/parasympathetic-dysfunction","display_name":"parasympathetic dysfunction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cardiac-autonomic-function","display_name":"cardiac autonomic function","score":0.5920000076293945},{"id":"https://openalex.org/keywords/akita-mice","display_name":"Akita mice","score":0.8320000171661377},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7988218665122986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7480527758598328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7195322513580322},{"id":"https://openalex.org/C158328960","wikidata":"https://www.wikidata.org/wiki/Q1088369","display_name":"Chronotropic","level":4,"score":0.7176389694213867},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6059513688087463},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.5257580876350403},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5072145462036133},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.45168524980545044},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.44890186190605164},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4144750237464905},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3335581421852112},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.32692059874534607},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3026496469974518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17308157682418823},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.05137696862220764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.524.14","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.524.14","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3177454784","https://openalex.org/W2423505962","https://openalex.org/W3004783418","https://openalex.org/W2980836120","https://openalex.org/W3168758252","https://openalex.org/W420892873","https://openalex.org/W2063977326","https://openalex.org/W2138266173","https://openalex.org/W2156971116","https://openalex.org/W2279931167"],"abstract_inverted_index":{"Diabetic":[0],"Autonomic":[1],"Neuropathy":[2],"(DAN),":[3],"a":[4,93,108,113],"severe":[5,14],"complication":[6],"of":[7,38,45,76,118,134,140,191],"diabetes,":[8],"is":[9,186],"associated":[10,187],"with":[11,158,188],"parasympathetic":[12,48,81,167,189],"dysfunction,":[13],"arrhythmias":[15],"and":[16,34,42,64,112,136,151,194],"sudden":[17],"death.":[18],"We":[19],"had":[20],"shown":[21],"in":[22,56,62,65,131,154,169,173,178,200,204],"cardiac":[23,47,170],"myocytes":[24],"that":[25,162,177,195],"TGFb":[26,51,88,141,163,184,196],"attenuates":[27,165],"the":[28,36,46,57,73,77,125,166,192,201,205],"negative":[29],"chronotropic":[30],"response":[31,75,168],"to":[32,80,86,100,116,123],"Carbamylcholine":[33],"decreases":[35],"expression":[37,133],"M2":[39],"muscarinic":[40],"receptor":[41],"Gai2":[43],"(components":[44],"response).":[49],"Increased":[50],"signaling":[52,185],"has":[53],"been":[54],"implicated":[55],"end":[58],"organ":[59],"damage":[60],"mechanisms":[61,203],"patients":[63],"type":[66,103,179],"I":[67,104,180],"diabetic":[68,78,105,126,181,206],"animal":[69,95],"models.":[70],"Our":[71],"hypothesis:":[72],"decreased":[74,109],"heart":[79,120,127],"stimulation":[82,164],"might":[83],"be":[84,198],"due":[85],"increased":[87,149],"signaling.":[89],"Here":[90],"we":[91],"present":[92],"new":[94],"model":[96],"for":[97],"DAN.":[98],"Compared":[99,122],"WT,":[101,124],"Akita":[102,155],"mice":[106,182],"showed":[107,128,148],"Carbamylcholine\u2010induced":[110],"bradycardia":[111],"faster":[114],"recovery":[115],"80%":[117],"initial":[119],"rate.":[121],"significant":[129],"increases":[130],"mRNA":[132],"TGFbRII":[135,152],"PAI\u20101":[137],"(a":[138],"target":[139],"signaling).":[142],"Western":[143],"blots":[144],"using":[145],"hearts":[146],"lysates":[147],"phospho\u2010Smad2/3":[150],"levels":[153],"mice.":[156],"Together":[157],"our":[159],"previous":[160],"data":[161],"myocytes,":[171],"these":[172],"vivo":[174],"results":[175],"suggest":[176],"elevated":[183],"dysfunction":[190],"heart,":[193],"may":[197],"involved":[199],"arrhythmia":[202],"heart.":[207]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}