{"id":"https://openalex.org/W47725433","doi":null,"title":"Estudo da susceptibilidade do VIH-2 \u00e0 inibi\u00e7\u00e3o por mol\u00e9culas inibidoras do co-recptor CCR5","display_name":"Estudo da susceptibilidade do VIH-2 \u00e0 inibi\u00e7\u00e3o por mol\u00e9culas inibidoras do co-recptor CCR5","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W47725433","mag":"47725433"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2384","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2384","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/2384","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101950178","display_name":"Maria Esp\u00edrito Santo","orcid":"https://orcid.org/0000-0001-8970-786X","observed_orcids":["https://orcid.org/0000-0001-8970-786X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Esp\u00edrito Santo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101950178"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.2295999974012375,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ccr5-antagonist","display_name":"CCR5 antagonist","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cxcr4-antagonist","display_name":"CXCR4 antagonist","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tak-779","display_name":"TAK-779","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mvc","display_name":"MVC","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sdf-1alpha","display_name":"SDF-1\u03b1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ghost-cells","display_name":"ghost cells","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cd4-positive-cells","display_name":"CD4-positive cells","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.39248988032341003},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.33376994729042053},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.14712926745414734}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2384","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2384","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:47725433","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ul.pt/bitstream/10451/2384/1/ulsd058276_tm_Maria_ESanto.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2384","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2384","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W138492706","https://openalex.org/W186756043","https://openalex.org/W284027589","https://openalex.org/W384644027","https://openalex.org/W1482346540","https://openalex.org/W1523087205","https://openalex.org/W1543146126","https://openalex.org/W1623426438","https://openalex.org/W1741697594","https://openalex.org/W1837528589","https://openalex.org/W1874436941","https://openalex.org/W1930184316","https://openalex.org/W1969343042","https://openalex.org/W1971620377","https://openalex.org/W1977282539","https://openalex.org/W1979149320","https://openalex.org/W1981621292","https://openalex.org/W1983747887","https://openalex.org/W1983846378","https://openalex.org/W1985061603","https://openalex.org/W1995355944","https://openalex.org/W1998102826","https://openalex.org/W1998992970","https://openalex.org/W1999048558","https://openalex.org/W2000660225","https://openalex.org/W2000825287","https://openalex.org/W2004714646","https://openalex.org/W2005780220","https://openalex.org/W2008791719","https://openalex.org/W2010521915","https://openalex.org/W2011389067","https://openalex.org/W2011621918","https://openalex.org/W2017044687","https://openalex.org/W2018849181","https://openalex.org/W2022261032","https://openalex.org/W2024011553","https://openalex.org/W2026444780","https://openalex.org/W2027738518","https://openalex.org/W2031379259","https://openalex.org/W2031389913","https://openalex.org/W2032020323","https://openalex.org/W2033309232","https://openalex.org/W2034576523","https://openalex.org/W2035365163","https://openalex.org/W2036288774","https://openalex.org/W2040186892","https://openalex.org/W2044004371","https://openalex.org/W2048336729","https://openalex.org/W2049394453","https://openalex.org/W2056360005","https://openalex.org/W2058252938","https://openalex.org/W2066591348","https://openalex.org/W2071422388","https://openalex.org/W2072922787","https://openalex.org/W2073863059","https://openalex.org/W2075521082","https://openalex.org/W2075811752","https://openalex.org/W2076991562","https://openalex.org/W2077563405","https://openalex.org/W2081688566","https://openalex.org/W2082042256","https://openalex.org/W2085464725","https://openalex.org/W2087364590","https://openalex.org/W2090681997","https://openalex.org/W2092012373","https://openalex.org/W2092866733","https://openalex.org/W2096211018","https://openalex.org/W2096965774","https://openalex.org/W2098781795","https://openalex.org/W2099749788","https://openalex.org/W2104318155","https://openalex.org/W2105877804","https://openalex.org/W2107506516","https://openalex.org/W2107973727","https://openalex.org/W2109097720","https://openalex.org/W2110182256","https://openalex.org/W2112394999","https://openalex.org/W2113282092","https://openalex.org/W2113332127","https://openalex.org/W2118812814","https://openalex.org/W2119829976","https://openalex.org/W2119951120","https://openalex.org/W2124193326","https://openalex.org/W2124935744","https://openalex.org/W2126515754","https://openalex.org/W2128618062","https://openalex.org/W2132195505","https://openalex.org/W2132622786","https://openalex.org/W2135532404","https://openalex.org/W2137267461","https://openalex.org/W2138901765","https://openalex.org/W2138950647","https://openalex.org/W2140478082","https://openalex.org/W2142766084","https://openalex.org/W2146084524","https://openalex.org/W2147169218","https://openalex.org/W2149428316","https://openalex.org/W2150001263","https://openalex.org/W2152026267","https://openalex.org/W2154963941","https://openalex.org/W2160767768","https://openalex.org/W2165895151","https://openalex.org/W2167788081","https://openalex.org/W2168261406","https://openalex.org/W2168357995","https://openalex.org/W2169623461","https://openalex.org/W2169974120","https://openalex.org/W2318289184","https://openalex.org/W2792390129","https://openalex.org/W2916973882","https://openalex.org/W4211132279"],"related_works":["https://openalex.org/W7029905144","https://openalex.org/W2234285416","https://openalex.org/W37495997","https://openalex.org/W6992733263","https://openalex.org/W7028856653","https://openalex.org/W7071152819","https://openalex.org/W2237896940","https://openalex.org/W2468883690","https://openalex.org/W1974247885","https://openalex.org/W7095225609"],"abstract_inverted_index":{"At\u00e9":[0],"\u00e0":[1,242],"data":[2],"deste":[3],"trabalho,":[4],"poucos":[5],"estudos":[6],"t\u00eam":[7,59],"sido":[8],"feitos":[9],"para":[10,206,211,226],"determinar":[11],"a":[12,23,44,48,68,100,112,166,227],"susceptibilidade":[13,69],"do":[14,63,70,74,82,138,200,209],"VIH-2":[15,91],"aos":[16,72],"antagonistas":[17,199],"dos":[18,53],"co-receptores":[19],"(CoR).":[20],"Estes":[21,193,231],"pertencem":[22],"um":[24,31,184],"grupo":[25],"de":[26,28,34,109],"inibidores":[27,55,73],"entrada":[29,49],"com":[30,190,223],"novo":[32],"mecanismo":[33],"ac\u00e7\u00e3o,":[35],"agindo":[36],"fora":[37],"da":[38,143],"c\u00e9lula,":[39],"ligam-se":[40],"ao":[41,51],"CoR,":[42],"impedindo":[43],"sua":[45],"utiliza\u00e7\u00e3o":[46],"durante":[47],"viral,":[50],"contr\u00e1rio":[52],"outros":[54],"j\u00e1":[56],"existentes,":[57],"que":[58,120,148,171,210,215],"por":[60,244],"alvo,":[61],"prote\u00ednas":[62],"HIV.":[64],"Neste":[65],"estudo,":[66],"determinou-se":[67],"HIV-2":[71,160,208],"CCR5":[75,128,201],"(TAK-779,":[76],"MVC,":[77],"PF-2221753":[78],"e":[79,81,85,93,98,125,152,214,237],"mAb2D7)":[80],"CXCR4":[83],"(SDF-1alpha":[84],"o":[86,122,126,149,153,162,172,181,191,207,212,216,224],"mAb12G5),":[87],"usando":[88],"seis":[89],"estirpes":[90,159,178],"isoladas":[92],"caracterizados":[94],"no":[95,240],"nosso":[96],"laborat\u00f3rio,":[97],"utilizando":[99],"estirpe":[101,167],"HIV-":[102],"1BaL":[103],"como":[104],"controlo.":[105],"Para":[106],"os":[107,198],"ensaios":[108],"inibi\u00e7\u00e3o,":[110],"utilizou-se":[111],"linha":[113],"celular":[114],"humana":[115],"obtida":[116],"dum":[117],"osteossarcoma":[118],"(GHOST)":[119],"expressa":[121],"receptor":[123],"CD4":[124],"co-receptor":[127],"ou":[129],"CXCR4.":[130],"A":[131],"replica\u00e7\u00e3o":[132],"viral":[133],"foi":[134],"monitorizada":[135],"pela":[136],"detec\u00e7\u00e3o":[137],"Ag":[139],"p24":[140],"nos":[141],"sobrenadantes":[142],"cultura.":[144],"Os":[145],"resultados":[146,194,232],"demonstraram":[147],"TAK-779,":[150],"MVC":[151],"PF-227153":[154],"inibiram":[155],"eficientemente":[156],"todas":[157],"as":[158],"enquanto":[161,180],"mAb2D7,":[163],"inibiu":[164,174],"apenas":[165],"HIV-2ALI.":[168],"Verificou-se":[169],"ainda":[170],"SDF-1alpha":[173,217],"tr\u00eas":[175],"das":[176,229],"quatro":[177],"estudadas,":[179],"mAb12G5":[182,225],"teve":[183],"efeito":[185],"inibit\u00f3rio":[186],"menor":[187],"quando":[188,221],"comparado":[189,222],"SDF-1alpha.":[192],"permitem-nos":[195],"concluir":[196],"que:":[197],"analisados":[202],"s\u00e3o":[203],"mais":[204,219],"eficientes":[205],"HIV-1BaL":[213],"\u00e9":[218],"eficaz":[220],"inibi\u00e7\u00e3o":[228],"estirpes.":[230],"sugerem":[233],"assim":[234],"novas":[235],"direc\u00e7\u00f5es":[236],"solu\u00e7\u00f5es":[238],"terap\u00eauticas":[239],"combate":[241],"infec\u00e7\u00e3o":[243],"HIV-2.":[245]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
