{"id":"https://openalex.org/W47811787","doi":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","title":"Primary Neuroendocrine Carcinoma of the Vagina With Merkel Cell Carcinoma Phenotype","display_name":"Primary Neuroendocrine Carcinoma of the Vagina With Merkel Cell Carcinoma Phenotype","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W47811787","doi":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","mag":"47811787","pmid":"https://pubmed.ncbi.nlm.nih.gov/16538063"},"language":"en","primary_location":{"id":"doi:10.1097/01.pas.0000194737.95421.9d","doi":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108786260","display_name":"Neil M. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil M. Coleman","raw_affiliation_strings":["Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. ncoleman@bcm.tmc.edu","Departments of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. ncoleman@bcm.tmc.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049907635","display_name":"Megan J. Smith\u2010Zagone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Megan J. Smith-Zagone","raw_affiliation_strings":["Departments of Pathology","Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]},{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039245628","display_name":"Janos Laszlo Tanyi","orcid":"https://orcid.org/0000-0002-5657-3698","observed_orcids":["https://orcid.org/0000-0002-5657-3698"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janos Tanyi","raw_affiliation_strings":["Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057245448","display_name":"Matthew Linley Anderson","orcid":"https://orcid.org/0000-0002-2081-4672","observed_orcids":["https://orcid.org/0000-0002-2081-4672"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew L. Anderson","raw_affiliation_strings":["Departments of Gynecologic Oncology","Departments of Pathology","Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gynecologic Oncology","institution_ids":[]},{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]},{"raw_affiliation_string":"Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106132854","display_name":"Robert L. Coleman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Coleman","raw_affiliation_strings":["Departments of Gynecologic Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gynecologic Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007852560","display_name":"Senait W. Dyson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Senait W. Dyson","raw_affiliation_strings":["Pathology and Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064075341","display_name":"Jon A. Reed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jon A. Reed","raw_affiliation_strings":["Departments of Pathology","Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology","institution_ids":[]},{"raw_affiliation_string":"Dermatology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049907635","https://openalex.org/A5057245448","https://openalex.org/A5064075341","https://openalex.org/A5108786260"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":1.9526,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.8529765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"405","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merkel-cell-carcinoma","display_name":"Merkel cell carcinoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vaginal-neoplasms","display_name":"vaginal neoplasms","score":0.699999988079071},{"id":"https://openalex.org/keywords/cytokeratin-20","display_name":"CK20","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7440000176429749},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.656000018119812},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778342957","wikidata":"https://www.wikidata.org/wiki/Q1711744","display_name":"Merkel cell carcinoma","level":3,"score":0.8931187987327576},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.7787244319915771},{"id":"https://openalex.org/C2780291066","wikidata":"https://www.wikidata.org/wiki/Q1570264","display_name":"Merkel cell","level":4,"score":0.7455509305000305},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.7013360261917114},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6640758514404297},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.6162369251251221},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5550442934036255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.51720130443573},{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.5110737085342407},{"id":"https://openalex.org/C2776187983","wikidata":"https://www.wikidata.org/wiki/Q1921796","display_name":"Merkel cell polyomavirus","level":4,"score":0.41428685188293457},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3134665787220001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2510174810886383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23575109243392944},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014625","descriptor_name":"Vaginal Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014625","descriptor_name":"Vaginal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014625","descriptor_name":"Vaginal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pas.0000194737.95421.9d","doi":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pas.0000194737.95421.9d","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:16538063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16538063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161025703","https://openalex.org/W1971805543","https://openalex.org/W2095435465","https://openalex.org/W1981632384","https://openalex.org/W1978752817","https://openalex.org/W1995843467","https://openalex.org/W4221039175","https://openalex.org/W2052585687","https://openalex.org/W1984754325","https://openalex.org/W102575622"],"abstract_inverted_index":{"We":[0],"describe":[1],"a":[2,15,25,75,103,152,162,170,206],"case":[3],"of":[4,14,21,50,60,105,111,119,127,147,161,166,182,189,194,201,211],"primary":[5,47,163,179,197],"neuroendocrine":[6,19,48,164,180],"carcinoma":[7,20,49,165,181,188,200,209],"arising":[8],"from":[9,46,185],"the":[10,22,35,51,158,167,183,190,202],"anterior":[11],"vaginal":[12],"wall":[13],"67-year-old":[16],"woman.":[17],"Primary":[18],"vagina":[23,168,184,203],"is":[24,149,157],"rare":[26],"entity":[27],"with":[28,67,151,169],"only":[29],"25":[30],"previously":[31],"reported":[32],"cases":[33],"in":[34,196],"literature.":[36],"In":[37],"previous":[38],"reports,":[39],"these":[40],"tumors":[41],"have":[42,176],"not":[43,177],"been":[44],"distinguished":[45,178],"skin":[52],"(Merkel":[53],"cell":[54,154,172,187,199,208],"carcinoma).":[55],"The":[56,82,113],"tumor":[57,83,114],"was":[58,79,107],"composed":[59],"cells":[61,84,115],"that":[62,78],"showed":[63,116],"neuroendocrine-type":[64],"nuclear":[65,69],"features":[66],"hyperchromasia,":[68],"molding,":[70],"occasional":[71],"small":[72,198],"nucleoli,":[73],"and":[74,98,122,138],"chromatin":[76],"pattern":[77,146],"finely":[80],"granular.":[81],"were":[85,143],"positive":[86,109],"for":[87],"cytokeratin":[88,136],"20":[89],"(CK20),":[90],"neuron":[91],"specific":[92],"enolase,":[93],"pancytokeratin,":[94],"epithelial":[95],"membrane":[96],"antigen,":[97],"chromogranin":[99],"A":[100],"expression.":[101],"Ki-67,":[102],"marker":[104],"proliferation,":[106],"also":[108],"in>90%":[110],"cells.":[112],"intense":[117],"expression":[118,126,193],"Bcl-2":[120],"oncoprotein":[121],"mild":[123],"to":[124],"moderate":[125],"c-KIT.":[128],"Synaptophysin,":[129],"neurofilament,":[130],"CD45,":[131],"CD56,":[132],"CD10,":[133],"S-100,":[134],"HMB-45,":[135],"7,":[137],"thyroid":[139],"transcription":[140],"factor":[141],"1":[142],"negative.":[144],"This":[145,156],"staining":[148],"consistent":[150],"Merkel":[153,171,186,207],"carcinoma.":[155],"first":[159],"report":[160],"phenotype.":[173],"Previous":[174],"studies":[175],"skin.":[191],"Positive":[192],"CK20":[195],"might":[204],"represent":[205],"subtype":[210],"this":[212],"tumor.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}